Results 121 to 130 of about 145,799 (355)

Towards AI-enabled Control for Enhancing Quantum Transduction

open access: yes, 2020
With advent of quantum internet, it becomes crucial to find novel ways to connect distributed quantum testbeds and develop novel technologies and research that extend innovations in managing the qubit performance. Numerous emerging technologies are focused on quantum repeaters and specialized hardware to extend the quantum distance over special-purpose
Metcalf, Mekena   +2 more
openaire   +3 more sources

Indoleamine 2,3‐dioxygenase 1 inhibition reverses cancer‐associated fibroblast‐mediated immunosuppression in high‐grade serous ovarian cancer

open access: yesFEBS Open Bio, EarlyView.
CAF‐mediated immunosuppression in ovarian cancer is driven by IDO1, reducing T‐cell function. Inhibiting IDO1 restores T‐cell proliferation and cytotoxicity, increases cancer cell apoptosis, and may help overcome CAF‐induced immune suppression in high‐grade serous ovarian cancer. Targeting IDO1 may improve antitumor immunity.
Hyewon Lee   +3 more
wiley   +1 more source

E-Ras improves the efficiency of reprogramming by facilitating cell cycle progression through JNK–Sp1 pathway

open access: yesStem Cell Research, 2015
We have previously shown that pluripotent stem cells can be induced from adult somatic cells which were exposed to protein extracts isolated from mouse embryonic stem cells (mESC).
Yoo-Wook Kwon   +6 more
doaj   +1 more source

Overexpression of CDT1 inhibits cell cycle progression at S phase by interacting with the mini‐chromosome maintenance complex and causes DNA damage

open access: yesFEBS Open Bio, EarlyView.
CDT1 is an essential protein for DNA replication licensing that loads the MCM complex, the eukaryotic replicative DNA helicase, onto replication origins. Overexpression of CDT1 induces cell cycle arrest at the S phase. Here we showed CDT1 inhibits the progression of replication forks by interacting with the MCM complex, leading to the stalling and ...
Takashi Tsuyama   +7 more
wiley   +1 more source

Disrupting NtrC function reveals unexpected robustness in a central cell cycle regulatory network

open access: yesmBio
Cell cycle progression relies on coordinated signaling systems that integrate diverse cellular and environmental cues. In Caulobacter and related Alphaproteobacteria, the essential sensor histidine kinase CckA initiates a phosphorelay signaling cascade ...
Hunter North   +4 more
doaj   +1 more source

Enhancement of T Cell Receptor Signaling of Tumor‐infiltrating Lymphocytes by Retrovirally Mediated fyn Gene Transduction [PDF]

open access: hybrid, 1994
Kazuyuki Fujita   +6 more
openalex   +1 more source

Molecular determinants of signal transduction in tropomyosin receptor kinases

open access: yesFEBS Open Bio, EarlyView.
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley   +1 more source

Enhancement from plasmonic-molecular coupling for mass transduction

open access: yes, 2023
The plasmon-mechanical resonators are frequently used in the development of sensors. Active frameworks impose mechanical motion into the lasing dynamics through the use of an optical gain and achieve better sensitivity. Here plasmon-mechanical coupling is demonstrated in a multilayer when a surface plasmon polariton/Fabry-Pérot hybrid mode is excited ...
openaire   +2 more sources

Dietary nitrate and nitrite protect against doxorubicin‐induced cardiac fibrosis and oxidative protein damage in tumor‐bearing mice

open access: yesFEBS Open Bio, EarlyView.
Chemotherapies such as doxorubicin can have toxic effects on healthy cardiovascular/heart tissue. Following up on a doxorubicin toxicity study in mice without tumors where nitrate water was cardioprotective (lessened toxicity), this study with tumor‐bearing mice undergoing doxorubicin treatment showed no negative effect of nitrate and nitrite on drug ...
Rama D. Yammani   +7 more
wiley   +1 more source

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