Results 101 to 110 of about 474,674 (279)

Expanding Chemical Space of Nucleic Acid Nanoparticles for Tunable Antiviral‐Like Immunomodulatory Responses and Potent Adjuvant Activity

Advanced Functional Materials, EarlyView.
We introduce a nucleic acid nanoparticle (NANP) platform designed to be rrecognized by the human innate immune system in a regulated manner. By changing chemical composition while maintaining constant architectural parameters, we identify key determinants of immunorecognition enabling the rational design of NANPs with tunable immune activation profiles
Martin Panigaj, Hannah S. Newton, Jian Wang, Laxmi Pandey, Yelixza I. Avilla, Phong Nguyen, Morgan Chandler, Justin Halman, Yasmine Radwan, Stephanie Smith, Elijah Edmondson, Simone Difilippantonio, Chelsea Sanders, Bao Tran, Yongmei Zhao, Shaojun Xie, Edward Cedrone, Barry W. Neun, Meni Wanunu, Nikolay V. Dokholyan, Marina A. Dobrovolskaia, Kirill A. Afonin   +21 more
wiley   +1 more source

Quantification of DNA probes on nylon microarrays using T4 polynucleotide kinase labeling

BioTechniques, 2003
M. El Atifi, I. Dupré, B. Rostaing, A.L. Benabid, F. Berger   +4 more
doaj   +1 more source

A Smart Bio‐Battery Facilitates Diabetic Bone Defect Repair Via Inducing Macrophage Reprogramming and Synergistically Modulating Bone Remodeling Coupling

Advanced Functional Materials, EarlyView.
This research presents a novel implantable bio‐battery, GF‐OsG, tailored for diabetic bone repair. GF‐OsG generates microcurrents in high‐glucose conditions to enhance vascularization, shift macrophages to the M2 phenotype, and regulate immune responses.
Nanning Lv, Haifu Sun, Wenxiang Tang, Yonggang Li, Zhonglai Qian, Lihui Hong, Chong Chen, Hongye Li, Jiaxiang Bai, Yusen Qiao, Mingming Liu   +10 more
wiley   +1 more source

Comparative immune-relevant transcriptome reveals the evolutionary basis of complex traits

, 2022
Wenjing Yang, Jian Yu, Yuelin Yao, Siqian Chen, Bingru Zhao, Shuli Liu, Lei Zhou, Lingzhao Fang, Jianfeng Liu   +8 more
openalex   +1 more source

A Single‐Metal‐Doped Nanoplatform for Ferroptosis‐Driven cGAS‐STING Pathway Activation in Hepatocellular Carcinoma Immunotherapy

Advanced Functional Materials, EarlyView.
The cGAS‐STING pathway boosts HCC antitumor immunity but lacks specific activation. Nanoplatform ZMRPF induces HCC ferroptosis via lipid ROS, releasing mtDNA. It synergizes with ZMRPF‐released Mn2⁺ to activate cGAS‐STING, amplifies antigen‐presenting cell activity, reverses HCC immunosuppression, and enables robust systemic antitumor immunity ...
Yuchen Zhang, Shuang Feng, Jie Luo, Kaige Xu, Junfeng Guo, Xingyue Zhang, Mengxue Yuan, Qiang Luo, Yu Huang, Chaoqiang Fan, Kibret Mequanint, Donghui Zhu, Malcolm Xing, Shiming Yang   +13 more
wiley   +1 more source

Genome-wide characteristics and potential functions of circular RNAs from the embryo muscle development in Chengkou mountain chicken

Frontiers in Veterinary Science
The Chengkou mountain chicken, a native Chinese poultry breed, holds significant importance in the country’s poultry sector due to its delectable meat and robust stress tolerance.
Yang Zhang, Haiwei Wang, Xingqi Li, Chaowu Yang, Chunlin Yu, Zhifu Cui, Anfang Liu, Qigui Wang, Lingbin Liu   +8 more
doaj   +1 more source

Transcriptome sequencing across a prostate cancer cohort identifies PCAT-1, an unannotated lincRNA implicated in disease progression

, 2011
John R. Prensner, Matthew K. Iyer, O. Alejandro Balbin, Saravana M. Dhanasekaran, Qi Cao, J. Chad Brenner, Bharathi Laxman, Irfan A. Asangani, Catherine S. Grasso, Hal D. Kominsky, Xuhong Cao, Xiaojun Jing, Xiaoju Wang, Javed Siddiqui, John T. Wei, Daniel Robinson, Hari Iyer, Nallasivam Palanisamy, Christopher A. Maher, Arul M. Chinnaiyan   +19 more
openalex   +2 more sources

Proteins, Processing, and Properties of Adhesive Fluid Condensates Purified from Mussels

Advanced Functional Materials, EarlyView.
Mussels exhibit an unmatched proficiency for adhering to wet surfaces in salty environments—a remarkable ability that could inspire new biomedical and technical glues. The fluid protein condensates used to form the underwater mussel glue are extracted, reconstituted and characterized with advanced spectroscopy and nanomechanical analysis, revealing ...
Mathieu D. Rivard, Max Renner‐Rao, Nahid Hassanpour, Franziska Jehle, Chang‐Sheng Wang, Duy Anh Pham, Daniel J. Jackson, Xavier Banquy, Matthew J. Harrington   +8 more
wiley   +1 more source

Glioblastoma with high O6-methyl-guanine DNA methyltransferase expression are more immunologically active than tumors with low MGMT expression

Frontiers in Immunology
BackgroundGlioblastoma (GBM) is a highly lethal brain tumor. The effectiveness of temozolomide (TMZ) treatment in GBM is linked to the methylation status of O6-methyl-guanine DNA methyltransferase (MGMT) promoter. Patients with unmethylated MGMT promoter
Yoshihiro Kushihara, Yoshihiro Kushihara, Shota Tanaka, Yukari Kobayashi, Koji Nagaoka, Miyu Kikuchi, Takahide Nejo, Erika Yamazawa, Erika Yamazawa, Shohei Nambu, Kazuha Kugasawa, Hirokazu Takami, Shunsaku Takayanagi, Nobuhito Saito, Kazuhiro Kakimi, Kazuhiro Kakimi   +15 more
doaj   +1 more source

Global Transcriptome Analysis ofShewanella oneidensisMR-1 Exposed to Different Terminal Electron Acceptors

, 2005
A. S. Beliaev, Dawn M. Klingeman, J. A. Klappenbach, Liyou Wu, Margaret F. Romine, James M. Tiedje, Kenneth H. Nealson, J. K. Fredrickson, Jizhong Zhou   +8 more
openalex   +1 more source