Results 331 to 340 of about 345,542 (371)

Wedelolactone, a Novel TLR2 Agonist, Promotes Neutrophil Differentiation and Ameliorates Neutropenia: A Multi‐Omics Approach to Unravel the Mechanism

Advanced Science, EarlyView.
Wedelolactone (WED), a natural TLR2 agonist, promotes neutrophil differentiation and enhances bactericidal function, offering a potential therapeutic strategy for neutropenia. Using a multi‐omics approach, this study reveals that WED activates the TLR2/MEK/ERK pathway, upregulating key transcription factors (PU.1, CEBPβ) to drive neutrophil development.
Long Wang, Zhichao Li, Tianci Hu, Qinyao Li, Linwei Zhang, Xinyue Mei, Xiao Qi, Sheng Liu, Weijie Kong, Jiesi Luo, Anguo Wu, Feihong Huang, Sirui Li, Shuang Dai, Chunxiang Zhang, Rong Li, Jianming Wu   +16 more
wiley   +1 more source

Cinnamic‐Hydroxamic‐Acid Derivatives Exhibit Antibiotic, Anti‐Biofilm, and Supercoiling Relaxation Properties by Targeting Bacterial Nucleoid‐Associated Protein HU

Advanced Science, EarlyView.
Cinnamic‐hydroxamic‐acid derivatives (CHADs) are identified as novel inhibitors of the bacterial nucleoid‐associated protein HU, exhibiting potent antibacterial, anti‐biofilm (both inhibition and eradication), and DNA relaxation (anti‐supercoiling) activities. Moreover, CHADs demonstrate strong synergistic effects with multiple antibiotics.
Huan Chen, Yingqi Xu, Zhaoping Xiong, Hongliang Wang, Xin Wang, Yue Kang, Zhonglin Wang, Xiaoyan Zeng, Yahui Liu, Yehuan Zheng, Wei Chen, Mengzhe Li, Zhenyue Hu, Chi Xu, Yue Wu, Yawen Wang, Zuyi Yuan, Shuai Yuan, Huadong Liu, Steve Matthews, Nan Qiao, Yan Li, Bing Liu   +22 more
wiley   +1 more source

Transcriptome-wide association study and Mendelian randomization in pancreatic cancer identifies susceptibility genes and causal relationships with type 2 diabetes and venous thromboembolism. [PDF]

EBioMedicine
Tan MCB, Isom CA, Liu Y, Trégouët DA, INVENT Consortium, Wu L, Zhou D, Gamazon ER.   +7 more
europepmc   +1 more source

A cross-tissue transcriptome-wide association study identifies new susceptibility genes for insomnia

Li Li, Dongjin Wu, Cuiping Zhang, Xiaokun Lai, Ruolan Zhang, Shuhui Hu, Yifeng Ye   +6 more
openalex   +1 more source

Additional file 7 of A cross-tissue transcriptome-wide association study identifies novel candidate genes associated with brain glymphatic system function

Zhu, Xiaoyang, Wang, Shengjie, Zhang, Shuaiqi, Liu, Zhiyuan, Wang, Na, Wang, Shu, Yang, Nixia   +6 more
openalex   +1 more source

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Multitrait transcriptome‐wide association study (TWAS) tests

Genetic Epidemiology, 2021
AbstractMultitrait tests can improve power to detect associations between individual single‐nucleotide polymorphisms (SNPs) and several related traits. Here, we develop methods for multi‐SNP transcriptome‐wide association (TWAS) tests to test the association between predicted gene expression levels and multiple phenotypes.
Helian Feng, Nicholas Mancuso, Bogdan Pasaniuc, Peter Kraft   +3 more
openaire   +2 more sources

Transcriptome wide association studies: general framework and methods

Quantitative Biology, 2021
BackgroundGenome‐wide association studies (GWAS) have succeeded in identifying tens of thousands of genetic variants associated with complex human traits during the past decade, however, they are still hampered by limited statistical power and difficulties in biological interpretation.
Yuhan Xie, Nayang Shan, Hongyu Zhao, Lin Hou   +3 more
openaire   +1 more source

A cross-tissue transcriptome-wide association study identifies novel susceptibility genes for lung cancer in Chinese populations.

Human Molecular Genetics, 2021
Although dozens of susceptibility loci have been identified for lung cancer in genome-wide association studies (GWASs), the susceptibility genes and underlying mechanisms remain unclear.
Meng Zhu, Jingyi Fan, Chang Zhang, Jing Xu, R. Yin, E. Zhang, Yuzhuo Wang, M. Ji, Qi Sun, J. Dai, G. Jin, Liang Chen, Lin Xu, Zhibin Hu, Hongxia Ma, Hongbing Shen   +15 more
semanticscholar   +1 more source

Brain transcriptome-wide association study implicates novel risk genes underlying schizophrenia risk

Psychological Medicine, 2023
Background To identify risk genes whose expression are regulated by the reported risk variants and to explore the potential regulatory mechanism in schizophrenia (SCZ).
Chengcheng Zhang, Xiao-jing Li, Lian-sheng Zhao, Wan-jun Guo, W. Deng, Qiang Wang, Xun Hu, Xiangdong Du, P. Sham, Xiongjian Luo, Tao Li   +10 more
semanticscholar   +1 more source