Results 71 to 80 of about 304,117 (294)

Protein transduction: A novel tool for tissue regeneration [PDF]

, 2002
Tissue regeneration in humans is limited and excludes vitals organs like heart and brain. Transformation experiments with oncogenes like T antigen have shown that retrodifferentiation of the respective cells is possible but hard to control. To bypass the
Cardoso, M. C., Cardoso, M. Cristina, Leonhardt, Heinrich, Leonhardt, H., Cardoso, M.C.   +4 more
core   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Purinergic mechanosensory transduction and visceral pain [PDF]

, 2009
In this review, evidence is presented to support the hypothesis that mechanosensory transduction occurs in tubes and sacs and can initiate visceral pain.
Geoffrey Burnstock, Burnstock, G, Burnstock Geoffrey   +2 more
core   +1 more source

Table_1_A novel signature constructed by super-enhancer-related genes for the prediction of prognosis in hepatocellular carcinoma and associated with immune infiltration.docx

, 2023
BackgroundSuper-enhancer (SE) refers to a regulatory element with super transcriptional activity, which can enrich transcription factors and drive gene expression. SE-related genes play an important role in the pathogenesis of malignant tumors, including
Qian Guo (107009), Hongping Yu (188118), Xueyan Wei (4401322), Yingchun Liu (3875), Yanji Jiang (9526885), Qiuling Lin (9526882), Zihan Zhou (4184407), Peiqin Chen (10644699), Meiying Long (13999779), Moqin Qiu (9526879), Jialin Qiu (5081603), Cunli Nong (14590328), Runwei Li (1948711), Qiuping Wen (13999782), Qiongguang Huang (13581310), Xianguo Zhou (9526897)   +15 more
core   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Targeting Adeno-Associated Virus Vectors for Local Delivery to Fractures and Systemic Delivery to the Skeleton

Molecular Therapy: Methods & Clinical Development, 2019
A panel of 18 recombinant adeno-associated virus (rAAV) variants, both natural and engineered, constitutively expressing Cre recombinase under the cytomegalovirus early enhancer/chicken β actin (CAG) promoter, were screened for their ability to transduce
Lucinda R. Lee, Lauren Peacock, Leszek Lisowski, David G. Little, Craig F. Munns, Aaron Schindeler   +5 more
doaj   +1 more source

Transduction of Immortalized Human Hepatocytes with p21 to Enhance Differentiated Phenotypes [PDF]

Cell Transplantation, 2002
We previously constructed an immortal human hepatocyte line NKNT-3 with a simian virus 40 T antigen (SV40T) to develop cell-based biological therapies. p21 is a molecule that regulates the transition from the G 1 phase to the S phase of the cell cycle.
Takemi Kunieda, Naoya Kobayashi M.D., Ph.D., Masakiyo Sakaguchi, Teru Okitsu, Toshinori Totsugawa, Takamasa Watanabe, Toshihisa Matsumura, Masanobu Maruyama, Hirofumi Noguchi, Michihiko Takesue, Norikuni Shibata, Kenji Ohmoto, Toshiyoshi Fujiwara, Shinichiro Yamamoto, Noriaki Tanaka   +14 more
openaire   +3 more sources

DataSheet_1_A novel signature constructed by super-enhancer-related genes for the prediction of prognosis in hepatocellular carcinoma and associated with immune infiltration.docx

, 2023
BackgroundSuper-enhancer (SE) refers to a regulatory element with super transcriptional activity, which can enrich transcription factors and drive gene expression. SE-related genes play an important role in the pathogenesis of malignant tumors, including
Qian Guo (107009), Hongping Yu (188118), Xueyan Wei (4401322), Yingchun Liu (3875), Yanji Jiang (9526885), Qiuling Lin (9526882), Zihan Zhou (4184407), Peiqin Chen (10644699), Meiying Long (13999779), Moqin Qiu (9526879), Jialin Qiu (5081603), Cunli Nong (14590328), Runwei Li (1948711), Qiuping Wen (13999782), Qiongguang Huang (13581310), Xianguo Zhou (9526897)   +15 more
core   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

A role for eIF5A in translational control of stress‐inducible proteins in multiple myeloma cell lines

Molecular Oncology, EarlyView.
Loss of eIF5A rewires thapsigargin‐mediated endoplasmic reticulum stress responses in multiple myeloma cells by selective translation of mRNA transcripts, consequently dampening thapsigargin‐induced unfolded protein response (UPR) activation and shifting the balance from induction of apoptosis toward cell survival and proliferation.
Demi Both, Ingrid A. M. Derks, Raphaël Vanleyssem, Marine Leclercq, Najla El Hachem, Pierre Close, Eric Eldering, Marco Vincent Haselager   +7 more
wiley   +1 more source