Results 41 to 50 of about 1,358,415 (326)
Understanding the role of chromatin remodeling in the regulation of circadian transcription in Drosophila. [PDF]
, 2015 Circadian clocks enable organisms to anticipate daily changes in the environment and coordinate temporal rhythms in physiology and behavior with the 24-h day-night cycle. The robust cycling of circadian gene expression is critical for proper timekeeping,
Chiu, Joanna C +2 more
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R-loops in normal and malignant hematopoiesis
Frontiers in Hematology, 2023 An R-loop is a nucleic acid structure consisting of a DNA : RNA hybrid and single-stranded DNA. It is formed physiologically in normal cells and is involved in transcription, replication, and gene rearrangement; in particular, it has multiple roles ...
Mayumi Hirayama +3 more
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Global landscape of mouse and human cytokine transcriptional regulation [PDF]
, 2018 Cytokines are cell-to-cell signaling proteins that play a central role in immune development, pathogen responses, and diseases. Cytokines are highly regulated at the transcriptional level by combinations of transcription factors (TFs) that recruit ...
Fuxman Bass, Juan Ignacio +8 more
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Nature Communications, 2017 CD4 and CD8 T cells develop in the thymus with their transcription programs controlled by ThPOK and Runx3, respectively. Here the authors show that a pre-commitment event modulated by the transcription factor, Bcl11b, is required for the proper ...
Satoshi Kojo +18 more
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Frontiers in Cell and Developmental Biology, 2022 The cladoceran crustacean Daphnia produces only females by parthenogenesis in a healthy population. However, in response to environmental declines such as crowding and lack of foods, it produces eggs destined to become males that are genetically ...
Yasuhiko Kato, Hajime Watanabe
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Transcriptional Regulation by P53 [PDF]
Cold Spring Harbor Perspectives in Biology, 2010 Inactivation of p53 is critical for the formation of most tumors. Illumination of the key function(s) of p53 protein in protecting cells from becoming cancerous is therefore a worthy goal. Arguably p53's most important function is to act as a transcription factor that directly regulates perhaps several hundred of the cell's RNA polymerase II (RNAP II ...
Rachel, Beckerman, Carol, Prives
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mSphere, 2016 In view of emerging drug resistance among bacterial pathogens, including Mycobacterium tuberculosis, the development of novel therapeutic strategies is increasingly being sought.
Pallavi Chandra +4 more
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Regulation of HSV Transcription.
Journal of Investigative Dermatology, 1984 Herpes simplex virus (HSV) transcripts share many features with both cellular mRNA and the mRNAs expressed by other nuclear-replicating DNA viruses: they are capped, polyadenylated, and generally have an approximately 150 base leader between the cap and translation initiation codon.
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Transcriptional memory emerges from cooperative histone modifications [PDF]
, 2011 Background Transcriptional regulation in cells makes use of diverse mechanisms to ensure that functional states can be maintained and adapted to variable environments; among them are chromatin-related mechanisms.
Hans Binder +4 more
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Diffusion, dimensionality and noise in transcriptional regulation
, 2007 The precision of biochemical signaling is limited by randomness in the diffusive arrival of molecules at their targets. For proteins binding to the specific sites on the DNA and regulating transcription, the ability of the proteins to diffuse in one ...
E. M. Lifshitz +4 more
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