Results 111 to 120 of about 398,969 (379)

Metabolic-imaging of human glioblastoma live tumors: A new precision-medicine approach to predict tumor treatment response early

Frontiers in Oncology, 2022
BackgroundGlioblastoma (GB) is the most severe form of brain cancer, with a 12-15 month median survival. Surgical resection, temozolomide (TMZ) treatment, and radiotherapy remain the primary therapeutic options for GB, and no new therapies have been ...
Mariangela Morelli, Francesca Lessi, Serena Barachini, Serena Barachini, Romano Liotti, Romano Liotti, Nicola Montemurro, Paolo Perrini, Orazio Santo Santonocito, Carlo Gambacciani, Matija Snuderl, Francesco Pieri, Filippo Aquila, Azzurra Farnesi, Antonio Giuseppe Naccarato, Paolo Viacava, Francesco Cardarelli, Gianmarco Ferri, Gianmarco Ferri, Paul Mulholland, Diego Ottaviani, Fabiola Paiar, Gaetano Liberti, Francesco Pasqualetti, Francesco Pasqualetti, Michele Menicagli, Paolo Aretini, Giovanni Signore, Sara Franceschi, Chiara Maria Mazzanti   +29 more
doaj   +1 more source

From lactation to malignancy: A comparison between healthy and cancerous breast gland at single‐cell resolution reveals new issues for tumorigenesis

FEBS Letters, EarlyView.
Single‐cell RNA sequencing reveals an opposite role of SLPI in basal tumors based on metastatic spread, along with shared activation of specific regulons in cancer cells and mature luminal lactocytes, as well as downregulation of MALAT1 and NEAT1 in the latter.
Pietro Ancona, Carlo M. Bergamini, Carlo Ferrari, Stefano Volinia, Nicoletta Bianchi   +4 more
wiley   +1 more source

Inside the granulosa transcriptome

Gynecological Endocrinology, 2016
The somatic component of follicular structure is a mixture of different cell types, represented by Granulosa cells (GCs) that are the paracrine regulators of the oocyte growth. GCs finely support this process by a continuous bidirectional talk with oocyte, which ensure oocyte quality and competence.
D'AURORA, MARCO, SPERDUTI, SAMANTHA, Di Emidio, Giovanna, STUPPIA, Liborio, Artini, Paolo Giovanni, GATTA, Valentina   +5 more
openaire   +3 more sources

The MarR-Type Repressor MhqR Confers Quinone and Antimicrobial Resistance in Staphylococcus aureus [PDF]

, 2019
Aims: Quinone compounds are electron carriers and have antimicrobial and toxic properties due to their mode of actions as electrophiles and oxidants.
Fritsch, Verena Nadin, Loi, Vu Van, Busche, Tobias, Sommer, Anna, Tedin, Karsten, Nürnberg, Dennis J., Kalinowski, Jörn, Bernhardt, Jörg, Fulde, Marcus, Antelmann, Haike   +9 more
core   +1 more source

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

Molecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source

Genomes and Transcriptomes of Duckweeds [PDF]

Frontiers in Chemistry, 2018
Duckweeds (Lemnaceae family) are the smallest flowering plants that adapt to the aquatic environment. They are regarded as the promising sustainable feedstock with the characteristics of high starch storage, fast propagation, and global distribution.
Wenqin Wang, Yongrui Wu, Yong Zhou, Changsheng Li, Dong An   +4 more
openaire   +4 more sources

HIV-Tocky system to visualize proviral expression dynamics

Communications Biology
Determinants of HIV-1 latency establishment are yet to be elucidated. HIV reservoir comprises a rare fraction of infected cells that can survive host and virus-mediated killing.
Omnia Reda, Kazuaki Monde, Kenji Sugata, Akhinur Rahman, Wajihah Sakhor, Samiul Alam Rajib, Sharmin Nahar Sithi, Benjy Jek Yang Tan, Koki Niimura, Chihiro Motozono, Kenji Maeda, Masahiro Ono, Hiroaki Takeuchi, Yorifumi Satou   +13 more
doaj   +1 more source

Probing Plasmodium falciparum sexual commitment at the single-cell level [PDF]

, 2018
Background: Malaria parasites go through major transitions during their complex life cycle, yet the underlying differentiation pathways remain obscure.
Birren, Bruce W., Brancucci, Nicolas M.B., De Niz, Mariana, Marti, Matthias, Neafsey, Daniel E., Ravel, Deepali, Sollelis, Lauriane, Straub, Timothy J., Voss, Till S.   +8 more
core   +4 more sources

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

Evolution: The Plastic Transcriptome [PDF]

Current Biology, 2006
Studies across a wide range of species point to a surprising degree of plasticity in the transcriptional states that organisms can adopt, suggesting that organisms often respond to environmental challenges through wholesale reprogramming of their gene expression.
openaire   +4 more sources