Results 51 to 60 of about 990,842 (289)

Transcription termination and anti‐termination in E. coli [PDF]

Genes to Cells, 2002
Transcription termination in Escherichia coli is controlled by many factors. The sequence of the DNA template, the structure of the transcript, and the actions of auxiliary proteins all play a role in determining the efficiency of the process. Termination is regulated and can be enhanced or suppressed by host and phage proteins.
Evgeny, Nudler, Max E, Gottesman
openaire   +2 more sources

An integrated model for termination of RNA polymerase III transcription

, 2021
RNA polymerase III (RNAPIII) synthesizes essential and abundant non-coding RNAs such as tRNAs. Controlling RNAPIII span of activity by accurate and efficient termination is a challenging necessity to ensure robust gene expression and to prevent conflicts
Müller, Christoph, Porrua, O, Xie, J, Pena, Vlad, Girbig, Mathias, Haidara, N, Girbig, M, Porrua, Odil, Schmitzova, Jana, Clement, Yves, Pena, Vladimir, Müller, CW, Libri, D, Aiello, U, Schmitzova, J, Haidara, Nouhou, Clement, Y, Libri, Domenico, Müller, Christoph W., Pena, V, Xie, Juanjuan, Aiello, Umberto   +21 more
core   +1 more source

The Bacillus subtilis TRAP protein can induce transcription termination in the leader region of the tryptophan biosynthetic (trp) operon independent of the trp attenuator RNA. [PDF]

PLoS ONE, 2014
In Bacillus subtilis, transcription of the tryptophan biosynthetic operon is regulated by an attenuation mechanism. When intracellular tryptophan levels are high, the TRAP protein binds to the 5' leader region of the nascent trp mRNA and induces ...
Natalie M McAdams, Paul Gollnick
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Transcription Factors and Termination of Transcription in Methanococcus [PDF]

Systematic and Applied Microbiology, 1993
Summary We have recently shown that specific transcription in cell extracts of Methanococcus thermolithotrophicus depends upon a transcription factor that was separated from the RNA polymerase by phosphocellulose chromatography. Here, we provide evidence for a second transcription factor.
Michael Thomm, Winfried Hausner, Carina Hethke   +2 more
openaire   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Time-resolved analysis of transcription kinetics in single live mammalian cells

Frontiers in Physics, 2022
In eukaryotic cells, RNA polymerase II synthesizes mRNA in three stages, initiation, elongation, and termination, and numerous factors determine how quickly a gene is transcribed to produce mRNA molecules through these steps.
Hongyoung Choi, Byung Hun Lee, Hye Yoon Park, Hye Yoon Park, Hye Yoon Park   +4 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

WebGeSTer DB—a transcription terminator database [PDF]

Nucleic Acids Research, 2010
We present WebGeSTer DB, the largest database of intrinsic transcription terminators (http://pallab.serc.iisc.ernet.in/gester). The database comprises of a million terminators identified in 1060 bacterial genome sequences and 798 plasmids. Users can obtain both graphic and tabular results on putative terminators based on default or user-defined ...
Anirban Mitra, Anil K. Kesarwani, Debnath Pal, Valakunja Nagaraja   +3 more
openaire   +2 more sources

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source