Results 201 to 210 of about 5,670,610 (287)

Generalist Malaria Parasites and Host Imprinting: Unveiling Transcriptional Memory. [PDF]

Mol Biol Evol
García-Longoria L, Palinauskas V, Aželytė J, Marzal A, Ovelleiro D, Hellgren O.   +5 more
europepmc   +1 more source

Collagen‐Binding IL‐15 Immunocytokine Armed Oncolytic Adenovirus Establishes a Self‐Reinforcing Immunostimulatory Milieu to Potentiate Antitumor Immunity

Advanced Science, EarlyView.
Repurposing the dense tumor stroma from a physical barrier into an anchoring scaffold, an engineered oncolytic adenovirus encoding IL15C‐CBD overcomes the immunosuppressive microenvironment in triple‐negative breast cancer. Intratumoral viral replication secretes this collagen‐anchored immunocytokine, forming a localized cytokine depot.
Yaqi Yang, Xiaoxiao Liu, Junqiang Ding, Jinliang Xu, Jianhua Zhang, Hanchang Zhang, Rong Yang, Sha Li, Lu Zheng, Runping Su, Yue Zhao, Jianxiao Wu, Hao Li, Changyou Zhan, Xihui Gao   +14 more
wiley   +1 more source

Transcriptional memory dampens heat shock responses in yeast: functional role of Mip6 and its interaction with Rpd3. [PDF]

G3 (Bethesda)
Serrano-Quílez J, Tejada-Colón A, Nuño-Cabanes C, Rodríguez-Navarro S.   +3 more
europepmc   +1 more source

Fumarate Hydratase Lactylation Exacerbates Traumatic Brain Injury Pathology via Mitochondrial Dysfunction and Neuroinflammation

Advanced Science, EarlyView.
Tian et al. reveal that FH K112 lactylation is elevated after TBI, leading to fumarate accumulation, mitochondrial damage, mtDNA release and amplified neuroinflammation. AARS2 and SIRT3 act as the “writer” and “eraser” for FH K112 lactylation. The peptide Pep‐K112 targeting this site alleviates brain injury, highlighting a potential therapeutic target.
Yang Tian, Shuoyao Ma, Bo Yang, Fei Gao, Hao Guo, Haixiao Liu, Xun Wu, Wenxing Cui, Jingyu Dong, Qian Lin, Yufeng Ge, Jin Ma, Jiazhen Zhao, Yongzhi Zhang, Dongzhi Xue, Jiaxin Tian, Ziwen Zhang, Kai Wang, Meng Xu, Dayun Feng, Jinpeng Zhou, Yan Qu   +21 more
wiley   +1 more source

Short-term transcriptional memory and association-forming ability of tomato plants in response to ultrasound and drought stress stimuli. [PDF]

Plant Signal Behav
Farkas D, Király A, Ambrus V, Tóth B, Dobránszki J.   +4 more
europepmc   +1 more source

Transcriptional memory is conferred by combined heritable maintenance and local removal of selective chromatin modifications

, 2023
Mikulski P, Tehrani SS, Kogan A, Abdul-Zani I, Shell E, Ryan BJ, Jansen LE.   +6 more
europepmc   +1 more source

Upadacitinib Restrains the Pathogenic Fitness of CD4+ T Cells and Aberrant B Cell Programming in Optic Neuritis

Advanced Science, EarlyView.
Single‐cell profiling and functional perturbation reveal coordinated JAK1‐pSTAT3 downstream programs in optic neuritis, including MCL1‐dependent fitness of pathogenic CD4+ Tem cells and glycolysis‐linked, cholesterol‐sensitive B‐cell responses associated with RORA. Upadacitinib disrupts this reciprocal T‐B‐cell circuit and alleviates neuroinflammation,
Gengchen Jiang, Qi Jiang, Lian Han, Yue Peng, Xingyu Liu, Tong Yang, Hao Huang, Jiaying Liu, Yuan Gao, Hui Yang, Wenjun Zou, Zhaohuai Li, Wenru Su   +12 more
wiley   +1 more source

Spatiotemporally Controlled Sequential Chemo‐Immunotherapy Activates Pyroptosis for Robust Anti‐Tumor Immunotherapy

Advanced Science, EarlyView.
A glutathione and ultrasound dual‐responsive cerasome achieves sequential co‐delivery of gemcitabine and BMS1166 in tumors. Chemotherapy priming followed by on‐demand PD‐L1 blockade synergistically amplifies anti‐tumor immunity, inhibiting primary tumor growth, distant metastasis and inducing durable immune memory.
Suhui Sun, Ruiqi Wu, Qingshuang Tang, Yunli Xu, Wanrui Shi, Mengxin Wang, Haonan Wang, Yan Luo, Cheng Ma, Xiaolong Liang   +9 more
wiley   +1 more source

Experience-mediated transcriptional memory correlates with hypoxia resistance in the nervous system of the sea hare <i>Aplysia californica</i>. [PDF]

Am J Physiol Regul Integr Comp Physiol
Rodriguez-Casariego JA, Gillette P, Schmale M, Miller MW, Fieber LA.   +4 more
europepmc   +1 more source

Distinct heterochromatin-like domains promote transcriptional memory and silence parasitic genetic elements in bacteria. [PDF]

EMBO J, 2022
Amemiya HM, Goss TJ, Nye TM, Hurto RL, Simmons LA, Freddolino PL.   +5 more
europepmc   +1 more source