Results 11 to 20 of about 83,780 (258)
Frontiers in Immunology, 2023 Chimeric antigen receptor (CAR)-T cell therapy is a groundbreaking immunotherapy for cancer. However, the intricate and costly manufacturing process remains a hurdle.
Lena Rauch-Wirth +13 more
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Homeostatic enhancement of sensory transduction [PDF]
Proceedings of the National Academy of Sciences, 2017 Significance How do biological systems ensure robustness of function despite developmental and environmental variation? Although the operation of some systems appears to require precise control over parameter values, we describe how the function of the ear might instead be made robust to parameter perturbation.
Andrew R, Milewski +3 more
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Advanced Science, 2023 Lentiviral vectors (LV) have become the dominant tool for stable gene transfer into lymphocytes including chimeric antigen receptor (CAR) gene delivery to T cells, a major breakthrough in cancer therapy.
Filippos T Charitidis +10 more
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Viruses, 2022 Due to their ability to trigger strong immune responses, adenoviruses (HAdVs) in general and the serotype5 (HAdV-5) in particular are amongst the most popular viral vectors in research and clinical application.
Astrid Strack +7 more
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Scientific Reports, 2022 Transduction of endothelial cells (EC) with a vector that expresses apolipoprotein A-I (APOAI) reduces atherosclerosis in arteries of fat-fed rabbits. However, the effects on atherosclerosis are partial and might be enhanced if APOAI expression could be ...
Meena Sethuraman +6 more
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Enhancement of adenoviral transduction with polycationic liposomes in vivo [PDF]
Cancer Gene Therapy, 2000 Although the high transfection efficiency with adenovirus in vitro is well documented, it is still not clear whether adenoviral vectors are effective in vivo in solid tumor models. In our preliminary experiment, transduction of tumor tissue was limited to just around the injection site after intratumoral injection of the adenoviral vector.
S G, Lee +8 more
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Approaches to enhancing the retroviral transduction of human synoviocytes [PDF]
Arthritis Research & Therapy, 2001 This report concerns a clinical trial for rheumatoid arthritis (RA), approved by the US National Institutes of Health and the Food and Drug Administration. An amphotropic retrovirus (MFG-IRAP) was used ex vivo to transfer a cDNA encoding human interleukin-1 receptor antagonist (IL-1Ra) to synovium.
M A, Del Vecchio +4 more
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Co-transduction of dual-adeno-associated virus vectors in the neonatal and adult mouse utricles
Frontiers in Molecular Neuroscience, 2022 Adeno-associated virus (AAV)-mediated gene transfer is an efficient method of gene over-expression in the vestibular end organs. However, AAV has limited usefulness for delivering a large gene, or multiple genes, due to its small packaging capacity (<
Zhong-Rui Chen +19 more
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Tetrameric architecture of an active phenol-bound form of the AAA+ transcriptional regulator DmpR
Nature Communications, 2020 DmpR is a bacterial enhancer binding protein from the AAA+ family of ATPases that binds aromatic compounds and controls the transcription of genes involved in the degradation of toxic pollutants.
Kwang-Hyun Park +11 more
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Molecular Therapy: Methods & Clinical Development, 2020 Hematopoietic stem cell gene therapy is a promising approach for treating disorders of the hematopoietic system. Identifying combinations of cis-regulatory elements that do not impede packaging or transduction efficiency when included in lentiviral ...
Richard A. Morgan +14 more
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