Results 161 to 170 of about 7,205 (188)
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Transdermal Permeation: Physiological and Physicochemical Aspects
1991Prior to the introduction of transdermal delivery systems, topical delivery of drugs was achieved by application of ointments or creams to intact skin. When the goal was systemic therapy (e.g., nitroglycerin and estradiol ointments), reproducible dosing was extremely difficult to achieve because of the difficulty in applying uniform amounts of ointment
S. S. Hwang, K. C. Nichols, M. Southam
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Biodegradable derivatives of tranexamic acid as transdermal permeation enhancers
Journal of Controlled Release, 2005The purpose of this work was to develop a novel approach to transdermal permeation enhancer design, based on utilizing some favorable properties of their metabolites. As an example of this concept, a series of carbamic acid salts of tranexamic acid (TXA) esters was synthesized, because TXA was previously shown to improve skin barrier homeostasis ...
Katerina, Vávrová +4 more
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An investigation of some factors affecting transdermal permeation
1985Factors affecting transdermal permeation were investigated using Differential Thermal Anlaysis (DTA) and in vitro penetration studies of neonatal rat stratum corneum (s.c.), with radiolabelled propanol and hexanol as penetrants. Thermogravimetric Analysis, Thin-Layer Chromatography (TLC) and Infrared Spectroscopy were used to provide additional ...
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Amphiphilic Transdermal Permeation Enhancers: Structure-Activity Relationships
Current Medicinal Chemistry, 2005Transdermal drug delivery offers numerous advantages over conventional routes of administration; however, poor permeation of most drugs across the skin barrier constitutes a serious limitation of this methodology. One of the approaches used to enlarge the number of transdermally-applicable drugs uses permeation enhancers.
K, Vávrová +2 more
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An Electrochemical Transdermal Patch for Permeation Enhancement
2017A novel electrochemical patch is described that works by the hydrolysis of water in a hydrogel between two suitable electrodes that produces a strongly enhanced drug flux through the skin. This non-iontophoretic mechanism requires only a short voltage application (60 s) yet produces enhanced skin permeation over up to 5 h.
Geoffrey Lee +3 more
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Design of improved permeation enhancers for transdermal drug delivery
Journal of Pharmaceutical Sciences, 2009One promising way to breach the skin's natural barrier to drugs is by the application of chemicals called penetration enhancers. However, identifying potential enhancers is difficult and time consuming. We have developed a virtual screening algorithm for generating potential chemical penetration enhancers (CPEs) by integrating nonlinear, theory-based ...
Srinivas S, Godavarthy +6 more
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Sucrose Esters as Transdermal Permeation Enhancers
2015Surfactants are widely used excipients in topical formulations, not only for their solubilizing and emulsifying properties but also for their well-known capacity to enhance drug permeation. Although nonionic surfactants are frequently chosen because of their mild effect on the skin, they share a low efficacy as permeation enhancers.
María Guadalupe Nava-Arzaluz +2 more
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Transdermal delivery of naloxone: ex vivo permeation studies
International Journal of Pharmaceutics, 1999The purpose of this investigation was to study the feasibility of transdermal drug delivery of the potent opioid antagonist naloxone. The pharmacokinetic profile of naloxone makes it a suitable candidate for transdermal delivery. Ex vivo permeation of naloxone through excised rat skin was studied using a diffusion cell.
J, Jaiswal, R, Poduri, R, Panchagnula
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Transdermal Absorption of Radioprotectors Using Permeation-Enhancing Vehicles
Radiation Research, 1990Radioprotectors are not currently used clinically due to concerns regarding toxicity and uncertainties regarding tumor protection. Topical radioprotection of skin might find clinical applications with protectors such as WR-2721, but laboratory studies in which protectors have been applied in water have not been promising. We have studied the absorption
M, Sodicoff, A, Lamperti, M C, Ziskin
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Improvement of transdermal permeation of captopril by iontophoresis.
Acta pharmacologica Sinica, 2001The feasibility of iontophoresis on the transdermal delivery of captopril was studied.Iontophoresis was employed for enhancing transdermal transport of captopril through rat skin in vitro and in vivo.It was demonstrated that the iontophoresis-induced flux of captopril was affected by various factors such as pH, ionic concentration, and the ...
H, Wang, H M, Hou
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