Results 21 to 30 of about 990,842 (289)
ARTDeco: automatic readthrough transcription detection
BMC Bioinformatics, 2020 Background Mounting evidence suggests several diseases and biological processes target transcription termination to misregulate gene expression. Disruption of transcription termination leads to readthrough transcription past the 3′ end of genes, which ...
Samuel J. Roth +2 more
doaj +1 more source
Rho-dependent transcription termination proceeds via three routes
Nature Communications, 2022 Rho is a general transcription termination factor in bacteria. Here, Song et al. use single-molecule fluorescence assays to provide evidence that Rho-mediated transcription termination can occur via three kinetically different routes.
Eunho Song +7 more
doaj +1 more source
Derailing the Locomotive: Transcription Termination [PDF]
Journal of Biological Chemistry, 2008 Transcription can be divided into three stages: initiation, elongation, and termination. Initiation involves the binding of RNA polymerase (RNAP)2 to a gene’s promoter and the beginning of RNA synthesis. Elongation involves lengthening the nascent transcript by the addition of nucleotides to the 3 -end of the RNA located in the active site of RNAP. The
David S, Gilmour, Ruopeng, Fan
openaire +2 more sources
Functional characterization of Ysh1p, the yeast endonuclease involved in 3" end processing and in transcription termination of RNA polymerase II transcripts [PDF]
, 2008 Eukaryotic RNA polymerase II (RNAP II) is involved in the synthesis of two major classes of transcripts: messenger RNAs (mRNAs) and small nuclear and small nucleolar RNAs.
Garas, Monika
core +1 more source
Transcriptional termination enhances protein expression in human cells [PDF]
, 2009 Transcriptional termination of mammalian RNA polymerase II (Pol II) requires a poly(A) (pA) signal and, often, a downstream terminator sequence. Termination is triggered following recognition of the pA signal by Pol II and subsequent pre-mRNA cleavage ...
Proudfoot, Nicholas J +4 more
core +1 more source
Rho-dependent terminators and transcription termination [PDF]
Microbiology, 2006 Rho-dependent transcription terminators participate in sophisticated genetic regulatory mechanisms, in both bacteria and phages; they occur in regulatory regions preceding the coding sequences of genes and within coding sequences, as well as at the end of transcriptional units, to prevent readthrough transcription.
openaire +2 more sources
F1000Research, 2016 Transcription termination is a fundamental process in which RNA polymerase ceases RNA chain extension and dissociates from the chromatin template, thereby defining the end of the transcription unit. Our understanding of the biological role and functional
Travis J. Loya, Daniel Reines
doaj +1 more source
The transcription and export complex THO/TREX contributes to transcription termination in plants.
PLoS Genetics, 2020 Transcription termination has important regulatory functions, impacting mRNA stability, localization and translation potential. Failure to appropriately terminate transcription can also lead to read-through transcription and the synthesis of antisense ...
Ghazanfar Abbas Khan +9 more
doaj +1 more source
Analyses of the archaeal transcription cycle reveal a mosaic of eukaryotic RNA polymerase II and III-like features [PDF]
, 2009 Novel mechanistic properties of the archaeal transcription system that reveal similarities especially to the eukaryotic RNA polymerase II and III systems were presented in thesis.
Spitalny, Patrizia
core +1 more source
PLoS Genetics, 2020 Base J, β-D-glucosyl-hydroxymethyluracil, is a modification of thymine DNA base involved in RNA Polymerase (Pol) II transcription termination in kinetoplastid protozoa.
Rudo Kieft +7 more
doaj +1 more source