Results 51 to 60 of about 4,117,946 (252)

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Statistical reconstruction of transcription factor activity using Michaelis-Menten kinetics [PDF]

, 2007
Summary. The basic building block of a gene regulatory network consists of a gene encoding a transcription factor (TF) and the gene(s) it regulates. Considerable efforts have been directed recently at devising experiments and algorithms to determine TFs
Smith, C.P., Vinciotti, V., Smith, C P, Khanin, Raya, Mersinias, V., Wit, Ernst, Vinciotti, V, Mersinias, V, Smith, CP, Khanin, R, Wit, E, Khanin, R.   +11 more
core   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Functional and cell-specific regulation of the Brn-3b transcription factor by microRNAs [PDF]

, 2010
Post-transcriptional gene regulation is a very powerful and evolutionary conserved mechanism which allows cells to finely modulate gene expression by acting at the level of their mRNAs.
Calissano, M.
core  

DoGFinder: a software for the discovery and quantification of readthrough transcripts from RNA-seq

BMC Genomics, 2018
Background Recent studies have described a widespread induction of transcriptional readthrough as a consequence of various stress conditions in mammalian cells.
Yuval Wiesel, Niv Sabath, Reut Shalgi
doaj   +1 more source

Research Progress on Regulation of Antioxidant Transcription in Reactive Oxygen Species Metabolism of Postharvest Fruits and Vegetables during Low Temperature Storage

Shipin gongye ke-ji, 2023
Imbalance of active oxygen metabolism can lead to oxidative stress in postharvest fruits and vegetables, which could accelerate their quality deterioration, and ruin their commercial value.
Yang YANG, Qiqi CHEN, Lihong GUO, Quannü YANG, Fuwang WU   +4 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Transcriptional Regulation of the Beta-Synuclein 5′-Promoter Metal Response Element by Metal Transcription Factor-1 [PDF]

, 2011
The progression of many human neurodegenerative disorders is associated with an accumulation of alpha-synuclein. Alpha-synuclein belongs to the homologous synuclein family, which includes beta-synuclein.
Patrick C McHugh, David R. Brown, Josephine A. Wright, McHugh, Patrick C, Wright, Josephine A., Josephine A Wright, Wright Josephine A., Brown David R., David R Brown, McHugh Patrick C., Brown, David R., Patrick C. McHugh   +11 more
core   +1 more source

Dual Regulation of Tank Binding Kinase 1 by BRG1 in Hepatocytes Contributes to Reactive Oxygen Species Production

Frontiers in Cell and Developmental Biology, 2021
Excessive accumulation of reactive oxygen species (ROS) is considered a major culprit for the pathogenesis of non-alcoholic fatty liver disease (NAFLD).
Fangqiao Lv, Tinghui Shao, Yujia Xue, Xiulian Miao, Yan Guo, Yutong Wang, Yong Xu, Yong Xu   +7 more
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source