Results 201 to 210 of about 93,495 (232)

Solubility and in vitro transdermal permeation of nifedipine

International Journal of Pharmaceutics, 1997
Abstract The solubilities of a hydrophobic drug, nifedipine, in a diverse panel of solvent and cosolvent systems were determined experimentally at room temperature. The observed solubilities were examined for deviations from regular solution solubilities as calculated by the Hildebrand and Scott Equation.
Emilio Squillante, Thomas Needham, Hossein Zia   +2 more
openaire   +1 more source

[Influence of permeation enhancers on transdermal permeation of anemonin].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2008
To investigate the effect of different permeation enhancer on transdermal permeation of anemonin through human skin.The permeation experiments were performed using human skin on modified Franz diffusion cells in vitro. The concentrations of anemonin in receptor compartment at specified time points were determined by HPLC.
Yu-Ming, Ning, Yue-Feng, Rao, Wen-Quan, Liang   +2 more
openaire   +1 more source

Permeation enhancers in transdermal drug delivery: benefits and limitations

Expert Opinion on Drug Delivery, 2020
Introduction: Transdermal drug delivery has several clinical benefits over conventional routes of drug administration. To open the transdermal route for a wider range of drugs, including macromolecules, numerous physical and chemical techniques to overcome the natural low skin permeability have been developed.Areas covered: This review focuses on ...
Andrej Kováčik, Monika Kopečná, Kateřina Vávrová   +2 more
openaire   +2 more sources

Transdermal Permeation: Physiological and Physicochemical Aspects

1991
Prior to the introduction of transdermal delivery systems, topical delivery of drugs was achieved by application of ointments or creams to intact skin. When the goal was systemic therapy (e.g., nitroglycerin and estradiol ointments), reproducible dosing was extremely difficult to achieve because of the difficulty in applying uniform amounts of ointment
S. S. Hwang, K. C. Nichols, M. Southam
openaire   +1 more source

Transdermal Permeation Enhancement of N-Trimethyl Chitosan for Testosterone

International Journal of Pharmaceutics, 2008
The aim of this study was to evaluate the transdermal permeation enhancement of N-trimethyl chitosan (TMC) with different degrees of quaternization (DQ). TMCs with DQ of 40 and 60% (TMC40 and TMC60) were synthesized and characterized by (1)H NMR. Testosterone (TS) used as an effective drug, four different gels were prepared without enhancer, with 5 ...
Wen, He, Xianxi, Guo, Mian, Zhang
exaly   +3 more sources

Biodegradable derivatives of tranexamic acid as transdermal permeation enhancers

Journal of Controlled Release, 2005
The purpose of this work was to develop a novel approach to transdermal permeation enhancer design, based on utilizing some favorable properties of their metabolites. As an example of this concept, a series of carbamic acid salts of tranexamic acid (TXA) esters was synthesized, because TXA was previously shown to improve skin barrier homeostasis ...
Katerina, Vávrová, Alexandr, Hrabálek, Pavel, Dolezal, Tomás, Holas, Jana, Klimentová   +4 more
openaire   +2 more sources

An investigation of some factors affecting transdermal permeation

1985
Factors affecting transdermal permeation were investigated using Differential Thermal Anlaysis (DTA) and in vitro penetration studies of neonatal rat stratum corneum (s.c.), with radiolabelled propanol and hexanol as penetrants. Thermogravimetric Analysis, Thin-Layer Chromatography (TLC) and Infrared Spectroscopy were used to provide additional ...
openaire   +2 more sources

An Electrochemical Transdermal Patch for Permeation Enhancement

2017
A novel electrochemical patch is described that works by the hydrolysis of water in a hydrogel between two suitable electrodes that produces a strongly enhanced drug flux through the skin. This non-iontophoretic mechanism requires only a short voltage application (60 s) yet produces enhanced skin permeation over up to 5 h.
Geoffrey Lee, Britta Schröder, Ulrich Nickel, Elisabeth Meyer   +3 more
openaire   +1 more source

Design of improved permeation enhancers for transdermal drug delivery

Journal of Pharmaceutical Sciences, 2009
One promising way to breach the skin's natural barrier to drugs is by the application of chemicals called penetration enhancers. However, identifying potential enhancers is difficult and time consuming. We have developed a virtual screening algorithm for generating potential chemical penetration enhancers (CPEs) by integrating nonlinear, theory-based ...
Srinivas S, Godavarthy, Krishna M, Yerramsetty, Vijay K, Rachakonda, Brian J, Neely, Sundararajan V, Madihally, Robert L, Robinson, Khaled A M, Gasem   +6 more
openaire   +2 more sources

Amphiphilic Transdermal Permeation Enhancers: Structure-Activity Relationships

Current Medicinal Chemistry, 2005
Transdermal drug delivery offers numerous advantages over conventional routes of administration; however, poor permeation of most drugs across the skin barrier constitutes a serious limitation of this methodology. One of the approaches used to enlarge the number of transdermally-applicable drugs uses permeation enhancers.
K, Vávrová, J, Zbytovská, A, Hrabálek   +2 more
openaire   +2 more sources