Results 131 to 140 of about 93,495 (232)

Optimisation of Topical and Transdermal Pharmaceutical Formulations: Methods, Challenges and Opportunities

SmartSys, Volume 2, Issue 4, December 2026.
ABSTRACT Topical and transdermal pharmaceutical formulations are a large and diverse class of products, yet their optimisation remains a complex, resource‐intensive challenge. Statistical design‐of‐experiments approaches have long provided the methodological backbone for this process and have shown broad effectiveness across topical and transdermal ...
Yongrui Xiao, Yu Zhang, Chunlin Chen, Dimitrios Tsaoulidis, Kai Yang, Tao Chen   +5 more
wiley   +1 more source

Challenges and opportunities in dermal/transdermal delivery

, 2010
Transdermal drug delivery is an exciting and challenging area. There are numerous transdermal delivery systems currently available on the market. However, the transdermal market still remains limited to a narrow range of drugs.
Nicole K Brogden, Mikolaj Milewski, Kalpana S Paudel, Courtney L Swadley, Audra L Stinchcomb, Priyanka Ghosh   +5 more
core   +1 more source

Skin Models for Nanoemulgel Permeation: An Overview of Current Practices

Precision Nanomedicine
Transdermal drug delivery systems are gaining increasing interest due to their ability to bypass first-pass metabolism in the liver and provide better patient compliance while delivering drugs through a controlled-release mechanism.
Anni’sya Alfanura, Farida Hayati, Oktavia Indrati   +2 more
doaj   +1 more source

Ginger Extract–Loaded Transethosomes for Effective Transdermal Permeation and Anti-Inflammation in Rat Model

, 2023
Abeer S Hassan,1 Amal Hofni,2 Mohammed AS Abourehab,3 Iman AM Abdel-Rahman4 1Department of Pharmaceutics, Faculty of Pharmacy, South Valley University, Qena, Egypt; 2Department of Pharmacology and Toxicology, Faculty of Pharmacy, South Valley University,
Hofni A, Abdel-Rahman IAM, Hassan AS, Abourehab MAS   +3 more
core  

Chemical permeation enhancers and their use in transdermal drug delivery [PDF]

, 2020
The field of medicine has advanced such that we are now capable of combating many disorders through the use of carefully studied, well-developed therapeutics.
Khan, Fariha
core  

Optimizing and Evaluating the Transdermal Permeation of Hydrocortisone Transfersomes Formulation Based on Digital Analysis of the In Vitro Drug Release and Ex Vivo Studies. [PDF]

Recent Adv Drug Deliv Formul, 2022
Abdelwahd A, Abdul Rasool BK.
europepmc   +1 more source

Advanced Materials for Biologics Delivery to Brain Tumors

Advanced Materials, Volume 38, Issue 61, 2 November 2026.
Material innovation is central to unlocking the therapeutic potential of biologics against many central nervous system diseases, including brain cancer. By engineering carriers with controlled transport, targeting, and release properties, advanced materials can overcome the blood–brain barrier and tumor microenvironment, improving the delivery of ...
Yuran Feng, Yuxue Cao, Maria Kavallaris, Taskeen Janjua, Amirali Popat   +4 more
wiley   +1 more source

Development of Novel Furan–Chalcone Derivatives as Targeting Bacterial DNA Gyrase and Topoisomerase IV: Design, Synthesis, and In Silico Studies

Chemistry &Biodiversity, Volume 23, Issue 11, November 2026.
Furan–chalcone derivatives (Na1–Na8) were successfully designed, synthesized, and biologically evaluated using integrated experimental and computational approaches. ABSTRACT A series of novel furan–chalcone derivatives (Na1–Na8) were synthesized and evaluated for their antimicrobial, antioxidant, DNA gyrase inhibitory, and computational properties ...
Nagaraj N Durgadasheemi, Vishal CS
wiley   +1 more source

Posttranslational Modification Cross‐Talk in Vascular Cells: Molecular Mechanisms and Therapeutic Implications for Atherosclerosis

Cell Biochemistry and Function, Volume 44, Issue 11, November 2026.
ABSTRACT Atherosclerosis is driven by coordinated changes in endothelial cells (ECs), macrophages, and vascular smooth muscle cells (VSMCs). Post‐translational modifications (PTMs), phosphorylation, acetylation, ubiquitination, SUMOylation, O‐GlcNAcylation, palmitoylation, ISGylation, and ADP‐ribosylation, integrate metabolic, inflammatory, and ...
Weiwei Jiang, Haiping Du
wiley   +1 more source

Vehicle Optimization of Topical Clobetasol Propionate in Disseminated Granuloma Annulare: Clinical Insights From Two Cases

Clinical Case Reports, Volume 14, Issue 11, November 2026.
ABSTRACT Vehicle composition may influence topical corticosteroid performance. In two patients with disseminated granuloma annulare, switching from clobetasol ointment to the same‐strength solution in diethylene glycol monoethyl ether (DEGEE) was followed by complete clearance, suggesting formulation optimization may be considered when topical ...
Alexandre Raphael Meduri, Giorgia Sbarra, Giulia Ciccarese, Paolo Danza, Vincenzo Scarano, Francesca Ambrogio, William Andrew Rosato, Gerardo Cazzato, Mario Della Mura, Giuseppe Demichele, Caterina Foti   +10 more
wiley   +1 more source