Results 251 to 260 of about 5,966,093 (336)

A calcineurin-dependent transcriptional pathway for cardiac hypertrophy.

Cell, 1998
Jeffery D. Molkentin, Jeffery D. Molkentin, Jian-rong Lu, C. Antos, B. Markham, J. Richardson, J. Robbins, S. R. Grant, E. Olson   +8 more
semanticscholar   +1 more source

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

FEBS Open Bio, EarlyView.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source

Nuclear basket proteins Nup2 and Mlp1 drive heat shock-induced 3D genome restructuring downstream of transcriptional activation. [PDF]

J Biol Chem
Mohajan S, Rubio LS, Gross DS.
europepmc   +1 more source

Nuclear CDKs drive Smad transcriptional activation and turnover in BMP and TGF-beta pathways.

Cell, 2009
Claudio R. Alarcón, A. Zaromytidou, Q. Xi, Sheng Gao, Jianzhong Yu, S. Fujisawa, A. Barlas, Alexandria N. Miller, K. Manova-Todorova, M. Macias, Gopal P. Sapkota, D. Pan, J. Massagué   +12 more
semanticscholar   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

LncRNA PVT1 promotes cuproptosis through transcriptional activation of FDX1 in colorectal cancer. [PDF]

Redox Biol
Ma J, Zhang Y, Sun Z, Guo H, Li X, Cai J, Zhang M, Chen M, Jiang J, Zhang L.   +9 more
europepmc   +1 more source

The EDLL motif: a potent plant transcriptional activation domain from AP2/ERF transcription factors.

The Plant Journal, 2012
Shiv B. Tiwari, Alemu Belachew, Siu Fong Ma, M. Young, J. Ade, Yu Shen, Colleen M. Marion, H. Holtan, A. Bailey, J. Stone, Leslie Edwards, Andreah D. Wallace, R. Canales, L. Adam, O. Ratcliffe, P. Repetti   +15 more
semanticscholar   +1 more source

Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes

FEBS Open Bio, EarlyView.
We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde, Unai Alduntzin, Gorka Prieto, Ugo Mayor   +3 more
wiley   +1 more source

Enhanced Transcriptional Activation in Developing Mouse Photoreceptors. [PDF]

Invest Ophthalmol Vis Sci
Patierno BM, Emerson MM.
europepmc   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source