Results 81 to 90 of about 304,117 (294)

Analysis of the Effect of Methylation Alterations on Enhancer Activity in Cancer

Guoji laonian yixue zazhi
Objective To analyze and identify the impact of methylation changes on enhancer activity in cancer. Methods Obtain enhancers, transcription factor binding sites, and molecular pathway data from the human enhancer database FANTOM5, methylated DNA binding ...
Yunxiao Xie, Na Ding
doaj   +1 more source

In vitro and in vivo validation of human and goat chondrocyte labeling by green fluorescent protein lentivirus transduction [PDF]

, 2010
We investigated whether human articular chondrocytes can be labeled efficiently and for long-term with a green fluorescent protein (GFP) lentivirus and whether the viral transduction would influence cell proliferation and tissue-forming capacity.
Candrian, Christian, Gianni-Barrera, Roberto, Juelke, Henriette, Martin, Ivan, Jaquiery, Claude, Acharya, Chitrangada, Barbero, Andrea, Miot, Sylvie, Pelttari, Karoliina, Mainil-Varlet, Pierre, Mainil-Varlet P, Acharya C, Barbero A, Pelttari K, Candrian C, Miot S, Martin I, Juelke H, Jaquiery C, Gianni-Barrera R   +19 more
core   +2 more sources

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Development of Adeno-associated viral (AAV) vectors that specifically express in endothelial cells [PDF]

, 2019
Optimization of transduction of Adeno-associated viral (AAV) vectors that specifically express in endothelial cells with an element of a super ...
Esparta González, Olaya
core  

Transcription factor complex formation and chromatin fine structure alterations at the murine c-fms (CSF-1 receptor) locus during maturation of myeloid precursor cells [PDF]

, 2002
Expression of the gene for the macrophage colony stimulating factor receptor (CSF-1R), c-fms, has been viewed as a hallmark of the commitment of multipotent precursor cells to macrophages.
Bonifer, Constanze, Pieter J.M. Leenen, Himes, R, Clarke, D, Himes, Roy, Riggs, A. D., Bonifer, Constanze; id_orcid, Tagoh, H., Tagoh, Hiromi, Hume, David, Himes, R., Tagoh, H, Hume, D., Leenen, PJ, Roy Himes, Clarke, D., Bonifer, C, Leenen, Pieter J M, Constanze Bonifer, David Hume, Riggs, AD, Bonifer, C., Leenen, P. J. M., Arthur D. Riggs, Leenen, Pieter, Clarke, Deborah, Hiromi Tagoh, Deborah Clarke, Riggs, Arthur D, Hume, D   +29 more
core   +1 more source

Enhancer annotation summary statistics.

, 2022
A) Genomic coverage by tissue category. B) Adult brain and astrocyte enhancer annotations had the highest genomic coverage compared to fetal, neurosphere, and ESC-derived enhancer annotations. C) Enhancer number by tissue category.
Alex M. Casella (9427789), Carlo Colantuoni (67660), Seth A. Ament (9427801)   +2 more
core   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Comparative AAV-eGFP Transgene Expression Using Vector Serotypes 1–9, 7m8, and 8b in Human Pluripotent Stem Cells, RPEs, and Human and Rat Cortical Neurons

Stem Cells International, 2019
Recombinant adeno-associated virus (rAAV), produced from a nonpathogenic parvovirus, has become an increasing popular vector for gene therapy applications in human clinical trials. However, transduction and transgene expression of rAAVs can differ across
Thu T. Duong, James Lim, Vidyullatha Vasireddy, Tyler Papp, Hung Nguyen, Lanfranco Leo, Jieyan Pan, Shangzhen Zhou, H. Isaac Chen, Jean Bennett, Jason A. Mills   +10 more
doaj   +1 more source

An egg apparatus-specific enhancer of Arabidopsis, identified by enhancer detection

, 2005
Despite a central role in angiosperm reproduction, few gametophyte-specific genes and promoters have been isolated, particularly for the inaccessible female gametophyte (embryo sac).
Jefferson, R. A., Gagliano, Wendy, Huttner, E., Jefferson, Richard, Huttner, Eric, Yang, W., Moore, J. M., Grossniklaus, Ueli, Gagliano, W. B., Grossniklaus, U., Moore, James, Yang, Wei   +11 more
core   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source