Results 71 to 80 of about 1,297,985 (274)

Pathway to the PiezoElectronic Transduction Logic Device

, 2015
The information age challenges computer technology to process an exponentially increasing computational load on a limited energy budget - a requirement that demands an exponential reduction in energy per operation.
Armstrong, C., Bryce, B. A., Copel, M., Elmegreen, B. G., Gordon, M. S., Haensch, W., Hung, L. -W., Keech, R., Kuroda, M. A., Liu, X. -H., Martyna, G. J, Miyazoe, H., Newns, D. M., Reuter, K. B., Rossnagel, S. M., Schrott, A. G., Shaw, T. M., Shett, S., Solomon, P. M., Theis, T. N., Trolier-McKinstry, S.   +20 more
core   +2 more sources

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source

Current landscape of cystic fibrosis gene therapy

Frontiers in Pharmacology
Cystic fibrosis is a life-threatening disease that is caused by mutations in CFTR, a gene which encodes an ion channel that supports proper function of several epithelial tissues, most critically the lung.
Lindsey W. Plasschaert, Kelvin D. MacDonald, Kelvin D. MacDonald, Jeffrey S. Moffit   +3 more
doaj   +1 more source

Streamable regular transductions

Theoretical Computer Science, 2020
53 ...
Alur, Rajeev, Fisman, Dana, Mamouras, Konstantinos, Raghothaman, Mukund, Stanford, Caleb   +4 more
openaire   +3 more sources

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

Temporality and technical, psychic and collective individuations in the work of Simondon

Trilogía Ciencia Tecnología Sociedad, 2012
temporality and technical, psychic and collective individuations in the work of Simondon. Simondon describes technical artefacts as possessing a tendency towards increasing organisation, in a process of individuation.
Bernard Stiegler
doaj   +1 more source

Why did life emerge? [PDF]

, 2008
Many mechanisms, functions and structures of life have been unraveled. However, the fundamental driving force that propelled chemical evolution and led to life has remained obscure.
Annila A., Annila E., Annila, Arto
core  

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

CRISPR-Cas-Mediated Phage Resistance Enhances Horizontal Gene Transfer by Transduction

mBio, 2018
A powerful contributor to prokaryotic evolution is horizontal gene transfer (HGT) through transformation, conjugation, and transduction, which can be advantageous, neutral, or detrimental to fitness.
Bridget N. J. Watson, Raymond H. J. Staals, Peter C. Fineran   +2 more
doaj   +1 more source

Establishment and Application of Engineered NIH 3T3 Cell Line with Stable Human RAGE Expression

Pharmaceutical Fronts, 2020
Aim NIH3T3 cell line with expression of human receptor for advanced glycation end-products (hRAGE) transduced with lentivirus vectors was used to analyze affinity, biological activity, and/or molecular mechanisms of molecules targeting the hRAGE pathway.
Xinyi Xiao, Hui Chen, Pameila Paerhati, Meiqi Zhou, Zhuoyi Yang, Siyi Bai, Yunsheng Yuan   +6 more
doaj   +1 more source