Results 11 to 20 of about 6,140 (191)

Exploring Contraindicated Medications and Corresponding Targeted Genes for Migraine Through Integrated Genetic Approaches. [PDF]

Brain Behav
To systematically identify risk medications for migraine and its subtypes, we integrated GWAS data for 23 medications with GWASs of migraine and its subtypes to conduct causal inference. We then combined plasma eQTLs with drug‐target databases to map putative targets of the risk medications and validated causal relationships using colocalization and ...
Wang N, Liang W, Wen Z, Liao W, Xie Z, Zhou Z, Yang Z, Ju X, Zhou H, Huang C.   +9 more
europepmc   +2 more sources

A Transcriptome-Wide Association Study Identifies Candidate Susceptibility Loci and Genes for Lung Cancer Risk. [PDF]

Cancer Med
A transcriptome‐wide association study identified 40 genes associated with the risk of lung cancer, leveraging gene expression and genotype data from the Genotype‐Tissue Expression (GTEx) project and summary statistics of a genome‐wide association study on lung cancer.
Zhao T, Shi J, Yang Y, Zhou D, Ping J, Xu S, Xu L, Wu J, Shu XO, Tao R, Li B, Zheng W, Long J, Cai Q.   +13 more
europepmc   +2 more sources

Transcriptome-wide association studies: recent advances in methods, applications and available databases

Communications Biology, 2023
Genome-wide association study has identified fruitful variants impacting heritable traits. Nevertheless, identifying critical genes underlying those significant variants has been a great task.
Jialin Mai, Mingming Lu, Qianwen Gao, Jingyao Zeng, Jingfa Xiao   +4 more
doaj   +1 more source

Dissecting the genetic heterogeneity of gastric cancerResearch in context

EBioMedicine, 2023
Summary: Background: Gastric cancer (GC) is clinically heterogenous according to location (cardia/non-cardia) and histopathology (diffuse/intestinal). We aimed to characterize the genetic risk architecture of GC according to its subtypes.
Timo Hess, Carlo Maj, Jan Gehlen, Oleg Borisov, Stephan L. Haas, Ines Gockel, Michael Vieth, Guillaume Piessen, Hakan Alakus, Yogesh Vashist, Carina Pereira, Michael Knapp, Vitalia Schüller, Alexander Quaas, Heike I. Grabsch, Jessica Trautmann, Ewa Malecka-Wojciesko, Anna Mokrowiecka, Jan Speller, Andreas Mayr, Julia Schröder, Axel M. Hillmer, Dominik Heider, Florian Lordick, Ángeles Pérez-Aísa, Rafael Campo, Jesús Espinel, Fernando Geijo, Concha Thomson, Luis Bujanda, Federico Sopeña, Ángel Lanas, María Pellisé, Claudia Pauligk, Thorsten Oliver Goetze, Carolin Zelck, Julian Reingruber, Emadeldin Hassanin, Peter Elbe, Sandra Alsabeah, Mats Lindblad, Magnus Nilsson, Nicole Kreuser, René Thieme, Francesca Tavano, Roberta Pastorino, Dario Arzani, Roberto Persiani, Jin-On Jung, Henrik Nienhüser, Katja Ott, Ralf R. Schumann, Oliver Kumpf, Susen Burock, Volker Arndt, Anna Jakubowska, Małgorzta Ławniczak, Victor Moreno, Vicente Martín, Manolis Kogevinas, Marina Pollán, Justyna Dąbrowska, Antonio Salas, Olivier Cussenot, Anne Boland-Auge, Delphine Daian, Jean-Francois Deleuze, Erika Salvi, Maris Teder-Laving, Gianluca Tomasello, Margherita Ratti, Chiara Senti, Valli De Re, Agostino Steffan, Arnulf H. Hölscher, Katharina Messerle, Christiane Josephine Bruns, Armands Sīviņš, Inga Bogdanova, Jurgita Skieceviciene, Justina Arstikyte, Markus Moehler, Hauke Lang, Peter P. Grimminger, Martin Kruschewski, Nikolaos Vassos, Claus Schildberg, Philipp Lingohr, Karsten Ridwelski, Hans Lippert, Nadine Fricker, Peter Krawitz, Per Hoffmann, Markus M. Nöthen, Lothar Veits, Jakob R. Izbicki, Adrianna Mostowska, Federico Martinón-Torres, Daniele Cusi, Rolf Adolfsson, Geraldine Cancel-Tassin, Aksana Höblinger, Ernst Rodermann, Monika Ludwig, Gisela Keller, Andres Metspalu, Hermann Brenner, Joerg Heller, Markus Neef, Michael Schepke, Franz Ludwig Dumoulin, Lutz Hamann, Renato Cannizzaro, Michele Ghidini, Dominik Plaßmann, Michael Geppert, Peter Malfertheiner, Olivier Gehlen, Tomasz Skoczylas, Marek Majewski, Jan Lubiński, Orazio Palmieri, Stefania Boccia, Anna Latiano, Nuria Aragones, Thomas Schmidt, Mário Dinis-Ribeiro, Rui Medeiros, Salah-Eddin Al-Batran, Mārcis Leja, Juozas Kupcinskas, María A. García-González, Marino Venerito, Johannes Schumacher   +133 more
doaj   +1 more source

A Transcriptome-Wide Association Study (TWAS) Identifies Novel Candidate Susceptibility Genes for Pancreatic Cancer.

Journal of the National Cancer Institute, 2020
BACKGROUND Although 20 pancreatic cancer susceptibility loci have been identified through genome-wide association studies (GWAS) in individuals of European ancestry, much of its heritability remains unexplained and the genes responsible largely unknown.
Jun Zhong, Ashley A. Jermusyk, Lang Wu, J. Hoskins, I. Collins, E. Mocci, Mingfeng Zhang, Mingfeng Zhang, Lei Song, Charles C. Chung, Tongwu Zhang, Wenming Xiao, Wenming Xiao, D. Albanes, G. Andreotti, A. Arslan, A. Babic, W. Bamlet, L. Beane-Freeman, S. Berndt, A. Borgida, P. Bracci, L. Brais, P. Brennan, B. Bueno-de-Mesquita, J. Buring, J. Buring, F. Canzian, Erica J. Childs, M. Cotterchio, Mengmeng Du, E. Duell, C. Fuchs, S. Gallinger, J. Gaziano, Graham G. Giles, Graham G. Giles, Graham G. Giles, E. Giovannucci, M. Goggins, G. Goodman, P. Goodman, C. Haiman, P. Hartge, M. Hasan, K. Helzlsouer, E. Holly, E. Klein, M. Kogevinas, R. Kurtz, L. LeMarchand, N. Malats, S. Männistö, R. Milne, R. Milne, R. Milne, R. Neale, K. Ng, Ofure Obazee, A. Oberg, I. Orlow, Alpa V. Patel, U. Peters, Miquel Porta, Miquel Porta, N. Rothman, G. Scelo, G. Scelo, G. Scelo, H. Sesso, H. Sesso, G. Severi, S. Sieri, D. Silverman, M. Sund, A. Tjønneland, M. Thornquist, Geoffrey S. Tobias, A. Trichopoulou, S. Eeden, K. Visvanathan, J. Wactawski‐Wende, N. Wentzensen, Emily White, Emily White, Herbert Yu, C. Yuan, A. Zeleniuch‐Jacquotte, R. Hoover, K. Brown, C. Kooperberg, H. Risch, E. Jacobs, Donghui Li, Kai Yu, X. Shu, S. Chanock, B. Wolpin, R. Stolzenberg-Solomon, Nilanjan Chatterjee, Nilanjan Chatterjee, A. Klein, Jill P. Smith, P. Kraft, Jianxin Shi, G. Petersen, W. Zheng, L. Amundadottir   +107 more
semanticscholar   +1 more source

Population-Matched Transcriptome Prediction Increases TWAS Discovery and Replication Rate

iScience, 2020
Summary: Most genome-wide association studies (GWAS) and transcriptome-wide association studies (TWAS) focus on European populations; however, these results cannot always be accurately applied to non-European populations due to genetic architecture ...
Elyse Geoffroy, Isabelle Gregga, Heather E. Wheeler   +2 more
doaj   +1 more source

MiXcan: a framework for cell-type-aware transcriptome-wide association studies with an application to breast cancer

Nature Communications, 2023
Conventional transcriptome-wide association study (TWAS) approaches predict genetically regulated gene expression at the tissue level. Here, the authors develop a framework for cell-type-aware TWAS that predicts cell-type level expression from genotype ...
Xiaoyu Song, Jiayi Ji, Joseph H. Rothstein, Stacey E. Alexeeff, Lori C. Sakoda, Adriana Sistig, Ninah Achacoso, Eric Jorgenson, Alice S. Whittemore, Robert J. Klein, Laurel A. Habel, Pei Wang, Weiva Sieh   +12 more
doaj   +1 more source

Novel Variance-Component TWAS method for studying complex human diseases with applications to Alzheimer's dementia.

PLoS Genetics, 2021
Transcriptome-wide association studies (TWAS) have been widely used to integrate transcriptomic and genetic data to study complex human diseases. Within a test dataset lacking transcriptomic data, traditional two-stage TWAS methods first impute gene ...
Shizhen Tang, Aron S Buchman, Philip L De Jager, David A Bennett, Michael P Epstein, Jingjing Yang   +5 more
doaj   +1 more source

Genome-wide and transcriptome-wide association studies of mammographic density phenotypes reveal novel loci

Breast Cancer Research, 2022
Background Mammographic density (MD) phenotypes, including percent density (PMD), area of dense tissue (DA), and area of non-dense tissue (NDA), are associated with breast cancer risk. Twin studies suggest that MD phenotypes are highly heritable. However,
Hongjie Chen, Shaoqi Fan, Jennifer Stone, Deborah J. Thompson, Julie Douglas, Shuai Li, Christopher Scott, Manjeet K. Bolla, Qin Wang, Joe Dennis, Kyriaki Michailidou, Christopher Li, Ulrike Peters, John L. Hopper, Melissa C. Southey, Tu Nguyen-Dumont, Tuong L. Nguyen, Peter A. Fasching, Annika Behrens, Gemma Cadby, Rachel A. Murphy, Kristan Aronson, Anthony Howell, Susan Astley, Fergus Couch, Janet Olson, Roger L. Milne, Graham G. Giles, Christopher A. Haiman, Gertraud Maskarinec, Stacey Winham, Esther M. John, Allison Kurian, Heather Eliassen, Irene Andrulis, D. Gareth Evans, William G. Newman, Per Hall, Kamila Czene, Anthony Swerdlow, Michael Jones, Marina Pollan, Pablo Fernandez-Navarro, Daniel S. McConnell, Vessela N. Kristensen, NBCS Investigators, Joseph H. Rothstein, Pei Wang, Laurel A. Habel, Weiva Sieh, Alison M. Dunning, Paul D. P. Pharoah, Douglas F. Easton, Gretchen L. Gierach, Rulla M. Tamimi, Celine M. Vachon, Sara Lindström   +56 more
doaj   +1 more source

Alternative polyadenylation transcriptome-wide association study identifies APA-linked susceptibility genes in brain disorders

Nature Communications, 2023
Alternative polyadenylation (APA) plays an essential role in brain development; however, current transcriptome-wide association studies (TWAS) largely overlook APA in nominating susceptibility genes.
Ya Cui, F. Arnold, Fanglue Peng, Dan Wang, J. Li, S. Michels, E. Wagner, A. L. La Spada, Wei Li   +8 more
semanticscholar   +1 more source