Results 211 to 220 of about 125,147 (241)

‘We Are Australia’: Unpacking Aboriginal and Torres Strait Islander People's Understandings and Experiences of Australian Identity

Australian Journal of Social Issues, EarlyView.
ABSTRACT Aboriginal and Torres Strait Islander people are the oldest living custodians in the world. However, Australian identity has been purposefully established to exclude Aboriginal and Torres Strait Islander people, contributing to systemic oppression and harmful consequences. Understanding the perspectives and experiences of Aboriginal and Torres
Jack Farrugia, Jonathan Bullen
wiley   +1 more source

Zebrafish and CRISPR—A synergistic approach to decipher and cure human diseases

Animal Models and Experimental Medicine, EarlyView.
Zebrafish, with high genetic homology to humans, serves as a powerful vertebrate model for disease modeling and drug discovery. Integration of CRISPR/Cas9 technology enables precise genome editing, facilitating the development of translational models for human diseases.
Manikandan Sivaprakasam, Aashika Raagavi Jeanpierre, Salma Mohammed, Rajesh Srinivasan, Aman Kumar Mohanty   +4 more
wiley   +1 more source

Scalp electroacupuncture targeting trigeminal nerve activation alleviates post‐traumatic stress disorder–induced depression and neuroinflammation in mice

Animal Models and Experimental Medicine, EarlyView.
Scalp electroacupuncture (SA) through activation of the trigeminal pathway exerts anti‐inflammatory, antidepressant, and anxiolytic effects in an animal model of post‐traumatic stress disorder induced by single prolonged stress. This suggests that SA is involved in neuroinflammation and changes in brain‐derived neurotrophic factor protein through the ...
Bombi Lee, Yoongeun Kim, Hyungjun Kim, Dae‐Hyun Hahm   +3 more
wiley   +1 more source

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Mechanisms of transcriptional memory

Nature Reviews Molecular Cell Biology, 2001
How can the same gene remember that it is 'off' in one cell lineage and 'on' in another? Studies of how homeotic genes are regulated in Drosophila melanogaster have uncovered a transcriptional maintenance system, encoded by the Polycomb and trithorax group genes, that preserves expression patterns across development.
N J, Francis, R E, Kingston
openaire   +2 more sources

Potential memory and hysteretic effects in transcription

Journal of Theoretical Biology, 1988
Kinetic results of RNA-chain elongation catalysed by wheat-germ RNA polymerase II are analysed according to the concept that DNA-dependent conformational transitions of the transcription complex intervene during transcription. A model is presented, involving participation of several forms of the transcription complex with different catalytic properties,
D, Job, J M, Soulié, C, Job, D, Shire
openaire   +2 more sources

Transcriptional Regulation Involved in Fear Memory Reconsolidation

Journal of Molecular Neuroscience, 2018
Memory reconsolidation has been demonstrated to offer a potential target period during which the fear memories underlying fear disorders can be disrupted. Reconsolidation is a labile stage that consolidated memories re-enter after memories are reactivated.
Xu Wang, Min Li, Haitao Zhu, Yongju Yu, Yuanyuan Xu, Wenmo Zhang, Chen Bian   +6 more
openaire   +2 more sources

Role of a transcription factor (CREB) in memory processes.

Rivista di biologia, 1998
Memory storage includes a short-term phase (STM) which requires the phosphorylation of pre-existing proteins, and a long-term phase (LTM) which needs the novel synthesis of RNA and proteins. Cyclic AMP and a specific transcription factor (cAMP response element binding protein or CREB) play a central role in the formation of LTM in aplysia, drosophila ...
De Luca, Antonella, Giuditta, Antonio
openaire   +2 more sources

Theory on the dynamic memory in the transcription-factor-mediated transcription activation

Physical Review E, 2011
We develop a theory to explain the origin of the static and dynamical memory effects in transcription-factor-mediated transcription activation. Our results suggest that the following inequality conditions should be satisfied to observe such memory effects: (a) τ(L)≫max(τ(R),τ(E)), (b) τ(LT)≫τ(T), and (c) τ(I)≥(τ(EL)+τ(TR)) where τ(L) is the average ...
openaire   +2 more sources

Thalamocortical transcriptional gates coordinate memory stabilization

Nature
The molecular mechanisms that enable memories to persist over long timescales from days to weeks and months are still poorly understood1. Here, to develop insights into this process, we created a behavioural task in which mice formed multiple memories but only consolidated some, while forgetting others, over the span of weeks. We then monitored circuit-
Andrea Terceros, Celine Chen, Yujin Harada, Tim Eilers, Millennium Gebremedhin, Pierre-Jacques Hamard, Richard Koche, Roshan Sharma, Priya Rajasethupathy   +8 more
openaire   +2 more sources

Transcription factors that regulate memory in humoral responses

Immunological Reviews, 2006
Summary:  At least three types of B lymphocytes are important for providing memory in a humoral immune response: ‘classical’ memory cells that do not secrete immunoglobulin (Ig), long‐lived plasma cells (LLPCs) in the bone marrow, and ‘innate‐like’ B‐1 cells.
openaire   +2 more sources