Results 271 to 280 of about 192,584 (302)

Transcript elongation factors: shaping transcriptomes after transcript initiation

Trends in Plant Science, 2014
Elongation is a dynamic and highly regulated step of eukaryotic gene transcription. A variety of transcript elongation factors (TEFs), including modulators of RNA polymerase II (RNAPII) activity, histone chaperones, and histone modifiers, have been characterized from plants.
Mieke, Van Lijsebettens, Klaus D, Grasser   +1 more
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Mechanisms of Transcription Elongation Factor DSIF (Spt4–Spt5)

Journal of Molecular Biology, 2021
The transcription elongation factor Spt5 is conserved from bacteria to humans. In eukaryotes, Spt5 forms a complex with Spt4 and regulates processive transcription elongation. Recent studies on transcription elongation suggest different mechanistic roles in yeast versus mammals.
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Cellular dynamics of the negative transcription elongation factor NELF

Experimental Cell Research, 2009
Negative Elongation Factor (NELF) is a transcription factor discovered based on its biochemical activity to suppress transcription elongation, and has since been implicated in various diseases ranging from neurological disorders to cancer. Besides its role in promoter-proximal pausing of RNA polymerase II during early stages of transcription, recently ...
Tetsu M C, Yung, Takashi, Narita, Toshiharu, Komori, Yuki, Yamaguchi, Hiroshi, Handa   +4 more
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Transcription Elongation Factors Repress Transcription Initiation from Cryptic Sites

Science, 2003
Previous studies have suggested that transcription elongation results in changes in chromatin structure. Here we present studies of Saccharomyces cerevisiae Spt6, a conserved protein implicated in both transcription elongation and chromatin structure. Our results show that, surprisingly, an
Craig D, Kaplan, Lisa, Laprade, Fred, Winston   +2 more
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Transcript Elongation Factor TFIIS Is Involved in Arabidopsis Seed Dormancy

Journal of Molecular Biology, 2009
Transcript elongation factor TFIIS promotes efficient transcription by RNA polymerase II, since it assists in bypassing blocks during mRNA synthesis. While yeast cells lacking TFIIS are viable, inactivation of mouse TFIIS causes embryonic lethality. Here, we have identified a protein encoded in the Arabidopsis genome that displays a marked sequence ...
Grasser, Marion, Kane, Caroline M., Merkle, Thomas, Melzer, Michael, Emmersen, Jeppe, Grasser, Klaus D.   +5 more
openaire   +4 more sources

Transcription elongation factor S-II is not required for transcription-coupled repair in yeast

Molecular and General Genetics MGG, 1997
Two different subpathways play a role in removal of UV-induced cyclobutane pyrimidine dimers (CPDs) by nucleotide excision repair (NER). The relatively slow global genome repair subpathway operates on all CPDs irrespective of their position in the DNA, whereas the transcription-coupled repair subpathway is responsible for the rapid removal of CPDs from
R A, Verhage, J, Heyn, P, van de Putte, J, Brouwer   +3 more
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Characterization of the gene encoding the human transcriptional elongation factor TFIIS

Gene, 1994
The transcriptional elongation factor TFIIS causes stimulation of RNA polymerase II elongation and readthrough of some of the elongation blocks. We present cloning and sequence characterization of the human TFIIS gene and a pseudogene. The intron-less organization of both of these genes indicates that previously identified cDNAs which suggested the ...
PARK, HR, BAEK, KH, JEON, CJ, AGARWAL, K, YOO, OJ Yoo, Ook-Joon   +4 more
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Characterization of Toxoplasma gondii Spt5 like transcription elongation factor

Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2019
Elongation has emerged as a highly regulated step in the multistage process of transcription. Control of gene expression mediated through transcription elongation remains an unexplored area of study in Toxoplasma gondii where the demands of complex lifecycle necessitate a regulated transcription program.
Pallabi, Mitra, Abhijit S, Deshmukh, Rajkumar, Gurupwar, Poonam, Kashyap   +3 more
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Alanine-Scanning Mutagenesis of Human Transcript Elongation Factor TFIIS

Biochemistry, 1995
TFIIS is a transcription elongation factor that binds to RNA polymerase II and allows it to transcribe through a variety of transcriptional blockages by inducing cleavage near the 3' end of the nascent transcript. Although this cleavage reaction plays a key role in the process of reactivation of transcription by TFIIS, the exact mechanism by which ...
G, Cipres-Palacin, C M, Kane
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Transcriptional elongation control in developmental gene expression, aging, and disease

Molecular Cell, 2023
Yuki Aoi, Ali Shilatifard
exaly