Results 1 to 10 of about 6,140 (191)

A large-scale transcriptome-wide association study (TWAS) of 10 blood cell phenotypes reveals complexities of TWAS fine-mapping. [PDF]

Genet Epidemiol, 2022
Hematological measures are important intermediate clinical phenotypes for many acute and chronic diseases and are highly heritable. Although genome‐wide association studies (GWAS) have identified thousands of loci containing trait‐associated variants ...
Tapia AL, Rowland BT, Rosen JD, Preuss M, Young K, Graff M, Choquet H, Couper DJ, Buyske S, Bien SA, Jorgenson E, Kooperberg C, Loos RJF, Morrison AC, North KE, Yu B, Reiner AP, Li Y, Raffield LM.   +18 more
europepmc   +5 more sources

A large-scale transcriptome-wide association study (TWAS) of ten blood cell phenotypes reveals complexities of TWAS fine-mapping [PDF]

bioRxiv, 2021
Hematological measures are important intermediate clinical phenotypes for many acute and chronic diseases. Hematological measures are highly heritable, and although genome-wide association studies (GWAS) have identified thousands of loci containing trait-
Amanda L. Tapia, Bryce Rowland, Jonathan D. Rosen, Michael Preuß, Kris Young, Misa Graff, Hélène Choquet, David Couper, Steven Buyske, Stephanie A. Bien, Eric Jorgenson, Charles Kooperberg, Ruth J. F. Loos, Alanna C. Morrison, Kari E. North, Bing Yu, Alexander P. Reiner, Yun Li, Laura M. Raffield   +18 more
openalex   +2 more sources

Brain transcriptome wide association study (TWAS) implicates 8 genes across 6 loci in Alzheimer’s disease [PDF]

Alzheimer's & Dementia, 2020
Alzheimer’s disease (AD), an incurable neurodegenerative disease, currently affects 1.75% of the United States population, with projected growth to 3.46% by 2050.
Jake Gockley, Kelsey S. Montgomery, William L. Poehlman, Yue Liu, Ekaterina S. Gerasimov, Anna K. Greenwood, Aliza P. Wingo, Thomas S. Wingo, Lara M. Mangravite, Benjamin A. Logsdon   +9 more
openalex   +2 more sources

UTMOST, a single and cross-tissue TWAS (Transcriptome Wide Association Study), reveals new ASD (Autism Spectrum Disorder) associated genes [PDF]

Translational Psychiatry, 2021
Autism spectrum disorders (ASD) is a complex neurodevelopmental disorder that may significantly impact on the affected individual’s life. Common variation (SNPs) could explain about 50% of ASD heritability.
Cristina Rodríguez-Fontenla, Ángel Carracedo   +1 more
openalex   +2 more sources

SR-TWAS: leveraging multiple reference panels to improve transcriptome-wide association study power by ensemble machine learning [PDF]

Nature Communications
Multiple reference panels of a given tissue or multiple tissues often exist, and multiple regression methods could be used for training gene expression imputation models for transcriptome-wide association studies (TWAS). To leverage expression imputation
Randy L. Parrish, Aron S. Buchman, Shinya Tasaki, Yanling Wang, Denis Avey, Jishu Xu, Philip L. De Jager, David A. Bennett, Michael P. Epstein, Jingjing Yang   +9 more
openalex   +2 more sources

Identification of candidate genes and chemicals associated with osteoarthritis by transcriptome-wide association study and chemical-gene interaction analysis

Arthritis Research & Therapy, 2023
Background Osteoarthritis (OA) is a common degenerative joint disease and causes chronic pain and disability to the elderly. Several risk factors are involved, such as aging, obesity, genetic susceptibility, and environmental factors.
Lin Mei, Zhiming Zhang, Ruiqi Chen, Zhongyue Liu, Xiaolei Ren, Zhihong Li   +5 more
doaj   +2 more sources

Transcriptome-Wide Association Study of Metabolic Dysfunction-Associated Steatotic Liver Disease Identifies Relevant Gene Signatures

The Turkish Journal of Gastroenterology
Background/Aims: Metabolic dysfunction-associated steatotic liver disease (MASLD) is considered the most widespread chronic liver condition globally. Genome-wide association studies (GWAS) have pinpointed several genetic loci correlated to MASLD, yet the
Jianxiu Wang, Qian Gao
doaj   +2 more sources

Transcriptome-wide association study identifies genes associated with bladder cancer risk

Scientific Reports
Genome-wide association studies (GWAS) have detected several susceptibility variants for urinary bladder cancer, but how gene regulation affects disease development remains unclear.
Siting Li, Jiang Gui, Margaret R. Karagas, Michael N. Passarelli   +3 more
doaj   +2 more sources

Genome- and Transcriptome-Wide Association Studies Identify Susceptibility Genes and Pathways for Periodontitis

Cells, 2022
Several genes associated with periodontitis have been identified through genome-wide association studies (GWAS); however, known genes only explain a minority of the estimated heritability.
Guirong Zhu, Xing Cui, Liwen Fan, Yongchu Pan, Lin Wang   +4 more
doaj   +1 more source

Transcriptome-wide association study identified candidate genes associated with gut microbiota

Gut Pathogens, 2021
Background Gut microbiota is closely associated with host health and disease occurrence. Host genetic factor plays an important role in shaping gut microbial communities.
Chuyu Pan, Yujie Ning, Yumeng Jia, Shiqiang Cheng, Yan Wen, Xuena Yang, Peilin Meng, Chun’e Li, Huijie Zhang, Yujing Chen, Jingxi Zhang, Zhen Zhang, Feng Zhang   +12 more
doaj   +1 more source