Results 171 to 180 of about 7,154 (195)
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Transdermal delivery of naloxone: ex vivo permeation studies
International Journal of Pharmaceutics, 1999The purpose of this investigation was to study the feasibility of transdermal drug delivery of the potent opioid antagonist naloxone. The pharmacokinetic profile of naloxone makes it a suitable candidate for transdermal delivery. Ex vivo permeation of naloxone through excised rat skin was studied using a diffusion cell.
J, Jaiswal, R, Poduri, R, Panchagnula
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Sucrose Esters as Transdermal Permeation Enhancers
2015Surfactants are widely used excipients in topical formulations, not only for their solubilizing and emulsifying properties but also for their well-known capacity to enhance drug permeation. Although nonionic surfactants are frequently chosen because of their mild effect on the skin, they share a low efficacy as permeation enhancers.
María Guadalupe Nava-Arzaluz +2 more
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Design of improved permeation enhancers for transdermal drug delivery
Journal of Pharmaceutical Sciences, 2009One promising way to breach the skin's natural barrier to drugs is by the application of chemicals called penetration enhancers. However, identifying potential enhancers is difficult and time consuming. We have developed a virtual screening algorithm for generating potential chemical penetration enhancers (CPEs) by integrating nonlinear, theory-based ...
Srinivas S, Godavarthy +6 more
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An Electrochemical Transdermal Patch for Permeation Enhancement
2017A novel electrochemical patch is described that works by the hydrolysis of water in a hydrogel between two suitable electrodes that produces a strongly enhanced drug flux through the skin. This non-iontophoretic mechanism requires only a short voltage application (60 s) yet produces enhanced skin permeation over up to 5 h.
Geoffrey Lee +3 more
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Transdermal Absorption of Radioprotectors Using Permeation-Enhancing Vehicles
Radiation Research, 1990Radioprotectors are not currently used clinically due to concerns regarding toxicity and uncertainties regarding tumor protection. Topical radioprotection of skin might find clinical applications with protectors such as WR-2721, but laboratory studies in which protectors have been applied in water have not been promising. We have studied the absorption
M, Sodicoff, A, Lamperti, M C, Ziskin
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Improvement of transdermal permeation of captopril by iontophoresis.
Acta pharmacologica Sinica, 2001The feasibility of iontophoresis on the transdermal delivery of captopril was studied.Iontophoresis was employed for enhancing transdermal transport of captopril through rat skin in vitro and in vivo.It was demonstrated that the iontophoresis-induced flux of captopril was affected by various factors such as pH, ionic concentration, and the ...
H, Wang, H M, Hou
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Transdermal Permeation: Physiological and Physicochemical Aspects
1991Prior to the introduction of transdermal delivery systems, topical delivery of drugs was achieved by application of ointments or creams to intact skin. When the goal was systemic therapy (e.g., nitroglycerin and estradiol ointments), reproducible dosing was extremely difficult to achieve because of the difficulty in applying uniform amounts of ointment
S. S. Hwang, K. C. Nichols, M. Southam
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In vitro transdermal permeation and penetration properties for transfersomes of brucine
China Journal of Chinese Materia Medica, 2016To prepare the liposomes and transfersomes of brucine, characterize their pharmaceutical properties, and compare their in vitro transdermal permeation properties. The liposomes and transfersomes of brucine were prepared by ammonium sulfate gradient method to investigate their pharmaceutical properties such as the particle size, encapsulation efficiency
Yu, Wu, Jun, Chen, Yun, Fang, Jie, Dong
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Transdermal permeation of tetracaine hydrochloride by lecithin microemulsion: In vivo
Colloids and Surfaces B: Biointerfaces, 2006In vivo transdermal permeation of tetracaine hydrochloride encapsulated in lecithin water-in-oil and oil-in-water microemulsion was studied. The effect of the composition of the lecithin microemulsion on analgesic response of tetracaine hydrochloride was evaluated on Wistar rats by tail flick method.
Mohammad, Changez +2 more
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Applications of ultrasonic skin permeation in transdermal drug delivery
Expert Opinion on Drug Delivery, 2008Transdermal ultrasound-mediated drug delivery has been studied as a method for needle-less, non-invasive drug administration. Potential obstacles include the stratum corneum, which is not sufficiently passively permeable to allow effective transfer of many medications into the bloodstream without active methods.
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