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Microneedles for transdermal drug delivery
Advanced Drug Delivery Reviews, 2004The success of transdermal drug delivery has been severely limited by the inability of most drugs to enter the skin at therapeutically useful rates. Recently, the use of micron-scale needles in increasing skin permeability has been proposed and shown to dramatically increase transdermal delivery, especially for macromolecules.
Mark R Prausnitz
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Annual Review of Medicine, 1988
Transdermal drug delivery involves the continuous administration of therapeutic molecules through the skin. It has the advantage of maintaining constant drug plasma levels and improving patient compliance. Compared to the oral route, losses in bioavailability due to first-pass liver metabolism are reduced. This paper describes the theory of transdermal
L, Brown, R, Langer
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Transdermal drug delivery involves the continuous administration of therapeutic molecules through the skin. It has the advantage of maintaining constant drug plasma levels and improving patient compliance. Compared to the oral route, losses in bioavailability due to first-pass liver metabolism are reduced. This paper describes the theory of transdermal
L, Brown, R, Langer
+5 more sources
Transdermal drug delivery devices
Clinics in Dermatology, 1989Abstract The concept of transdermal delivery is not new, but until recently, its therapeutic application was restricted to creams and ointments which are messy and difficult to apply uniformly to ensure reproducible dosing. In the late 1970s, technology was developed that permitted the construction of multicomponent devices embodying the ability to ...
P W, Ledger, K C, Nichols
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Proniosomes in Transdermal Drug Delivery
Current Pharmaceutical Design, 2015Proniosomes are liquid crystalline-compact niosomal hybrid that can be hydrated to form niosomal dispersion instantly before use. It is a promising drug carrier with better physical and chemical stability than niosomes. Proniosomes have the potential to be scaled up for industrial purposes.
Yahya, Rahimpour +2 more
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Sonophoresis in transdermal drug deliverys
Ultrasonics, 2014Transdermal drug delivery (TDD) has several significant advantages compared to oral drug delivery, including elimination of pain and sustained drug release. However, the use of TDD is limited by low skin permeability due to the stratum corneum (SC), the outermost layer of the skin.
Donghee, Park +3 more
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Ultrasound and transdermal drug delivery
Drug Discovery Today, 2004Transdermal drug delivery offers an attractive alternative to the conventional drug delivery methods of oral administration and injection. However, the stratum corneum acts as a barrier that limits the penetration of substances through the skin. Application of ultrasound to the skin increases its permeability (sonophoresis) and enables the delivery of ...
Ilana, Lavon, Joseph, Kost
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2021
The ADME Encyclopedia will cover pharmacokinetic processes (Absorption, Distribution, Metabolism and Excretion processes) and their relationship with the design of pharmaceutical carriers and the success of drug therapies. It covers both basic and advanced knowledge in the field, serving as introductory material for students of biomedical careers and ...
Nacucchio, Marcelo Carlos +1 more
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The ADME Encyclopedia will cover pharmacokinetic processes (Absorption, Distribution, Metabolism and Excretion processes) and their relationship with the design of pharmaceutical carriers and the success of drug therapies. It covers both basic and advanced knowledge in the field, serving as introductory material for students of biomedical careers and ...
Nacucchio, Marcelo Carlos +1 more
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Optimisation of Drug Delivery: 4. Transdermal Drug Delivery
The Australian Journal of Hospital Pharmacy, 1997This article reviews the current status and possible future directions for transdermal drug delivery. Skin penetration is briefly discussed and chemical and physical enhancer methods to increase skin penetration are outlined. Design considerations for transdermal drug delivery systems and products available in Australia are reviewed.
Heather AE Benson, Richard J Prankerd
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Cutaneous Metabolism in Transdermal Drug Delivery
Current Drug Metabolism, 2009The skin is the major interface between the body and the environment. The cutaneous metabolic activity has been identified and widely studied in recent years. It is clear that active enzymes in viable skin tissues have a capacity for bio-transforming topically applied compounds, with a consequence of an altered pharmacological effect.
Zhang, Qian +3 more
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