Results 101 to 110 of about 304,117 (294)

Analysis of HER2 genomic binding in breast cancer cells identifies a global role in direct gene regulation.

PLoS ONE, 2019
HER2 is a transmembrane receptor tyrosine kinase, which plays a key role in breast cancer due to a common genomic amplification. It is used as a marker to stratify patients in the clinic and is targeted by a number of drugs including Trastuzumab and ...
Aisling M Redmond, Soleilmane Omarjee, Igor Chernukhin, Muriel Le Romancer, Jason S Carroll   +4 more
doaj   +1 more source

Signal transduction /

, 2003
Signal Transduction is a well-illustrated, coherent look at cellular signaling processes. Beginning with the basics, it explains how cells respond to external cues, hormones, growth factors, cytokines, cell surfaces, etc., and then shows how these inputs
Tatham, Peter E. R.(Life scientist), Gomperts, B. D., Kramer, Ijsbrand M.   +2 more
core  

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source

pH-responsive virus-drug conjugates for targeted PD-L1 silencing and enhanced cancer immunotherapy

Journal of Nanobiotechnology
Clinical efficacy of virotherapy is often limited by poor transduction and off-target effects. To overcome these hurdles, we engineered a multi-stage, pH-responsive virus-drug conjugate (VDC) for targeted, cancer immunotherapy.
S.-Ja Tseng, Ivan M. Kempson, Yi-Cheng Ho, Pan-Chyr Yang, Zi-Xian Liao   +4 more
doaj   +1 more source

Potential Anti-Inflammatory and Anti-Cancer Properties of Farnesol

Molecules, 2018
Farnesol, an acyclic sesquiterpene alcohol, is predominantly found in essential oils of various plants in nature. It has been reported to exhibit anti-cancer and anti-inflammatory effects, and also alleviate allergic asthma, gliosis, and edema.
Young Yun Jung, Sun Tae Hwang, Gautam Sethi, Lu Fan, Frank Arfuso, Kwang Seok Ahn   +5 more
doaj   +1 more source

Clofarabine Enhances the Transduction Efficiency of Recombinant AAV2 in the Retina

Investigative Ophthalmology & Visual Science
Ribonucleotide reductase inhibitors, a class of antineoplastic agents, were investigated for their ability to enhance recombinant adeno-associated virus serotype 2 (rAAV2) transduction in the mouse retina and their underlying mechanisms.Candidate ribonucleotide reductase inhibitors were screened in ARPE-19 cells to identify concentrations preserving ...
Diao, Yuyao, Xiong, Xuewei, Liu, Jiayan, Teng, Xingbo, Shi, Qi, Jin, Shangli, Lei, Yahui, Ma, Shisi, Liu, Guei-Sheung, Liu, Lian, Yu, Guocheng, Wang, Jiang-Hui, Zhong, Jingxiang, Tu, Leilei   +13 more
openaire   +2 more sources

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Yeast Gcn2 retains activity following humanization of its auto‐phosphorylation region

FEBS Open Bio, EarlyView.
Using Saccharomyces cerevisiae as a model to study Gcn2 activation and regulation is limited by the lack of antibodies detecting phosphorylated Gcn2. To overcome this, we engineered Gcn2‐HsC, a yeast Gcn2 variant recognizable by commercial anti‐human phospho‐GCN2 antibodies.
Reuben A. Anderson, Anja H. Schiemann, Evelyn Sattlegger   +2 more
wiley   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

KDAC6 alters cell morphology and motility through positive and negative modulation of F‐actin distribution

FEBS Open Bio, EarlyView.
KDAC6 has been associated with cell motility and actin structures, but specific domain contributions are not established. The two catalytic domains have differential effects on motility and F‐actin regulation, affecting cortical F‐actin density, motility, stress fibers, and cell spreading.
Taylor V. Joseph, Andrea B. Pham, Kiara E. Bornes, Razan H. Hammad, Chelsea A. Rousseve‐Ross, Thomas M. Huckaba, Terry J. Watt, Tasha B. Toro   +7 more
wiley   +1 more source