Results 151 to 160 of about 7,154 (195)
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Permeation Enhancers for Transdermal Drug Delivery
Drug Development and Industrial Pharmacy, 2000The transdermal route has been recognized as one of the highly potential routes of systemic drug delivery and provides the advantage of avoidance of the first-pass effect, ease of use and withdrawal (in case of side effects), and better patient compliance.
V R Sinha
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Transdermal permeation enhancement of N-trimethyl chitosan for testosterone
International Journal of Pharmaceutics, 2008The aim of this study was to evaluate the transdermal permeation enhancement of N-trimethyl chitosan (TMC) with different degrees of quaternization (DQ). TMCs with DQ of 40 and 60% (TMC40 and TMC60) were synthesized and characterized by (1)H NMR. Testosterone (TS) used as an effective drug, four different gels were prepared without enhancer, with 5 ...
Wen, He, Xianxi, Guo, Mian, Zhang
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Homoharringtonine is a transdermal granular permeation enhancer
Biochemical and Biophysical Research Communications, 2022Although modulation of claudin-1-based tight junction (TJ) in stratum granulosum is an option for transdermal absorption of drugs, granular permeation enhancers have never been developed. We previously found that homoharringtonine (HHT), a natural alkanoid, weakened intestinal epithelial barrier with changing expression and cellular localization of TJ ...
Akihiro, Watari +6 more
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Permeation-Enhancing Strategies for Transdermal Delivery of Cannabinoids
Cannabis & Cannabinoid Research, 2023Introduction: This review aims to provide an overview of the advancements and status of clinical studies and potential permeation-enhancing strategies in the transdermal delivery of cannabinoids. Methods: A systematic and comprehensive
Atefeh Torabi +2 more
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In Vitro Studies on Transdermal Permeation of Butorphanol
Drug Development and Industrial Pharmacy, 2007The influence of the donor vehicles pH and the addition of laurocapram or transkarbam 12 as permeation enhancers on the transdermal permeation of butorphanol through human skin were examined with the aim of finding out about its possible use in the transdermal delivery system.
Michal, Svozil +3 more
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Physicochemical aspects of transdermal permeation
Journal of Controlled Release, 1987Abstract The nature and state of lipids are often important regulators in many membrane functions and properties. Current studies probe the physicochemical aspects of the enhanced permeabilities of lipophilic solutes through hairless mouse stratum corneum.
K. Knutson +3 more
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Transdermal permeation of neutral molecules by skin electroporation
Journal of Controlled Release, 1998Electroporation of skin has recently been shown to enhance transport of charged molecules across skin by up to four orders of magnitude. This study demonstrates that high-voltage pulses can also increase transdermal permeation of two neutral model solutes, i.e. mannitol and water, up to 100-fold.
R, Vanbever, M A, Leroy, V, Préat
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Amino acid derivatives as transdermal permeation enhancers
Journal of Controlled Release, 2013Transdermal permeation enhancers are compounds that temporarily decrease skin barrier properties to promote drug flux. In this study, we investigated enhancers with amino acids (proline, sarcosine, alanine, β-alanine, and glycine) attached to hydrophobic chain(s) via a biodegradable ester link.
Barbora, Janůšová +11 more
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Transdermal self-permeation enhancement of ibuprofen
Journal of Controlled Release, 2004The objective of this study was to prepare saturated solutions of ibuprofen, of different concentrations, and to investigate their effect on permeation of ibuprofen across rat epidermis. Ibuprofen saturated solutions were prepared using 0.1, 0.2, 0.3 and 0.4 M disodium hydrogen phosphate solution (DHP).
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