Results 191 to 200 of about 17,365 (234)

Homoharringtonine is a transdermal granular permeation enhancer

Biochemical and Biophysical Research Communications, 2022
Although modulation of claudin-1-based tight junction (TJ) in stratum granulosum is an option for transdermal absorption of drugs, granular permeation enhancers have never been developed. We previously found that homoharringtonine (HHT), a natural alkanoid, weakened intestinal epithelial barrier with changing expression and cellular localization of TJ ...
Akihiro, Watari, Kana, Fujiwara, Kiyohito, Yagi, Keisuke, Tachibana, Takeshi, Katsurada, Akira, Myoui, Masuo, Kondoh   +6 more
openaire   +2 more sources

Physicochemical aspects of transdermal permeation

Journal of Controlled Release, 1987
Abstract The nature and state of lipids are often important regulators in many membrane functions and properties. Current studies probe the physicochemical aspects of the enhanced permeabilities of lipophilic solutes through hairless mouse stratum corneum.
K. Knutson, S.L. Krill, W.J. Lambert, W.I. Higuchi   +3 more
openaire   +1 more source

Amino acid derivatives as transdermal permeation enhancers

Journal of Controlled Release, 2013
Transdermal permeation enhancers are compounds that temporarily decrease skin barrier properties to promote drug flux. In this study, we investigated enhancers with amino acids (proline, sarcosine, alanine, β-alanine, and glycine) attached to hydrophobic chain(s) via a biodegradable ester link.
Barbora, Janůšová, Barbora, Skolová, Katarína, Tükörová, Lea, Wojnarová, Tomáš, Simůnek, Přemysl, Mladěnka, Tomáš, Filipský, Michal, Ríha, Jaroslav, Roh, Karel, Palát, Alexandr, Hrabálek, Kateřina, Vávrová   +11 more
openaire   +2 more sources

Amphiphilic Transdermal Permeation Enhancers: Structure-Activity Relationships

Current Medicinal Chemistry, 2005
Transdermal drug delivery offers numerous advantages over conventional routes of administration; however, poor permeation of most drugs across the skin barrier constitutes a serious limitation of this methodology. One of the approaches used to enlarge the number of transdermally-applicable drugs uses permeation enhancers.
K, Vávrová, J, Zbytovská, A, Hrabálek   +2 more
openaire   +2 more sources

Alaptide as Transdermal Permeation Modifier

2015
Based on the fact that alaptide is able to influence the creation and function of keratinocytes, it was supposed that alaptide could be used as a transdermal permeation modifier. Various APIs (bases, acids, salts, neutral molecules, small molecules, steroid-like molecules) were tested on their transdermal permeation in the mixture with micronized and ...
Josef Jampílek, Jiří Dohnal
openaire   +1 more source

In Vitro Studies on Transdermal Permeation of Butorphanol

Drug Development and Industrial Pharmacy, 2007
The influence of the donor vehicles pH and the addition of laurocapram or transkarbam 12 as permeation enhancers on the transdermal permeation of butorphanol through human skin were examined with the aim of finding out about its possible use in the transdermal delivery system.
Michal, Svozil, Pavel, Dolezal, Alexander, Hrabálek, Pavel, Mericka   +3 more
openaire   +2 more sources

Transdermal permeation of neutral molecules by skin electroporation

Journal of Controlled Release, 1998
Electroporation of skin has recently been shown to enhance transport of charged molecules across skin by up to four orders of magnitude. This study demonstrates that high-voltage pulses can also increase transdermal permeation of two neutral model solutes, i.e. mannitol and water, up to 100-fold.
R, Vanbever, M A, Leroy, V, Préat
openaire   +2 more sources

Transdermal self-permeation enhancement of ibuprofen

Journal of Controlled Release, 2004
The objective of this study was to prepare saturated solutions of ibuprofen, of different concentrations, and to investigate their effect on permeation of ibuprofen across rat epidermis. Ibuprofen saturated solutions were prepared using 0.1, 0.2, 0.3 and 0.4 M disodium hydrogen phosphate solution (DHP).
openaire   +2 more sources

Transdermal delivery of naloxone: ex vivo permeation studies

International Journal of Pharmaceutics, 1999
The purpose of this investigation was to study the feasibility of transdermal drug delivery of the potent opioid antagonist naloxone. The pharmacokinetic profile of naloxone makes it a suitable candidate for transdermal delivery. Ex vivo permeation of naloxone through excised rat skin was studied using a diffusion cell.
J, Jaiswal, R, Poduri, R, Panchagnula
openaire   +2 more sources

Transdermal Permeation Modulation by Cyclodextrins: A Mechanistic Study

Pharmaceutical Development and Technology, 1998
The purpose of this study was to investigate permeation modulation by beta- and 2-hydroxypropyl-beta-cyclodextrins (beta-CD and HP-beta-CD, respectively) alone and complexed with penetration enhancers for the test drugs 5-fluorouracil and estradiol through human skin, and to probe the value of the CDs in a barrier cream against toluene exposure ...
A C, Williams, S R, Shatri, B W, Barry
openaire   +2 more sources