Results 1 to 10 of about 187,265 (157)

Regulation of Transcription Elongation and Termination [PDF]

Biomolecules, 2015
This article will review our current understanding of transcription elongation and termination in E. coli. We discuss why transcription elongation complexes pause at certain template sites and how auxiliary host and phage transcription factors affect ...
Robert S. Washburn, Max E. Gottesman
doaj   +6 more sources

Canonical transcription termination mechanisms explain a minority of operons in cyanobacteria [PDF]

mSystems
Cyanobacteria are abundant phototrophs and hold potential as a carbon-negative platform for bioengineering applications. However, these efforts have been hampered by limited mechanistic understanding of their gene expression, including transcription ...
Jennifer A. Cascino, K. Julia Dierksheide, Rishi K. Vishwakarma, Yulia Yuzenkova, Paul Babitzke, Katsuhiko S. Murakami, Gene-Wei Li   +6 more
doaj   +3 more sources

The yeast checkpoint kinase Mec1p functions in transcription termination by facilitating recruitment of Pcf11p and regulating the torpedo exonuclease Rat1p [PDF]

Scientific Reports
Transcription cycle of RNA polymerase II (RNAPII) features three stages: initiation, elongation, and termination. Termination, closely linked with pre-mRNA 3’ processing, dissociates RNAPII from DNA and releases the nascent RNA transcript.
Riddhi Mehta, Fatema Zohra Sadia, Suprataptha U. Reddy, Ivana Vancurova, Ales Vancura   +4 more
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Elongation/Termination Factor Exchange Mediated by PP1 Phosphatase Orchestrates Transcription Termination

Cell Reports, 2018
Summary: Termination of RNA polymerase II (Pol II) transcription is a key step that is important for 3′ end formation of functional mRNA, mRNA release, and Pol II recycling. Even so, the underlying termination mechanism is not yet understood.
Tea Kecman, Krzysztof Kuś, Dong-Hyuk Heo, Katie Duckett, Adrien Birot, Sabrina Liberatori, Shabaz Mohammed, Lucia Geis-Asteggiante, Carol V. Robinson, Lidia Vasiljeva   +9 more
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Conserved 3′ stem-loop structures enable comprehensive analysis of bacterial transcription termination in metagenomes [PDF]

Microbiome
Background Bacterial transcription termination is a critical yet underexplored layer of gene regulation in microbial ecosystems. Existing computational tools, however, primarily focus on predicting transcript 3′ ends generated by Rho-independent ...
Yunfan Jin, Jiyun Cui, Rulong Liu, Hongli Ma, Xiaomin Xu, Shufang Wu, Fei Gan, Zhi John Lu, Zhenjiang Zech Xu   +8 more
doaj   +2 more sources

Transcription termination and readthrough in African swine fever virus [PDF]

Frontiers in Immunology
IntroductionAfrican swine fever virus (ASFV) is a nucleocytoplasmic large DNA virus (NCLDV) that encodes its own host-like RNA polymerase (RNAP) and factors required to produce mature mRNA.
Gwenny Cackett, Michal Sýkora, Raquel Portugal, Christopher Dulson, Linda Dixon, Finn Werner   +5 more
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Nucleotide-induced hyper-oligomerization inactivates transcription termination factor ρ [PDF]

Nature Communications
Bacterial RNA helicase ρ is a genome sentinel that terminates the synthesis of damaged and junk RNAs that are not translated by the ribosome. It is unclear how ρ is regulated during dormancy or stress, when translation is inefficient and RNAs are ...
Bing Wang, Nelly Said, Tarek Hilal, Mark Finazzo, Markus C. Wahl, Irina Artsimovitch   +5 more
doaj   +2 more sources

Single-molecule reconstruction of eukaryotic factor-dependent transcription termination [PDF]

Nature Communications
Factor-dependent termination uses molecular motors to remodel transcription machineries, but the associated mechanisms, especially in eukaryotes, are poorly understood.
Ying Xiong, Weijing Han, Chunhua Xu, Jing Shi, Lisha Wang, Taoli Jin, Qi Jia, Ying Lu, Shuxin Hu, Shuo-Xing Dou, Wei Lin, Terence R. Strick, Shuang Wang, Ming Li   +13 more
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PP1/PNUTS phosphatase binds the restrictor complex and stimulates RNA Pol II transcription termination [PDF]

Cell Reports
Summary: The restrictor ZC3H4/WDR82 terminates antisense transcription from bidirectional promoters, but its mechanism is poorly understood. We report that ZC3H4/WDR82 immunoprecipitates with PP1 phosphatase and its nuclear targeting subunit, PP1 ...
Benjamin Erickson, Roman Fedoryshchak, Nova Fong, Ryan Sheridan, Keira Y. Larson, Anthony J. Saviola, Stephane Mouilleron, Kirk C. Hansen, Richard Treisman, David L. Bentley   +9 more
doaj   +2 more sources

Premature termination of transcription is shaped by Rho and translated uORFS in Mycobacterium tuberculosis

iScience, 2023
Summary: Little is known about the decisions behind transcription elongation versus termination in the human pathogen Mycobacterium tuberculosis (M.TB). By applying Term-seq to M.TB we found that the majority of transcription termination is premature and
Alexandre D’Halluin, Peter Polgar, Terry Kipkorir, Zaynah Patel, Teresa Cortes, Kristine B. Arnvig   +5 more
doaj   +1 more source