Results 61 to 70 of about 304,117 (294)

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Deficient forward transduction and enhanced reverse transduction in the alpha tectorin C1509G human hearing loss mutation [PDF]

Disease Models & Mechanisms, 2010
SUMMARY Most forms of hearing loss are associated with loss of cochlear outer hair cells (OHCs). OHCs require the tectorial membrane (TM) for stereociliary bundle stimulation (forward transduction) and active feedback (reverse transduction). Alpha tectorin is a protein constituent of the TM and the C1509G mutation in alpha tectorin in
Anping, Xia, Simon S, Gao, Tao, Yuan, Alexander, Osborn, Andreas, Bress, Markus, Pfister, Stephen M, Maricich, Fred A, Pereira, John S, Oghalai   +8 more
openaire   +2 more sources

Cell-specific activity of the modulator region in the human cytomegalovirus major immediate-early gene [PDF]

, 1989
In this paper we demonstrate that modulator sequences upstream of the enhancer of the major immediate-early promoter of human cytomegalovirus exert a differential effect on the level of transcription in a variety of cells and that this region has the ...
Lubon, H, Hennighausen, L, Nelson, J, Reynolds-Kohler, C, Ghazal, Peter, Lockshin, C, Ghazal, P   +6 more
core   +1 more source

The Mediator complex regulates enhancer-promoter interactions [PDF]

, 2023
Enhancer-mediated gene activation generally requires physical proximity between enhancers and their target gene promoters. However, the molecular mechanisms by which interactions between enhancers and promoters are formed are not well understood.
Cao, T. B. Ngoc, Oudelaar, A. Marieke, Ramasamy, Shyam, Cruz, J. Neos, Lidschreiber, Michael, Karpinska, Magdalena A., Velychko, Taras, Aljahani, Abrar, Aljahani, A., Velychko, T. ; https://orcid.org/, Karpinska, M. ; https://orcid.org/, Cruz, J., Ramasamy, S., Lidschreiber, M. ; https://orcid.org/, Oudelaar, A. ; https://orcid.org/, Cao, N.   +15 more
core   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Comprehensive Comparison of Baculoviral and Plasmid Gene Delivery in Mammalian Cells

Viruses
(1) Recombinant protein production in mammalian cells is either based on transient transfection processes, often inefficient and underlying high batch-to-batch variability, or on laborious generation of stable cell lines.
Maria Toth, Manuel Reithofer, Gregory Dutra, Patricia Pereira Aguilar, Astrid Dürauer, Reingard Grabherr   +5 more
doaj   +1 more source

Interaction of G-protein βγ complex with chromatin modulates GPCR-dependent gene regulation. [PDF]

PLoS ONE, 2013
Heterotrimeric G-protein signal transduction initiated by G-protein-coupled receptors (GPCRs) in the plasma membrane is thought to propagate through protein-protein interactions of subunits, Gα and Gβγ in the cytosol. In this study, we show novel nuclear
Anushree Bhatnagar, Hamiyet Unal, Rajaganapathi Jagannathan, Suma Kaveti, Zhong-Hui Duan, Sandro Yong, Amit Vasanji, Michael Kinter, Russell Desnoyer, Sadashiva S Karnik   +9 more
doaj   +1 more source

Filament flexibility enhances power transduction of F-actin bundles [PDF]

The Journal of Chemical Physics, 2019
The dynamic behavior of bundles of actin filaments growing against a loaded obstacle is investigated through a generalized version of the standard multifilament Brownian Ratchet model in which the (de)polymerizing filaments are treated not as rigid rods but as semiflexible discrete wormlike chains with a realistic value of the persistence length.
Alessia Perilli, Carlo Pierleoni, Jean-Paul Ryckaert   +2 more
openaire   +6 more sources

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

Engineered AAV13 Variants with Enhanced Transduction and Confined Spread

Zoological Research
Precise targeting of specific regions within the central nervous system (CNS) is crucial for both scientific research and gene therapy in the context of brain diseases. Adeno-associated virus 13 (AAV13) is known for its restricted diffusion range within the CNS, making it an ideal choice for precise labeling and administration within small brain ...
Luo, Neng-Song, Cai, Yu-Xiang, Han, Zeng-Peng, Sui, Xiao-Kai, Yuan, Wen-Jia, Zhang, Zi-Lian, Guo, Hao-Dong, Wang, Jie, Lin, Kun-Zhang, Xu, Fu-Qiang   +9 more
openaire   +2 more sources