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Iontophoresis-Mediated Transdermal Permeation of Peptide Dendrimers across Human Epidermis
Skin Pharmacology and Physiology, 2013<b><i>Purpose of the Study:</i></b> The overall aim of the present work was to elucidate the effects of iontophoresis on assisting permeation/deposition of peptide dendrimers across/within human skin. <b><i>Procedures:</i></b> A series of peptide dendrimers containing arginine and histidine as terminal ...
Mutalik, S. +4 more
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Transdermal permeation-enhancing activities of some inorganic anions
Archives of Pharmacal Research, 1995Effects of sodium salts of various monovalent inorganic anions on transdermal permeation of salicylic acid were investigated. In in-vitro experiment using a Franz-type diffusion cell and excised mouse skin, the permeation-enhancing activities of the sodium salts of inorganic anions were roughly proportional to lyotropic Hofmeister swelling abilities of
Young Il Ko, Sung Su Kim, Suk Kyu Han
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Transdermal Permeation Enhancing Potentials of Natural Products
Drug Delivery Letters: Skin is a formidable natural barrier that represents the most important obstacle in clinical practices pertaining to the cutaneous administration of exogenous molecules/drugs. As transdermal therapy systems offer a more dependable way of distributing drugs by way of permeation enhancers, it is vital to use ...
Richa Kankane +2 more
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Solubility and in vitro transdermal permeation of nifedipine
International Journal of Pharmaceutics, 1997Abstract The solubilities of a hydrophobic drug, nifedipine, in a diverse panel of solvent and cosolvent systems were determined experimentally at room temperature. The observed solubilities were examined for deviations from regular solution solubilities as calculated by the Hildebrand and Scott Equation.
Emilio Squillante +2 more
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An Electrochemical Transdermal Patch for Permeation Enhancement
2017A novel electrochemical patch is described that works by the hydrolysis of water in a hydrogel between two suitable electrodes that produces a strongly enhanced drug flux through the skin. This non-iontophoretic mechanism requires only a short voltage application (60 s) yet produces enhanced skin permeation over up to 5 h.
Geoffrey Lee +3 more
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Applications of ultrasonic skin permeation in transdermal drug delivery
Expert Opinion on Drug Delivery, 2008Transdermal ultrasound-mediated drug delivery has been studied as a method for needle-less, non-invasive drug administration. Potential obstacles include the stratum corneum, which is not sufficiently passively permeable to allow effective transfer of many medications into the bloodstream without active methods.
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Transdermal Permeation Behavior of 5-FU using Microneedle
Journal of Korean Pharmaceutical Sciences, 20085-Fluorouracil (5-FU) is an antimetabolic of the pyrimidine derivatives that is used in chemotherapy for the treatment of several types of cancer. 5-FU have poor oral absorption and short biological half-time and strong side effects. Microneedle introduced to find a solution of problems.
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Improvement of transdermal permeation of captopril by iontophoresis.
Acta pharmacologica Sinica, 2001The feasibility of iontophoresis on the transdermal delivery of captopril was studied.Iontophoresis was employed for enhancing transdermal transport of captopril through rat skin in vitro and in vivo.It was demonstrated that the iontophoresis-induced flux of captopril was affected by various factors such as pH, ionic concentration, and the ...
H, Wang, H M, Hou
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Comparison of Ionic Liquids and Chemical Permeation Enhancers for Transdermal Drug Delivery
Advanced Functional Materials, 2020Qin M Qi +2 more
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