Results 201 to 210 of about 17,365 (234)

Transdermal Absorption of Radioprotectors Using Permeation-Enhancing Vehicles

Radiation Research, 1990
Radioprotectors are not currently used clinically due to concerns regarding toxicity and uncertainties regarding tumor protection. Topical radioprotection of skin might find clinical applications with protectors such as WR-2721, but laboratory studies in which protectors have been applied in water have not been promising. We have studied the absorption
M, Sodicoff, A, Lamperti, M C, Ziskin
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Transkarbams with terminal branching as transdermal permeation enhancers

Bioorganic & Medicinal Chemistry Letters, 2008
Transkarbams (T) represent novel group of highly active, non-toxic transdermal permeation enhancers. This study was focused on the influence of small symmetrical terminal branching on their enhancing activity. Series of T with terminal methyl or ethyl branching was prepared and their permeation-enhancing activity was compared to that of their linear ...
Jana, Klimentová, Petr, Kosák, Katerina, Vávrová, Tomás, Holas, Jakub, Novotný, Alexandr, Hrabálek   +5 more
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Sucrose Esters as Transdermal Permeation Enhancers

2015
Surfactants are widely used excipients in topical formulations, not only for their solubilizing and emulsifying properties but also for their well-known capacity to enhance drug permeation. Although nonionic surfactants are frequently chosen because of their mild effect on the skin, they share a low efficacy as permeation enhancers.
María Guadalupe Nava-Arzaluz, Elizabeth Piñón-Segundo, Adriana Ganem-Rondero   +2 more
openaire   +1 more source

Mechanistic Insights into High Permeation Vesicle-Mediated Synergistic Enhancement of Transdermal Drug Permeation

Nanomedicine, 2019
Aim: To design a nanocarrier platform for enhanced transdermal drug permeation. Materials & methods: Gel-based high permeation vesicles (HPVs) were developed and their performance in terms of transdermal flux improvement, in vitro release and skin irritancy was assessed.
Sanyog, Jain, Pragati, Khare, Tushar, Date, Sameer S, Katiyar, Varun, Kushwah, Mahesh K, Katariya, Rajan, Swami   +6 more
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Transdermal Permeation: Physiological and Physicochemical Aspects

1991
Prior to the introduction of transdermal delivery systems, topical delivery of drugs was achieved by application of ointments or creams to intact skin. When the goal was systemic therapy (e.g., nitroglycerin and estradiol ointments), reproducible dosing was extremely difficult to achieve because of the difficulty in applying uniform amounts of ointment
S. S. Hwang, K. C. Nichols, M. Southam
openaire   +1 more source

Permeation-Enhancing Strategies for Transdermal Delivery of Cannabinoids

Cannabis and Cannabinoid Research
Introduction: This review aims to provide an overview of the advancements and status of clinical studies and potential permeation-enhancing strategies in the transdermal delivery of cannabinoids. Methods: A systematic and comprehensive literature search across academic databases, search engines, and online sources to identify relevant literature on the
Atefeh Torabi, Frederikke Bahrt Madsen, Anne Ladegaard Skov   +2 more
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Design of improved permeation enhancers for transdermal drug delivery

Journal of Pharmaceutical Sciences, 2009
One promising way to breach the skin's natural barrier to drugs is by the application of chemicals called penetration enhancers. However, identifying potential enhancers is difficult and time consuming. We have developed a virtual screening algorithm for generating potential chemical penetration enhancers (CPEs) by integrating nonlinear, theory-based ...
Srinivas S, Godavarthy, Krishna M, Yerramsetty, Vijay K, Rachakonda, Brian J, Neely, Sundararajan V, Madihally, Robert L, Robinson, Khaled A M, Gasem   +6 more
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Biodegradable derivatives of tranexamic acid as transdermal permeation enhancers

Journal of Controlled Release, 2005
The purpose of this work was to develop a novel approach to transdermal permeation enhancer design, based on utilizing some favorable properties of their metabolites. As an example of this concept, a series of carbamic acid salts of tranexamic acid (TXA) esters was synthesized, because TXA was previously shown to improve skin barrier homeostasis ...
Katerina, Vávrová, Alexandr, Hrabálek, Pavel, Dolezal, Tomás, Holas, Jana, Klimentová   +4 more
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[Influence of permeation enhancers on transdermal permeation of anemonin].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2008
To investigate the effect of different permeation enhancer on transdermal permeation of anemonin through human skin.The permeation experiments were performed using human skin on modified Franz diffusion cells in vitro. The concentrations of anemonin in receptor compartment at specified time points were determined by HPLC.
Yu-Ming, Ning, Yue-Feng, Rao, Wen-Quan, Liang   +2 more
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Transdermal permeation of apomorphine through hairless mouse skin from microemulsions

International Journal of Pharmaceutics, 2001
The in vitro transdermal absorption of apomorphine from microemulsions was studied using the skin of the hairless mouse as a membrane. Two microemulsions (no. 1 and 2) were prepared and thickened both containing 3.9% of apomorphine hydrochloride. The lipophilicity of the drug was increased by forming apomorphine-octanoic acid ion-pairs.
PEIRA, Elena, SCOLARI P, GASCO, Maria Rosa   +2 more
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