Results 31 to 40 of about 1,297,985 (274)

AlphaPeptDeep: a modular deep learning framework to predict peptide properties for proteomics

Nature Communications, 2022
Deep learning (DL) has been frequently used in mass spectrometry-based proteomics but there is still a lot of potential. Here, the authors develop a framework that enables building DL models to predict arbitrary peptide properties with only a few lines ...
Wen-Feng Zeng, Xie-Xuan Zhou, Sander Willems, Constantin Ammar, Maria Wahle, Isabell Bludau, Eugenia Voytik, Maximillian T. Strauss, Matthias Mann   +8 more
doaj   +1 more source

Mechano-transduction: from molecules to tissues. [PDF]

, 2014
External forces play complex roles in cell organization, fate, and homeostasis. Changes in these forces, or how cells respond to them, can result in abnormal embryonic development and diseases in adults.
Dunn, Alexander R, Nelson, W James, Pruitt, Beth L, Weis, William I   +3 more
core   +2 more sources

Ras p21 protein promotes survival and fiber outgrowth of cultured embryonic neurons [PDF]

, 1989
Although evidence obtained with the PC12 cell line has suggested a role for the ras oncogene proteins in the signal transduction of nerve growth factor-mediated fiber outgrowth, little is known about the signal transduction mechanisms involved in the ...
Barde, Y. A., Borasio, Gian Domenico, Heumann, R., John, J., Sendtner, M., Wittinghofer, A.   +5 more
core   +2 more sources

Transduction

Revue de Stomatologie, de Chirurgie Maxillo-faciale et de Chirurgie Orale, 2014
Citation: 'transduction' in the IUPAC Compendium of Chemical Terminology, 3rd ed.; International Union of Pure and Applied Chemistry; 2006. Online version 3.0.1, 2019. 10.1351/goldbook.T06438 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms.
B. Devauchelle, S. Dakpe, C. Neiva, Y. Peltier, P. Toussaint, S. Testelin   +5 more
  +4 more sources

Electrostatic interaction of tumor-targeting adenoviruses with aminoclay acquires enhanced infectivity to tumor cells inside the bladder and has better cytotoxic activity

Drug Delivery, 2018
In a previous report, 3-aminopropyl functionalized magnesium phyllosilicate (aminoclay) improved adenovirus transduction efficiency by shielding the negative surface charges of adenovirus particles.
Soo-Yeon Kim, Whi-An Kwon, Seung-Pil Shin, Ho Kyung Seo, Soo-Jeong Lim, Yuh-Seog Jung, Hyo-Kyung Han, Kyung-Chae Jeong, Sang-Jin Lee   +8 more
doaj   +1 more source

Optomechanical Transductions in Single and Coupled Wheel Resonators

, 2013
In this report, the optomechanical transductions in both single and two side-coupled wheel resonators are investigated. In the single resonator, the optomechanical transduction sensitivity is determined by the optical and mechanical quality factors of ...
Fan, Jiahua, Huang, Chenguang, Zhang, Ruoyu, Zhu, Lin   +3 more
core   +1 more source

Protein Transduction Method for Cerebrovascular Disorders [PDF]

, 2009
Many studies have shown that a motif of 11 consecutive arginines (11R) is one of the most effective protein transduction domains (PTD) for introducing proteins into the cell membrane.
Arimitsu, Seiji, Date, Isao, Ichikawa, Tomotsugu, Matsui, Hideki, Ogawa, Tomoyuki, Ono, Shigeki, Onoda, Keisuke, Sugiu, Kenji, Tokunaga, Koji, Tomizawa, Kazuhito   +9 more
core   +1 more source

Purinergic mechanosensory transduction and visceral pain [PDF]

, 2009
In this review, evidence is presented to support the hypothesis that mechanosensory transduction occurs in tubes and sacs and can initiate visceral pain.
Burnstock, G
core   +3 more sources

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Genome editing of TXNIP in human pluripotent stem cells for the generation of hepatocyte-like cells and insulin-producing islet-like aggregates

Stem Cell Research & Therapy
Background Thioredoxin-interacting protein (TXNIP) plays a role in regulating endoplasmic reticulum (ER) and oxidative stress, which disrupt glucose homeostasis in diabetes. However, the impact of TXNIP deficiency on the differentiation and functionality
Leonardo Traini, Javier Negueruela, Bernat Elvira, Wadsen St-Pierre-Wijckmans, Valerie Vandenbempt, Carlos E. Buss, Ao Li, Israel Pérez-Chávez, Francisco Ribeiro-Costa, Mariana Nunes, Joris Messens, Daria Ezeriņa, David C. Hay, Mayank Bansal, Esteban N. Gurzov   +14 more
doaj   +1 more source