Results 221 to 230 of about 17,319 (246)

Transdermal delivery of naloxone: ex vivo permeation studies

International Journal of Pharmaceutics, 1999
The purpose of this investigation was to study the feasibility of transdermal drug delivery of the potent opioid antagonist naloxone. The pharmacokinetic profile of naloxone makes it a suitable candidate for transdermal delivery. Ex vivo permeation of naloxone through excised rat skin was studied using a diffusion cell.
J, Jaiswal, R, Poduri, R, Panchagnula
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Transdermal Permeation Modulation by Cyclodextrins: A Mechanistic Study

Pharmaceutical Development and Technology, 1998
The purpose of this study was to investigate permeation modulation by beta- and 2-hydroxypropyl-beta-cyclodextrins (beta-CD and HP-beta-CD, respectively) alone and complexed with penetration enhancers for the test drugs 5-fluorouracil and estradiol through human skin, and to probe the value of the CDs in a barrier cream against toluene exposure ...
A C, Williams, S R, Shatri, B W, Barry
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Transdermal Absorption of Radioprotectors Using Permeation-Enhancing Vehicles

Radiation Research, 1990
Radioprotectors are not currently used clinically due to concerns regarding toxicity and uncertainties regarding tumor protection. Topical radioprotection of skin might find clinical applications with protectors such as WR-2721, but laboratory studies in which protectors have been applied in water have not been promising. We have studied the absorption
M, Sodicoff, A, Lamperti, M C, Ziskin
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Transkarbams with terminal branching as transdermal permeation enhancers

Bioorganic & Medicinal Chemistry Letters, 2008
Transkarbams (T) represent novel group of highly active, non-toxic transdermal permeation enhancers. This study was focused on the influence of small symmetrical terminal branching on their enhancing activity. Series of T with terminal methyl or ethyl branching was prepared and their permeation-enhancing activity was compared to that of their linear ...
Jana, Klimentová, Petr, Kosák, Katerina, Vávrová, Tomás, Holas, Jakub, Novotný, Alexandr, Hrabálek   +5 more
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Sucrose Esters as Transdermal Permeation Enhancers

2015
Surfactants are widely used excipients in topical formulations, not only for their solubilizing and emulsifying properties but also for their well-known capacity to enhance drug permeation. Although nonionic surfactants are frequently chosen because of their mild effect on the skin, they share a low efficacy as permeation enhancers.
María Guadalupe Nava-Arzaluz, Elizabeth Piñón-Segundo, Adriana Ganem-Rondero   +2 more
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Mechanistic Insights into High Permeation Vesicle-Mediated Synergistic Enhancement of Transdermal Drug Permeation

Nanomedicine, 2019
Aim: To design a nanocarrier platform for enhanced transdermal drug permeation. Materials & methods: Gel-based high permeation vesicles (HPVs) were developed and their performance in terms of transdermal flux improvement, in vitro release and skin irritancy was assessed.
Sanyog, Jain, Pragati, Khare, Tushar, Date, Sameer S, Katiyar, Varun, Kushwah, Mahesh K, Katariya, Rajan, Swami   +6 more
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Transdermal Permeation: Physiological and Physicochemical Aspects

1991
Prior to the introduction of transdermal delivery systems, topical delivery of drugs was achieved by application of ointments or creams to intact skin. When the goal was systemic therapy (e.g., nitroglycerin and estradiol ointments), reproducible dosing was extremely difficult to achieve because of the difficulty in applying uniform amounts of ointment
S. S. Hwang, K. C. Nichols, M. Southam
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Permeation enhancers in transdermal drug delivery: benefits and limitations

Expert Opinion on Drug Delivery, 2020
Introduction: Transdermal drug delivery has several clinical benefits over conventional routes of drug administration. To open the transdermal route for a wider range of drugs, including macromolecules, numerous physical and chemical techniques to overcome the natural low skin permeability have been developed.Areas covered: This review focuses on ...
Andrej Kováčik, Monika Kopečná, Kateřina Vávrová   +2 more
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Permeation-Enhancing Strategies for Transdermal Delivery of Cannabinoids

Cannabis and Cannabinoid Research
Introduction: This review aims to provide an overview of the advancements and status of clinical studies and potential permeation-enhancing strategies in the transdermal delivery of cannabinoids. Methods: A systematic and comprehensive literature search across academic databases, search engines, and online sources to identify relevant literature on the
Atefeh Torabi, Frederikke Bahrt Madsen, Anne Ladegaard Skov   +2 more
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Design of improved permeation enhancers for transdermal drug delivery

Journal of Pharmaceutical Sciences, 2009
One promising way to breach the skin's natural barrier to drugs is by the application of chemicals called penetration enhancers. However, identifying potential enhancers is difficult and time consuming. We have developed a virtual screening algorithm for generating potential chemical penetration enhancers (CPEs) by integrating nonlinear, theory-based ...
Srinivas S, Godavarthy, Krishna M, Yerramsetty, Vijay K, Rachakonda, Brian J, Neely, Sundararajan V, Madihally, Robert L, Robinson, Khaled A M, Gasem   +6 more
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