Results 141 to 150 of about 93,495 (232)

From Prediction to Decision Making: PBPK and QSP as Regulatory‐Grade NAMs

Clinical Pharmacology &Therapeutics, Volume 120, Issue 5, Page 1195-1207, November 2026.
New approach methodologies (NAMs) encompass a diverse and rapidly evolving set of experimental and computational tools designed to generate human‐relevant mechanistic data for use in drug development and regulatory decision making. Experimental NAMs provide insights into drug disposition, pharmacological activity, and disease biology that are difficult
Karen Rowland Yeo, Piet H. van der Graaf
wiley   +1 more source

TRANSDERMAL DRUG DELIVERY SYSTEMS

Transdermal drug delivery systems (TDDS) have emerged as a promising and patient-friendly alternative to conventional routes of drug administration.
Dr. Anita R Desai, Sushmita Mudalagi
core   +1 more source

Curcumin in the Treatment of Various Diseases: Mechanism of Action, Bioavailability, Therapeutic Effects, and Current Clinical Trials

MedComm, Volume 7, Issue 11, November 2026.
Curcumin, a naturally occurring polyphenol, exhibits significant anti‐inflammatory and antioxidant capabilities. This review elucidates the specific molecular mechanisms by which curcumin exerts therapeutic effects on various diseases, including neurological disorders, cardiovascular diseases, cancers, inflammatory disorders, and autoimmune diseases ...
Lin Wang, Qifei Pan, Wenjuan Long, Xinyao Li, Jianqin Mao, Sitong Zhou, Zihui Wang, Xuelian Zou, Yuqing She, Mingqin Shi, Yang Zhou, Jiarong Du, Zhongyang Hu, Xiaoman Lv, Yishu Chen, Dongdong Qin   +15 more
wiley   +1 more source

Formulation and optimization of upadacitinib-loaded transdermal patches for rheumatoid arthritis with zero-order release kinetics

Journal of Applied Pharmaceutical Research
Background: To develop and optimize Upadacitinib-loaded transdermal patches for rheumatoid arthritis treatment with improved patient compliance and sustained drug delivery.
Shubham Talole, Rahul Godge, Nikita Tambe, Nikita Mhase   +3 more
doaj   +1 more source

Electrospun PVA Scaffolds Containing MCM‐41/CNC Nanocomposites for Controlled Drug Release in Wound Dressings

Polymer Engineering &Science, Volume 66, Issue 11, Page 8051-8065, November 2026.
Cellulose nanocrystals extracted from Mauritia flexuosa petiole were combined with MCM‐41 mesoporous silica to create a diclofenac‐loaded hybrid nanocomposite. Incorporation into electrospun PVA scaffolds enabled controlled diclofenac release and high cell viability, highlighting their potential for localized drug delivery.
Karoliny V. Barbosa, Marcos G. M. Brandão, Alex Rojas, Lucas Dall Agnol, Ana Luisa C. Carvalho, Leonardo T. B. Mendonça, Ana C. S. Alcântara, Rebecca J. P. Araujo, Severino Alves Jr., Dayane K. D. N. Santos, Walter M. de Azevedo, Gricirene S. Correia   +11 more
wiley   +1 more source

Percutaneous Vertebroplasty for Painful Osteoporotic Vertebral Compression Fractures: A Retrospective Comparative Study of a Negative Pressure‐Guided Technique

Orthopaedic Surgery, Volume 18, Issue 11, Page 2380-2390, November 2026.
In 60 patients with vertebral compression fractures, negative‐pressure‐guided vertebroplasty (NPVP) promoted more uniform cement distribution and reduced cement leakage compared with conventional PVP, resulting in greater perioperative safety and improved radiographic and clinical outcomes at 3 months.
Botao Zhang, Zihan Wang, Shibing Zhang, Zhipeng Xi, Xin Chen, Qingyuan Ru, Ke Wu, Rongrong Deng, Xin Liu, Ran Kang   +9 more
wiley   +1 more source

Terahertz Time‐Domain Spectroscopy as a Probe of Skin Viscoelasticity

Skin Research and Technology, Volume 32, Issue 11, November 2026.
ABSTRACT In both a cosmetic and clinical setting, there is a strong demand for the development of quantitative methods to assess skin condition and monitor treatment progress. Terahertz (THz) light has shown promise for non‐invasive skin evaluation, in particular for classifying between diseased and healthy tissue based on the differences in dielectric
Benjamin George Page, Xiangyu Guo, Rayko Ivanov Stantchev, Joseph Hardwicke, Emma Pickwell‐MacPherson   +4 more
wiley   +1 more source

Design Considerations for Polymer–Deep Eutectic Solvent Hybrid Systems for Transdermal Drug Delivery

Journal of Applied Polymer Science, Volume 143, Issue 40, October 20, 2026.
Deep eutectic solvents (DESs) act as tunable, green excipients that modulate polymer structure–property relationships to enhance drug solubility, skin permeation, stability, and controlled release. Through hydrogen‐bond interactions, DES–polymer hybrid systems enable improved transdermal performance, offering a rational, design‐driven platform for ...
Madhavi Kailas Kapale, Madhur Kulkarni, Pranav J. Shah, Furqan A. Maulvi   +3 more
wiley   +1 more source

Complex Drug Delivery Systems: Controlling Transdermal Permeation Rates with Multiple Active Pharmaceutical Ingredients. [PDF]

AAPS PharmSciTech, 2020
Davis DA, Martins PP, Zamloot MS, Kucera SA, Williams RO, Smyth HDC, Warnken ZN.   +6 more
europepmc   +1 more source

Chiral 4-O-acylterpineol as transdermal permeation enhancers: insights of the enhancement mechanisms of a transdermal enantioselective delivery system for flurbiprofen. [PDF]

Drug Deliv, 2020
Chu T, Wang C, Wang J, Wang H, Geng D, Wu C, Zhao L, Zhao L.   +7 more
europepmc   +1 more source