Results 31 to 40 of about 7,843,232 (348)
Translating the combination of gene therapy and tissue engineering for treating recessive dystrophic epidermolysis bullosa [PDF]
European Cells & Materials, 2018 The combination of gene therapy and tissue engineering is one of the most promising strategies for the treatment of recessive dystrophic epidermolysis bullosa (RDEB).
A Dakiw Piaceski +8 more
doaj +1 more source
Highly Efficient and Selective CAR-Gene Transfer Using CD4- and CD8-Targeted Lentiviral Vectors
Molecular Therapy: Methods & Clinical Development, 2019 Chimeric antigen receptor (CAR)-modified T cells have revealed promising results in the treatment of cancer, but they still need to overcome various hurdles, including a complicated manufacturing process.
Arezoo Jamali +5 more
doaj +1 more source
HoxA9 binds and represses the Cebpa +8 kb enhancer [PDF]
, 2019 C/EBPα plays a key role in specifying myeloid lineage development. HoxA9 is expressed in myeloid progenitors, with its level diminishing during myeloid maturation, and HOXA9 is over-expressed in a majority of acute myeloid leukemia cases, including those
Aplan, Peter D. +7 more
core +2 more sources
Muscle fiber type-predominant promoter activity in lentiviral-mediated transgenic mouse. [PDF]
PLoS ONE, 2011 Variations in gene promoter/enhancer activity in different muscle fiber types after gene transduction was noticed previously, but poorly analyzed. The murine stem cell virus (MSCV) promoter drives strong, stable gene expression in hematopoietic stem ...
Tomohiro Suga +10 more
doaj +1 more source
Molecular Therapy: Methods & Clinical Development, 2023 Barriers to effective gene therapy for many diseases include the number of modified target cells required to achieve therapeutic outcomes and host immune responses to expressed therapeutic proteins.
Eirini Vamva +14 more
doaj +1 more source
C/EBPβ-1 promotes transformation and chemoresistance in Ewing sarcoma cells. [PDF]
, 2017 CEBPB copy number gain in Ewing sarcoma was previously shown to be associated with worse clinical outcome compared to tumors with normal CEBPB copy number, although the mechanism was not characterized.
Abegglen, Lisa M +12 more
core +1 more source
Journal of Biological Chemistry, 1998 Smad proteins have been identified as mediators of intracellular signal transduction by members of the transforming growth factor-β (TGF-β) superfamily, which affect cell proliferation, differentiation, as well as pattern formation during early ...
L. Jonk +4 more
semanticscholar +1 more source
miR-19a: An Effective Regulator of SOCS3 and Enhancer of JAK-STAT Signalling
PLoS ONE, 2013 Suppressors of cytokine signalling (SOCS) proteins are classic inhibitors of the Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway.
Aideen S. Collins +4 more
semanticscholar +1 more source
Extinction of tyrosine aminotransferase gene activity in somatic cell hybrids involves modification and loss of several essential transcription factors [PDF]
, 1993 Extinction is defined as the loss of cell type-specific gene expression that occurs in somatic cell hybrids derived by fusion of cells with dissimilar phenotypes.
Boshart, Michael +2 more
core +1 more source
MYC Deregulation in Primary Human Cancers
Genes, 2017 MYC regulates a complex biological program by transcriptionally activating and repressing its numerous target genes. As such, MYC is a master regulator of many processes, including cell cycle entry, ribosome biogenesis, and metabolism.
M. Kalkat +8 more
semanticscholar +1 more source