Advanced Functional Materials, EarlyView.In this work, melt electrowriting is used to fabricate a 3D printed scaffold design that generates engineered cardiac tissues with in‐plane contraction, mimicking natural myocardium. It is shown that these tissues display advanced maturation and functionality.
Olalla Iglesias‐García +23 more
wiley +1 more source
stMCDI: Masked Conditional Diffusion Model with Graph Neural Network for Spatial Transcriptomics Data Imputation [PDF]
arXivSpatially resolved transcriptomics represents a significant advancement in single-cell analysis by offering both gene expression data and their corresponding physical locations. However, this high degree of spatial resolution entails a drawback, as the resulting spatial transcriptomic data at the cellular level is notably plagued by a high incidence of
arxiv
Electric Pulse Regulated MXene Based Nanozymes for Integrative Bioelectricity Immuno‐Cancer Therapy
Advanced Functional Materials, EarlyView.MXenzyme‐mediated bioelectricity cancer therapy (MXenzyme‐BECT) enhances cancer cell death through irreversible depolarization, ion channel disruption, ROS generation, and immunogenic cell death. Computational simulations reveal the electrical mechanisms by which MXenzyme acts on single cells and support to predict treatment parameters. Next‐generation
Sanghee Lee +6 more
wiley +1 more source
IL‐12 and IL‐15 induce the expression of CXCR6 and CD49a on peripheral natural killer cells
Immunity, Inflammation and Disease, 2018 Introduction Murine hepatic NK cells exhibit adaptive features, with liver‐specific adhesion molecules CXCR6 and CD49a acting as surface markers. Methods We investigated human liver‐resident CXCR6+ and CD49a+ NK cells using RNA sequencing, flow cytometry,
Theresa Hydes +9 more
doaj +1 more source
An Enrichment Method for Obtaining Biologically Significant Genes from Statistically Significant Differentially Expressed Genes in Comparative Transcriptomics [PDF]
arXiv, 2017 Cells coordinate adjustments in genome expression to accommodate changes in their environment. A drug in culture media for in vitro preclinical testing sometimes cause drastic regime shifting of genome expression system depending on the concentrations; e.g.
arxiv
Transcriptome of a mouse kidney cortical collecting duct cell line: Effects of aldosterone and vasopressin [PDF]
, 2001 Maya Robert-Nicoud +12 more
openalex +1 more source
Advanced Healthcare Materials, EarlyView.Minimal residual disease (MRD) leads to cancer relapse and poor survival in ovarian cancer. The lack of representative 3D models limits therapy development. The microfluidics‐based high throughput 3D microtumor platform described here generates clinically‐relevant MRD models. The 3D microtumors recapitulate the molecular signatures of MRD from patients.
Xingyun Yang +14 more
wiley +1 more source
Trustworthy Enhanced Multi-view Multi-modal Alzheimer's Disease Prediction with Brain-wide Imaging Transcriptomics Data [PDF]
arXivBrain transcriptomics provides insights into the molecular mechanisms by which the brain coordinates its functions and processes. However, existing multimodal methods for predicting Alzheimer's disease (AD) primarily rely on imaging and sometimes genetic data, often neglecting the transcriptomic basis of brain.
arxiv
The contribution of 700,000 ORF sequence tags to the definition of the human transcriptome [PDF]
, 2001 Anamaria A. Camargo +99 more
openalex +1 more source