Results 21 to 30 of about 8,166 (222)

Genome-Wide Association Study Identifies Candidate Genes for Body Size Traits in Wanyue Black Pigs [PDF]

Animals
This study aimed to elucidate the genetic basis of body-size-related traits in Wanyue Black pigs, including body length, chest circumference, forearm circumference, and hip circumference. Phenotypic data were collected from 139 four-month-old female pigs,
Haibo Ye, Wei Li, Fang Tian, Qianqian Wang, Zhonghua Ma, Jinyu Guan, Yueyun Ding, Xianrui Zheng, Zongjun Yin, Xiaodong Zhang   +9 more
doaj   +2 more sources

Monocyte inflammation and resilience to Alzheimer's disease: novel genetic risk genes identified by transcriptome-wide association study. [PDF]

Transl Psychiatry
Inflammation is a key driver of Alzheimer’s disease (AD) and may connect all known AD risk factors. Recently, AD resilience outcomes have been developed which have helped to uncover mechanisms that enable some individuals to withstand significant AD ...
Mustafa Y, Main LR, Mews M, Janve VA, Hohman TJ, Haines JL, Song YE, Griswold AJ, Pericak-Vance MA, Scott WK, Naj AC, Below JE, Dumitrescu L, Bush WS.   +13 more
europepmc   +2 more sources

Transcriptome-wide association study identifies genes associated with bladder cancer risk

Scientific Reports
Genome-wide association studies (GWAS) have detected several susceptibility variants for urinary bladder cancer, but how gene regulation affects disease development remains unclear.
Siting Li, Jiang Gui, Margaret R. Karagas, Michael N. Passarelli   +3 more
doaj   +2 more sources

Cell-type aware transcriptome-wide association study of mammographic density phenotypes

medRxiv
BackgroundMammographic density (MD) phenotypes are highly heritable and strongly associated with breast cancer risk. Genetic variants identified by genome-wide association studies (GWAS) explain only a small fraction of the heritability, and the ...
Sistig A, Rothstein JH, Zhu S, Head ST, Chang Y, Achacoso N, Alexeeff SE, Arasu V, Gadgil T, Gerstley LD, Margolies LR, Sakoda LC, Shen L, Smith Gueye CL, Villaseñor M, Westley M, MODE/BCAC Consortia, Bhattacharya A, Klein RJ, Habel LA, Song X, Wang P, Sieh W.   +22 more
europepmc   +2 more sources

Transcriptome-Wide Association Study of Metabolic Dysfunction-Associated Steatotic Liver Disease Identifies Relevant Gene Signatures

The Turkish Journal of Gastroenterology
Background/Aims: Metabolic dysfunction-associated steatotic liver disease (MASLD) is considered the most widespread chronic liver condition globally. Genome-wide association studies (GWAS) have pinpointed several genetic loci correlated to MASLD, yet the
Jianxiu Wang, Qian Gao
doaj   +2 more sources

Genomic Structural Equation Modeling Combined With Post-GWAS Analysis Identifies Two Risk Gene Loci and Functionally Sensitive Genes Associated With Cardiac Conduction Block. [PDF]

Genet Res (Camb)
Background Cardiac conduction disorders (CCDs) represent a broad spectrum of severe cardiovascular conditions associated with syncope and sudden cardiac death. Therefore, identification of reliable biomarkers is necessary to significantly improve the diagnostic accuracy and therapeutic outcomes of CCDs. This study analyzed GWAS summary datasets using a
Wang T, Miao X, Xia Y.
europepmc   +2 more sources

Genome- and Transcriptome-Wide Association Studies Identify Susceptibility Genes and Pathways for Periodontitis

Cells, 2022
Several genes associated with periodontitis have been identified through genome-wide association studies (GWAS); however, known genes only explain a minority of the estimated heritability.
Guirong Zhu, Xing Cui, Liwen Fan, Yongchu Pan, Lin Wang   +4 more
doaj   +1 more source

Multi-ancestry transcriptome-wide association analyses yield insights into tobacco use biology and drug repurposing [PDF]

, 2023
Most transcriptome-wide association studies (TWASs) so far focus on European ancestry and lack diversity. To overcome this limitation, we aggregated genome-wide association study (GWAS) summary statistics, whole-genome sequences and expression ...
Blangero, John, Cheng, Fang, Curran, Joanne E., Duggirala, Ravindranath, Jang, Seon-Kyeong, Khunsriraksakul, Chachrit, Peralta, Juan M., Quach, Bryan C., Wang, Xingyan, Weissenkampen, J. Dylan, Yang, Lina   +10 more
core   +8 more sources

High-Throughput Screen of NPQ in Sorghum Shows Highly Polygenic Architecture of Photoprotection. [PDF]

Plant Environ Interact
ABSTRACT Natural genetic variation in photosynthesis and photoprotection within crop germplasm represents an untapped resource for crop improvement. Sorghum bicolor (sorghum) is one of the world's most widely grown crops, yet the genetic basis of photoprotection in sorghum is not well understood.
Vath RL, Fernandes SB, Monier B, Głowacka K, Walter J, Lipka AE, Ferguson J, Bernacchi CJ, Pederson T, Kromdijk J.   +9 more
europepmc   +2 more sources

Transcriptome-wide association study of coronary artery disease identifies novel susceptibility genes. [PDF]

, 2022
The majority of risk loci identified by genome-wide association studies (GWAS) are in non-coding regions, hampering their functional interpretation. Instead, transcriptome-wide association studies (TWAS) identify gene-trait associations, which can be ...
Björkegren, Johan, Chen, Zhifen, Erdmann, Jeanette, Ermel, Raili, Gagneur, Julien, Güldener, Ulrich, Hao, Ke, Kessler, Thorsten, Koplev, Simon, Kovacic, Jason, Li, Ling, Li, Shuangyue, Lusis, Aldons, Ma, Angela, Pan, Calvin, Pang, Shichao, Ruusalepp, Arno, Schunkert, Heribert, Steiner, Andrea, Sukhavasi, Katyayani, von Scheidt, Moritz   +20 more
core   +1 more source