Results 101 to 110 of about 963,153 (378)

Spatial Transcriptomic Technologies

Cells, 2023
Spatial transcriptomic technologies enable measurement of expression levels of genes systematically throughout tissue space, deepening our understanding of cellular organizations and interactions within tissues as well as illuminating biological insights in neuroscience, developmental biology and a range of diseases, including cancer.
Tsai-Ying Chen, Li You, Jose Angelito U. Hardillo, Miao-Ping Chien   +3 more
openaire   +3 more sources

A seven-gene cluster in Ruminiclostridium cellulolyticum is essential for signalization, uptake and catabolism of the degradation products of cellulose hydrolysis

Biotechnology for Biofuels, 2017
Background Like a number of anaerobic and cellulolytic Gram-positive bacteria, the model microorganism Ruminiclostridium cellulolyticum produces extracellular multi-enzymatic complexes called cellulosomes, which efficiently degrade the crystalline ...
Aurélie Fosses, Maria Maté, Nathalie Franche, Nian Liu, Yann Denis, Romain Borne, Pascale de Philip, Henri-Pierre Fierobe, Stéphanie Perret   +8 more
doaj   +1 more source

Single-cell transcriptome profiling reveals neutrophil heterogeneity in homeostasis and infection

Nature Immunology, 2020
The full neutrophil heterogeneity and differentiation landscape remains incompletely characterized. Here, we profiled >25,000 differentiating and mature mouse neutrophils using single-cell RNA sequencing to provide a comprehensive transcriptional ...
Xuemei Xie, Q. Shi, Peng Wu, Xiaoyu Zhang, Hiroto Kambara, Jiayu Su, Hongbo Yu, Shin-Young Park, Rongxia Guo, Qian Ren, Sudong Zhang, Yuanfu Xu, L. Silberstein, T. Cheng, F. Ma, Cheng Li, Hongbo R. Luo   +16 more
semanticscholar   +1 more source

Single-cell transcriptome and translatome dual-omics reveals potential mechanisms of human oocyte maturation

Nature Communications, 2022
The combined use of transcriptome and translatome as indicators of gene expression profiles is usually more accurate than the use of transcriptomes alone, especially in cell types governed by translational regulation, such as mammalian oocytes.
Wenqi Hu, H. Zeng, Yanan Shi, Chuanchuan Zhou, Jiana Huang, L. Jia, Siqi Xu, Xiaoyu Feng, Yanyan Zeng, Tuanlin Xiong, Wenze Huang, P. Sun, Yajie Chang, Tingting Li, C. Fang, Keliang Wu, Ling-bo Cai, Wuhua Ni, Yan Li, Zhiyong Yang, Q. Zhang, R. Chian, Zijiang Chen, Xiaoyan Liang, Kehkooi Kee   +24 more
semanticscholar   +1 more source

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

Molecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani, Gilgi Friedlander, Gili Perry, Nora Balint‐Lahat, Shlomit Gilad, Dana Morzaev‐Sulzbach, Anjana Shenoy, Noa Bossel Ben‐Moshe, Anya Pavlovsky, Rinat Bernstein‐Molho, Eytan Domany, Iris Barshack, Tamar Geiger, Bella Kaufman, Einav Nili Gal‐Yam   +14 more
wiley   +1 more source

Fishing Into the MicroRNA Transcriptome [PDF]

Frontiers in Genetics, 2018
In the last decade, several studies have been focused on revealing the microRNA (miRNA) repertoire and determining their functions in farm animals such as poultry, pigs, cattle, and fish. These small non-protein coding RNA molecules (18-25 nucleotides) are capable of controlling gene expression by binding to messenger RNA (mRNA) targets, thus ...
Herkenhoff, Marcos E., Oliveira, Arthur C., Nachtigall, Pedro G., Costa, Juliana M., Campos, Vinicius F., Hilsdorf, Alexandre W. S., Pinhal, Danillo   +6 more
openaire   +5 more sources

Transcriptome and genome sequencing uncovers functional variation in humans

Nature, 2013
Genome sequencing projects are discovering millions of genetic variants in humans, and interpretation of their functional effects is essential for understanding the genetic basis of variation in human traits.
T. Lappalainen, M. Sammeth, M. Friedländer, P. ’. ’t Hoen, Jean Monlong, M. Rivas, Mar Gonzàlez-Porta, N. Kurbatova, Thasso Griebel, Pedro G. Ferreira, Matthias Barann, T. Wieland, Liliana Greger, M. van Iterson, J. Almlöf, Paolo Ribeca, I. Pulyakhina, Daniela Esser, T. Giger, Andrew Tikhonov, M. Sultan, Gabrielle Bertier, D. MacArthur, M. Lek, Esther Lizano, H. Buermans, Ismael Padioleau, T. Schwarzmayr, O. Karlberg, H. Ongen, H. Kilpinen, S. Beltran, M. Gut, Katja Kahlem, V. Amstislavskiy, O. Stegle, M. Pirinen, S. Montgomery, P. Donnelly, M. McCarthy, Paul Flicek, T. Strom, H. Lehrach, S. Schreiber, R. Sudbrak, Á. Carracedo, S. Antonarakis, R. Häsler, A. Syvänen, G. van Ommen, A. Brazma, T. Meitinger, P. Rosenstiel, R. Guigó, I. Gut, X. Estivill, E. Dermitzakis   +56 more
semanticscholar   +1 more source

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes   +17 more
wiley   +1 more source

Inside the granulosa transcriptome

Gynecological Endocrinology, 2016
The somatic component of follicular structure is a mixture of different cell types, represented by Granulosa cells (GCs) that are the paracrine regulators of the oocyte growth. GCs finely support this process by a continuous bidirectional talk with oocyte, which ensure oocyte quality and competence.
D'AURORA, MARCO, SPERDUTI, SAMANTHA, Di Emidio, Giovanna, STUPPIA, Liborio, Artini, Paolo Giovanni, GATTA, Valentina   +5 more
openaire   +3 more sources

Muscle transcriptome analysis reveals molecular pathways and biomarkers involved in extreme ultimate pH and meat defect occurrence in chicken

Scientific Reports, 2017
The processing ability and sensory quality of chicken breast meat are highly related to its ultimate pH (pHu), which is mainly determined by the amount of glycogen in the muscle at death.
Stéphane Beauclercq, Christelle Hennequet-Antier, Christophe Praud, Estelle Godet, Anne Collin, Sophie Tesseraud, Sonia Métayer-Coustard, Marie Bourin, Marco Moroldo, Frédéric Martins, Sandrine Lagarrigue, Elisabeth Le Bihan-Duval, Cécile Berri   +12 more
doaj   +1 more source