Results 81 to 90 of about 5,538,535 (384)

CRISPRa-mediated FOXP3 gene upregulation in mammalian cells

Cell & Bioscience, 2019
Background Forkhead box P3+ (FOXP3 +) regulatory T cells (Tregs) are a subset of lymphocytes, critical for the maintenance of immune homeostasis. Loss-of-function mutations of the FOXP3 gene in animal models and humans results in loss of differentiation ...
Vida Forstnerič, Irena Oven, Jernej Ogorevc, Duško Lainšček, Arne Praznik, Tina Lebar, Roman Jerala, Simon Horvat   +7 more
doaj   +1 more source

Histone deacetylase 3 contributes to the antiviral innate immunity of macrophages by interacting with FOXK1 to regulate STAT1/2 transcription

Cell Reports, 2022
Summary: It is well known that interferon (IFN)-α/-β activates the JAK/STAT signaling pathway and suppresses viral replication through the induction of IFN stimulated genes (ISGs).
Liping Yang, Shengchuan Chen, Qun Zhao, Chaohu Pan, Linan Peng, Yu Han, Lili Li, Jiayin Ruan, Jingyan Xia, Heng Yang, Feng Xu, Genhong Cheng   +11 more
doaj   +1 more source

Nejire/dCBP-mediated control of H3 acetylation and transcriptional regulation by testis-specific Plus3 domain proteins during Drosophila spermatogenesis [PDF]

, 2018
Spermatogenesis describes the development from germ line stem cells to highly specialized sperm. Drosophila melanogaster spermatogenesis is a good model system for chromatin remodelling processes as many of these processes are similar in mammals and in ...
Hundertmark, Tim
core   +1 more source

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

FEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu, Huseyn Babayev, Ismail Ogulur, Sena Ardicli, Yagiz Pat, Duygu Yazici, Bingjie Zhao, Lihong Chang, Xiaoqing Liu, Paolo D'Avino, Manru Li, Ceren Biçer, Fatma Hacer Kurtoğlu Babayev, Raja Dhir, Kari C. Nadeau, Marie‐Charlotte Brüggen, Mubeccel Akdis, Cezmi A. Akdis   +17 more
wiley   +1 more source

Role of Nocardia sp. bioactives in regulating the key molecular checkpoints in quorum-sensing pathways of P. aeruginosa: application towards improved fabrication of medical devices

Journal of Global Antimicrobial Resistance
AIM: Understanding the inhibitory role of bioactives from a novel Nocardia sp. against P. aeruginosa's Quorum-Sensing (QS) regulatory pathways and fabrication of effective foley catheters. BACKGROUND: P.
Saniya Zaidi, Nitin Srivastava, Moumita Ghosh, Deepti Jain, Sunil K. Khare, Paras N. Prasad   +5 more
doaj   +1 more source

On the mechanistic nature of epistasis in a canonical cis-regulatory element

eLife, 2017
Understanding the relation between genotype and phenotype remains a major challenge. The difficulty of predicting individual mutation effects, and particularly the interactions between them, has prevented the development of a comprehensive theory that ...
Mato Lagator, Tiago Paixão, Nicholas H Barton, Jonathan P Bollback, Călin C Guet   +4 more
doaj   +1 more source

A connection between stress and development in the multicelular prokaryote Streptomyces coelicolor [PDF]

, 2001
Morphological changes leading to aerial mycelium formation and sporulation in the mycelial bacterium Streptomyces coelicolor rely on establishing distinct patterns of gene expression in separate regions of the colony.
Bucca G., Champness W.C., Charles J. Thompson, Chater K.F., Elliot M., Elliot M.A., Gabriella H. Kelemen, Jennifer Tenor, Kelemen G.H., Kieser T., Laura Marri, Mandic-Mulec I., Mark J. Buttner, Merrick M.J., Patrick H. Viollier, Potuckova L., Price C.W., Ryding N.J., Schwedock J., Sun J., Vohradsky J., Volker U., Westpheling J., Willey J., Yang X.   +24 more
core   +1 more source

Targeting transcription regulation in cancer with a covalent CDK7 inhibitor

Nature, 2014
Tumour oncogenes include transcription factors that co-opt the general transcriptional machinery to sustain the oncogenic state, but direct pharmacological inhibition of transcription factors has so far proven difficult.
Nicholas Kwiatkowski, Tinghu Zhang, P. Rahl, B. Abraham, J. Reddy, S. Ficarro, A. Dastur, A. Amzallag, Sridhar Ramaswamy, B. Tesar, Christopher R. Jenkins, N. Hannett, Douglas W. McMillin, T. Sanda, Taebo Sim, N. Kim, T. Look, C. Mitsiades, A. Weng, Jennifer R. Brown, C. Benes, J. Marto, R. Young, N. Gray   +23 more
semanticscholar   +1 more source

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

Dual Regulation of Tank Binding Kinase 1 by BRG1 in Hepatocytes Contributes to Reactive Oxygen Species Production

Frontiers in Cell and Developmental Biology, 2021
Excessive accumulation of reactive oxygen species (ROS) is considered a major culprit for the pathogenesis of non-alcoholic fatty liver disease (NAFLD).
Fangqiao Lv, Tinghui Shao, Yujia Xue, Xiulian Miao, Yan Guo, Yutong Wang, Yong Xu, Yong Xu   +7 more
doaj   +1 more source