Results 61 to 70 of about 990,842 (289)
eLife, 2018 Codon usage biases are found in all genomes and influence protein expression levels. The codon usage effect on protein expression was thought to be mainly due to its impact on translation.
Zhipeng Zhou +4 more
doaj +1 more source
Sen1 Is Recruited to Replication Forks via Ctf4 and Mrc1 and Promotes Genome Stability
Cell Reports, 2020 Summary: DNA replication and RNA transcription compete for the same substrate during S phase. Cells have evolved several mechanisms to minimize such conflicts.
Rowin Appanah +4 more
doaj +1 more source
Histone H3 Variant Regulates RNA Polymerase II Transcription Termination and Dual Strand Transcription of siRNA Loci in Trypanosoma brucei. [PDF]
PLoS Genetics, 2016 Base J, β-D-glucosyl-hydroxymethyluracil, is a chromatin modification of thymine in the nuclear DNA of flagellated protozoa of the order Kinetoplastida. In Trypanosoma brucei, J is enriched, along with histone H3 variant (H3.V), at sites involved in RNA ...
David Reynolds +6 more
doaj +1 more source
Genome transcription/translation of segmented, negative-strand RNA viruses [PDF]
, 2011 The requirements for alignment of capped RNA leader sequences along the viral genome during influenza transcription initiation (“cap-snatching”) have long been an enigma.
Geerts-Dimitriadou, C.
core
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Frontiers in Cell and Developmental Biology, 2021 In Trypanosoma brucei, genes are assembled in polycistronic transcription units (PTUs). Boundaries of PTUs are designated transcription start sites and transcription termination sites (TTSs).
Hee-Sook Kim
doaj +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
The exosome component Rrp6 is required for RNA polymerase II termination at specific targets of the Nrd1-Nab3 pathway. [PDF]
PLoS Genetics, 2015 The exosome and its nuclear specific subunit Rrp6 form a 3'-5' exonuclease complex that regulates diverse aspects of RNA biology including 3' end processing and degradation of a variety of noncoding RNAs (ncRNAs) and unstable transcripts.
Melanie J Fox +4 more
doaj +1 more source
UNCOVERING THE MECHANISM OF CHROMATIN ASSOCIATION OF THE PAF1 TRANSCRIPTION ELONGATION COMPLEX [PDF]
, 2013 Paf1C co-localizes with Pol II and influences gene expression by regulating transcription initiation, elongation and termination. Some crucial functions of Paf1C include promoting co-transcriptional histone modifications and recruiting termination ...
Mayekar, Manasi
core
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source