Results 11 to 20 of about 304,117 (294)
Identification of a small molecule for enhancing lentiviral transduction of T cells
Molecular Therapy: Methods & Clinical Development, 2023 Genetic modification of cells using viral vectors has shown huge therapeutic benefit in multiple diseases. However, inefficient transduction contributes to the high cost of these therapies.
Paulina Malach +10 more
doaj +2 more sources
Homeostatic enhancement of sensory transduction [PDF]
Proceedings of the National Academy of Sciences, 2017 Significance How do biological systems ensure robustness of function despite developmental and environmental variation? Although the operation of some systems appears to require precise control over parameter values, we describe how the function of the ear might instead be made robust to parameter perturbation.
Andrew R, Milewski +3 more
openaire +2 more sources
Advanced Science, 2023 Lentiviral vectors (LV) have become the dominant tool for stable gene transfer into lymphocytes including chimeric antigen receptor (CAR) gene delivery to T cells, a major breakthrough in cancer therapy.
Filippos T Charitidis +10 more
doaj +1 more source
IDENTIFICATION OF AN ERG-BOUND ENDOTHELIAL CELL RESTRICTED ENHANCER FOR IL1Α AND IL1Β
, 2022 The progression of atherosclerosis is characterized by plaque formation within the arterial walls that could manifest into coronary artery disease (CAD) leading to myocardial infarction or stroke.
Kadimova, Evilina
core +5 more sources
Viruses, 2022 Due to their ability to trigger strong immune responses, adenoviruses (HAdVs) in general and the serotype5 (HAdV-5) in particular are amongst the most popular viral vectors in research and clinical application.
Astrid Strack +7 more
doaj +1 more source
Scientific Reports, 2022 Transduction of endothelial cells (EC) with a vector that expresses apolipoprotein A-I (APOAI) reduces atherosclerosis in arteries of fat-fed rabbits. However, the effects on atherosclerosis are partial and might be enhanced if APOAI expression could be ...
Meena Sethuraman +6 more
doaj +1 more source
Enhancement of adenoviral transduction with polycationic liposomes in vivo [PDF]
Cancer Gene Therapy, 2000 Although the high transfection efficiency with adenovirus in vitro is well documented, it is still not clear whether adenoviral vectors are effective in vivo in solid tumor models. In our preliminary experiment, transduction of tumor tissue was limited to just around the injection site after intratumoral injection of the adenoviral vector.
S G, Lee +8 more
openaire +2 more sources
Approaches to enhancing the retroviral transduction of human synoviocytes [PDF]
Arthritis Research & Therapy, 2001 This report concerns a clinical trial for rheumatoid arthritis (RA), approved by the US National Institutes of Health and the Food and Drug Administration. An amphotropic retrovirus (MFG-IRAP) was used ex vivo to transfer a cDNA encoding human interleukin-1 receptor antagonist (IL-1Ra) to synovium.
M A, Del Vecchio +4 more
openaire +2 more sources
A Very Strong Enhancer Is Located Upstream of an Immediate Early Gene of Human Cytomegalovirus [PDF]
, 1985 A strong transcription enhancer was identified in the genomic DNA (235 kb) of human cytomegalovirus (HCMV), a ubiquitous and severe pathogen of the herpesvirus group.
Boshart, Michael +5 more
core +1 more source
Co-transduction of dual-adeno-associated virus vectors in the neonatal and adult mouse utricles
Frontiers in Molecular Neuroscience, 2022 Adeno-associated virus (AAV)-mediated gene transfer is an efficient method of gene over-expression in the vestibular end organs. However, AAV has limited usefulness for delivering a large gene, or multiple genes, due to its small packaging capacity (<
Zhong-Rui Chen +19 more
doaj +1 more source