Results 31 to 40 of about 289,359 (292)
Co-transduction of dual-adeno-associated virus vectors in the neonatal and adult mouse utricles
Frontiers in Molecular Neuroscience, 2022 Adeno-associated virus (AAV)-mediated gene transfer is an efficient method of gene over-expression in the vestibular end organs. However, AAV has limited usefulness for delivering a large gene, or multiple genes, due to its small packaging capacity (<
Zhong-Rui Chen +19 more
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The strong enhancer element in the immediate early region of the human cytomegalovirus genome [PDF]
, 1985 The human cytomegalovirus (HCMV), a member of the herpesvirus group, was found to possess a strong transcription enhancer in the immediate early gene region. Co-transfection of enhancerless SV40 DNA with randomly fragmented HCMV DNA yielded two SV40-
Boshart, Michael +9 more
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AdelmanLab/Enhancer-Annotation: CoGENT
, 2022 Connecting Genes to Enhancers with Nascent Transcriptomics Scripts developed by Andrew Field for the purpose of filtering and annotating enhancers peaks generated with dREG. dREG peaks are filtered by read count, p-value, and peak score with dRIP_filt.R.
arfield1
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STCDB: Signal Transduction Classification Database [PDF]
, 2003 Chen M, Lin S, Hofestädt R. STCDB: Signal Transduction Classification Database. Nucleic Acids Research. 2004;32(90001):D456-D458.The Signal Transduction Classification Database (STCDB) is a database of information relative to the classification of signal
Chen, Ming +5 more
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Tetrameric architecture of an active phenol-bound form of the AAA+ transcriptional regulator DmpR
Nature Communications, 2020 DmpR is a bacterial enhancer binding protein from the AAA+ family of ATPases that binds aromatic compounds and controls the transcription of genes involved in the degradation of toxic pollutants.
Kwang-Hyun Park +11 more
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Molecular Therapy: Methods & Clinical Development, 2020 Hematopoietic stem cell gene therapy is a promising approach for treating disorders of the hematopoietic system. Identifying combinations of cis-regulatory elements that do not impede packaging or transduction efficiency when included in lentiviral ...
Richard A. Morgan +14 more
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Molecular Therapy: Methods & Clinical Development, 2021 Adoptive T cell therapy utilizing tumor-specific autologous T cells has shown promising results for cancer treatment. However, the limited numbers of autologous tumor-associated antigen (TAA)-specific T cells and the functional aberrancies, due to ...
Vania Lo Presti +7 more
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Fusogenic effects of murine retroviruses and cationic enhancers of transduction [PDF]
Cancer Gene Therapy, 2000 The maturation of retrovirus particles involves proteolytic cleavage of the envelope glycoprotein transmembrane component, resulting in conversion of the virus particle to a fusogenic or infectious state. Susceptible murine cells exposed to virus-containing supernatants from ecotropic retroviral helper cells occasionally fused to neighboring cells ...
G, Xu +3 more
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A novel two-component signal transduction system in propionibacterium acnes and its association with a putative extracellular signalling peptide [PDF]
, 2011 Propionibacterium acnes, a resident micro-organism of human skin, is thought to be involved in the development of inflammatory acne, which is an exclusive human disease affecting more than 80% of the whole population. Quorum sensing is the regulation of
Guan, Shuang
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Reactive oxygen species: friends and foes of signal transduction. [PDF]
, 2012 The maintenance of highly regulated mechanisms to control intracellular levels of reactive oxygen species (ROS) is essential for normal cellular homeostasis.
Retta SF +5 more
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