Results 101 to 110 of about 2,619,685 (255)

Genetic incorporation of the protein transduction domain of Tat into Ad5 fiber enhances gene transfer efficacy-0

, 2011
Copyright information:Taken from "Genetic incorporation of the protein transduction domain of Tat into Ad5 fiber enhances gene transfer efficacy"http://www.virologyj.com/content/4/1/103Virology Journal 2007;4():103-103.Published online 24 Oct 2007PMCID ...
Leslie E Perry (82823), Gene P Siegal (15416), Hideyo Ugai (82822), Hongju Wu (82825), Juan L Contreras (82824), Tie Han (82820), Yizhe Tang (82821)   +6 more
core   +1 more source

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

FEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen, Duc Trung Nguyen, Minyoung Cho, Jihun Kim, Soyeon In, Thai Uy Nguyen, Sunghoon Hurh, Beom Jin Park, Jong‐Ik Hwang   +8 more
wiley   +1 more source

Genetic dissection of human ABCE1 in yeast reveals separable requirements for ribosome recycling and suppression of aberrant reinitiation

FEBS Open Bio, EarlyView.
Human ABCE1 cannot functionally replace its yeast ortholog. Yeast–human chimera analysis identified NBD1 as a major interspecies barrier. Genetic screening yielded hABCE1 revertants that rescue yeast viability but fail to suppress aberrant translation reinitiation in the 3′ UTR.
Eriko Nakata, Yuxin Li, Kei Endo, Koichi Ito   +3 more
wiley   +1 more source

Genetic incorporation of the protein transduction domain of Tat into Ad5 fiber enhances gene transfer efficacy-6

, 2011
Copyright information:Taken from "Genetic incorporation of the protein transduction domain of Tat into Ad5 fiber enhances gene transfer efficacy"http://www.virologyj.com/content/4/1/103Virology Journal 2007;4():103-103.Published online 24 Oct 2007PMCID ...
Leslie E Perry (82823), Gene P Siegal (15416), Hideyo Ugai (82822), Hongju Wu (82825), Juan L Contreras (82824), Tie Han (82820), Yizhe Tang (82821)   +6 more
core   +1 more source

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

Control Design for Signal Transduction Networks

, 2009
Signal transduction networks of biological systems are highly complex. How to mathematically describe a signal transduction network by systematic approaches to further develop an appropriate and effective control strategy is attractive to control ...
Chun-Liang Lin, Chia-Hua Chuang, Yuan-Wei Liu   +2 more
core   +1 more source

Type I interferons modulate autophagy to shape gemcitabine response in pancreatic cancer cells

FEBS Open Bio, EarlyView.
Type I interferons differentially modulate autophagy and the response of pancreatic cancer cells to gemcitabine. IFNα2b stimulates autophagic flux and protects cells from gemcitabine‐induced cell death, contributing to chemoresistance. In contrast, IFNβ1a inhibits autophagosome formation and enhances gemcitabine‐induced cell death, resulting in ...
Lucy E. Bonilla, Martín M. Ledesma, Santiago A. Behr, Matías A. Pibuel, María L. Palanek, Daniel H. Grasso, Maria N. Garcia, Juan Garona, Silvina L. Lompardía, Elida Álvarez, Daniela L. Papademetrio   +10 more
wiley   +1 more source

Removal of innate immune barriers allows efficient transduction of quiescent human hematopoietic stem cells [PDF]

: Quiescent human hematopoietic stem cells (HSC) are ideal targets for gene therapy applications due to their preserved stemness and repopulation capacities; however, they have not been exploited extensively because of their resistance to genetic ...
Unali, Giulia, Benedicenti, Fabrizio, Oo, Adrian, Pais, Giulia, Castiglioni, Ilaria, Spinozzi, Giulio, Kim, Baek, Landau, Nathaniel R, Ferrari, Giuliana, Valeri, Erika, Cuccovillo, Ivan, Abou-Alezz, Monah, Kajaste-Rudnitski, Anna, Behrendt, Rayk, Piras, Francesco, Arévalo, Sergio, Merelli, Ivan, Lidonnici, Maria Rosa, Montini, Eugenio, Lidonnici M. R., Kim B., Valeri E., Landau N. R., Montini E., Abou-Alezz M., Behrendt R., Merelli I., Unali G., Piras F., Oo A., Benedicenti F., Castiglioni I., Cuccovillo I., Spinozzi G., Ferrari G., Kajaste-Rudnitski A., Pais G., Arevalo S.   +37 more
core   +1 more source

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source