Results 161 to 170 of about 7,154 (195)
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Transdermal Permeation Modulation by Cyclodextrins: A Mechanistic Study
Pharmaceutical Development and Technology, 1998The purpose of this study was to investigate permeation modulation by beta- and 2-hydroxypropyl-beta-cyclodextrins (beta-CD and HP-beta-CD, respectively) alone and complexed with penetration enhancers for the test drugs 5-fluorouracil and estradiol through human skin, and to probe the value of the CDs in a barrier cream against toluene exposure ...
A C, Williams, S R, Shatri, B W, Barry
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Transkarbams with terminal branching as transdermal permeation enhancers
Bioorganic & Medicinal Chemistry Letters, 2008Transkarbams (T) represent novel group of highly active, non-toxic transdermal permeation enhancers. This study was focused on the influence of small symmetrical terminal branching on their enhancing activity. Series of T with terminal methyl or ethyl branching was prepared and their permeation-enhancing activity was compared to that of their linear ...
Jana, Klimentová +5 more
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Alaptide as Transdermal Permeation Modifier
2015Based on the fact that alaptide is able to influence the creation and function of keratinocytes, it was supposed that alaptide could be used as a transdermal permeation modifier. Various APIs (bases, acids, salts, neutral molecules, small molecules, steroid-like molecules) were tested on their transdermal permeation in the mixture with micronized and ...
Josef Jampílek, Jiří Dohnal
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An investigation of the effect of surfactants on transdermal permeation
1994The aim of this study was to investigate the direct effects of surfactants on the stratum corneum, and thus propose mechanisms of action for these compounds as penetration enhancers. The main methods used in the study were: determination of the permeability of neonatal rat stratum corneum to propan-2-ol; differential scanning calorimetry (DSC); Fourier
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[Influence of permeation enhancers on transdermal permeation of anemonin].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2008To investigate the effect of different permeation enhancer on transdermal permeation of anemonin through human skin.The permeation experiments were performed using human skin on modified Franz diffusion cells in vitro. The concentrations of anemonin in receptor compartment at specified time points were determined by HPLC.
Yu-Ming, Ning +2 more
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Solubility and in vitro transdermal permeation of nifedipine
International Journal of Pharmaceutics, 1997Abstract The solubilities of a hydrophobic drug, nifedipine, in a diverse panel of solvent and cosolvent systems were determined experimentally at room temperature. The observed solubilities were examined for deviations from regular solution solubilities as calculated by the Hildebrand and Scott Equation.
Emilio Squillante +2 more
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Permeation enhancers in transdermal drug delivery: benefits and limitations
Expert Opinion on Drug Delivery, 2020Introduction: Transdermal drug delivery has several clinical benefits over conventional routes of drug administration. To open the transdermal route for a wider range of drugs, including macromolecules, numerous physical and chemical techniques to overcome the natural low skin permeability have been developed.Areas covered: This review focuses on ...
Andrej Kováčik +2 more
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Biodegradable derivatives of tranexamic acid as transdermal permeation enhancers
Journal of Controlled Release, 2005The purpose of this work was to develop a novel approach to transdermal permeation enhancer design, based on utilizing some favorable properties of their metabolites. As an example of this concept, a series of carbamic acid salts of tranexamic acid (TXA) esters was synthesized, because TXA was previously shown to improve skin barrier homeostasis ...
Katerina, Vávrová +4 more
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An investigation of some factors affecting transdermal permeation
1985Factors affecting transdermal permeation were investigated using Differential Thermal Anlaysis (DTA) and in vitro penetration studies of neonatal rat stratum corneum (s.c.), with radiolabelled propanol and hexanol as penetrants. Thermogravimetric Analysis, Thin-Layer Chromatography (TLC) and Infrared Spectroscopy were used to provide additional ...
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Amphiphilic Transdermal Permeation Enhancers: Structure-Activity Relationships
Current Medicinal Chemistry, 2005Transdermal drug delivery offers numerous advantages over conventional routes of administration; however, poor permeation of most drugs across the skin barrier constitutes a serious limitation of this methodology. One of the approaches used to enlarge the number of transdermally-applicable drugs uses permeation enhancers.
K, Vávrová +2 more
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