Results 191 to 200 of about 93,495 (232)
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Homoharringtonine is a transdermal granular permeation enhancer
Biochemical and Biophysical Research Communications, 2022Although modulation of claudin-1-based tight junction (TJ) in stratum granulosum is an option for transdermal absorption of drugs, granular permeation enhancers have never been developed. We previously found that homoharringtonine (HHT), a natural alkanoid, weakened intestinal epithelial barrier with changing expression and cellular localization of TJ ...
Akihiro, Watari +6 more
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In Vitro Studies on Transdermal Permeation of Butorphanol
Drug Development and Industrial Pharmacy, 2007The influence of the donor vehicles pH and the addition of laurocapram or transkarbam 12 as permeation enhancers on the transdermal permeation of butorphanol through human skin were examined with the aim of finding out about its possible use in the transdermal delivery system.
Michal, Svozil +3 more
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Physicochemical aspects of transdermal permeation
Journal of Controlled Release, 1987Abstract The nature and state of lipids are often important regulators in many membrane functions and properties. Current studies probe the physicochemical aspects of the enhanced permeabilities of lipophilic solutes through hairless mouse stratum corneum.
K. Knutson +3 more
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Amino acid derivatives as transdermal permeation enhancers
Journal of Controlled Release, 2013Transdermal permeation enhancers are compounds that temporarily decrease skin barrier properties to promote drug flux. In this study, we investigated enhancers with amino acids (proline, sarcosine, alanine, β-alanine, and glycine) attached to hydrophobic chain(s) via a biodegradable ester link.
Barbora, Janůšová +11 more
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Transdermal permeation of neutral molecules by skin electroporation
Journal of Controlled Release, 1998Electroporation of skin has recently been shown to enhance transport of charged molecules across skin by up to four orders of magnitude. This study demonstrates that high-voltage pulses can also increase transdermal permeation of two neutral model solutes, i.e. mannitol and water, up to 100-fold.
Vanbever, Rita +2 more
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Transdermal self-permeation enhancement of ibuprofen
Journal of Controlled Release, 2004The objective of this study was to prepare saturated solutions of ibuprofen, of different concentrations, and to investigate their effect on permeation of ibuprofen across rat epidermis. Ibuprofen saturated solutions were prepared using 0.1, 0.2, 0.3 and 0.4 M disodium hydrogen phosphate solution (DHP).
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Transdermal Permeation Modulation by Cyclodextrins: A Mechanistic Study
Pharmaceutical Development and Technology, 1998The purpose of this study was to investigate permeation modulation by beta- and 2-hydroxypropyl-beta-cyclodextrins (beta-CD and HP-beta-CD, respectively) alone and complexed with penetration enhancers for the test drugs 5-fluorouracil and estradiol through human skin, and to probe the value of the CDs in a barrier cream against toluene exposure ...
A C, Williams, S R, Shatri, B W, Barry
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Transkarbams with terminal branching as transdermal permeation enhancers
Bioorganic & Medicinal Chemistry Letters, 2008Transkarbams (T) represent novel group of highly active, non-toxic transdermal permeation enhancers. This study was focused on the influence of small symmetrical terminal branching on their enhancing activity. Series of T with terminal methyl or ethyl branching was prepared and their permeation-enhancing activity was compared to that of their linear ...
Jana, Klimentová +5 more
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Alaptide as Transdermal Permeation Modifier
2015Based on the fact that alaptide is able to influence the creation and function of keratinocytes, it was supposed that alaptide could be used as a transdermal permeation modifier. Various APIs (bases, acids, salts, neutral molecules, small molecules, steroid-like molecules) were tested on their transdermal permeation in the mixture with micronized and ...
Josef Jampílek, Jiří Dohnal
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An investigation of the effect of surfactants on transdermal permeation
1994The aim of this study was to investigate the direct effects of surfactants on the stratum corneum, and thus propose mechanisms of action for these compounds as penetration enhancers. The main methods used in the study were: determination of the permeability of neonatal rat stratum corneum to propan-2-ol; differential scanning calorimetry (DSC); Fourier
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