Results 151 to 160 of about 7,205 (188)
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Amino acid derivatives as transdermal permeation enhancers
Journal of Controlled Release, 2013Transdermal permeation enhancers are compounds that temporarily decrease skin barrier properties to promote drug flux. In this study, we investigated enhancers with amino acids (proline, sarcosine, alanine, β-alanine, and glycine) attached to hydrophobic chain(s) via a biodegradable ester link.
Barbora, Janůšová +11 more
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Transdermal permeation of neutral molecules by skin electroporation
Journal of Controlled Release, 1998Electroporation of skin has recently been shown to enhance transport of charged molecules across skin by up to four orders of magnitude. This study demonstrates that high-voltage pulses can also increase transdermal permeation of two neutral model solutes, i.e. mannitol and water, up to 100-fold.
R, Vanbever, M A, Leroy, V, Préat
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Transdermal self-permeation enhancement of ibuprofen
Journal of Controlled Release, 2004The objective of this study was to prepare saturated solutions of ibuprofen, of different concentrations, and to investigate their effect on permeation of ibuprofen across rat epidermis. Ibuprofen saturated solutions were prepared using 0.1, 0.2, 0.3 and 0.4 M disodium hydrogen phosphate solution (DHP).
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Transdermal Permeation Modulation by Cyclodextrins: A Mechanistic Study
Pharmaceutical Development and Technology, 1998The purpose of this study was to investigate permeation modulation by beta- and 2-hydroxypropyl-beta-cyclodextrins (beta-CD and HP-beta-CD, respectively) alone and complexed with penetration enhancers for the test drugs 5-fluorouracil and estradiol through human skin, and to probe the value of the CDs in a barrier cream against toluene exposure ...
A C, Williams, S R, Shatri, B W, Barry
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Transkarbams with terminal branching as transdermal permeation enhancers
Bioorganic & Medicinal Chemistry Letters, 2008Transkarbams (T) represent novel group of highly active, non-toxic transdermal permeation enhancers. This study was focused on the influence of small symmetrical terminal branching on their enhancing activity. Series of T with terminal methyl or ethyl branching was prepared and their permeation-enhancing activity was compared to that of their linear ...
Jana, Klimentová +5 more
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Alaptide as Transdermal Permeation Modifier
2015Based on the fact that alaptide is able to influence the creation and function of keratinocytes, it was supposed that alaptide could be used as a transdermal permeation modifier. Various APIs (bases, acids, salts, neutral molecules, small molecules, steroid-like molecules) were tested on their transdermal permeation in the mixture with micronized and ...
Josef Jampílek, Jiří Dohnal
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An investigation of the effect of surfactants on transdermal permeation
1994The aim of this study was to investigate the direct effects of surfactants on the stratum corneum, and thus propose mechanisms of action for these compounds as penetration enhancers. The main methods used in the study were: determination of the permeability of neonatal rat stratum corneum to propan-2-ol; differential scanning calorimetry (DSC); Fourier
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[Influence of permeation enhancers on transdermal permeation of anemonin].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2008To investigate the effect of different permeation enhancer on transdermal permeation of anemonin through human skin.The permeation experiments were performed using human skin on modified Franz diffusion cells in vitro. The concentrations of anemonin in receptor compartment at specified time points were determined by HPLC.
Yu-Ming, Ning +2 more
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Permeation enhancers in transdermal drug delivery: benefits and limitations
Expert Opinion on Drug Delivery, 2020Introduction: Transdermal drug delivery has several clinical benefits over conventional routes of drug administration. To open the transdermal route for a wider range of drugs, including macromolecules, numerous physical and chemical techniques to overcome the natural low skin permeability have been developed.Areas covered: This review focuses on ...
Andrej Kováčik +2 more
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Solubility and in vitro transdermal permeation of nifedipine
International Journal of Pharmaceutics, 1997Abstract The solubilities of a hydrophobic drug, nifedipine, in a diverse panel of solvent and cosolvent systems were determined experimentally at room temperature. The observed solubilities were examined for deviations from regular solution solubilities as calculated by the Hildebrand and Scott Equation.
Emilio Squillante +2 more
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