Results 31 to 40 of about 304,117 (294)

Highly Efficient and Selective CAR-Gene Transfer Using CD4- and CD8-Targeted Lentiviral Vectors

Molecular Therapy: Methods & Clinical Development, 2019
Chimeric antigen receptor (CAR)-modified T cells have revealed promising results in the treatment of cancer, but they still need to overcome various hurdles, including a complicated manufacturing process.
Arezoo Jamali, Laura Kapitza, Thomas Schaser, Ian C.D. Johnston, Christian J. Buchholz, Jessica Hartmann   +5 more
doaj   +1 more source

A novel Nodal enhancer dependent on pluripotency factors and Smad2/3 signaling conditions a regulatory switch during epiblast maturation [PDF]

, 2014
During early development, modulations in the expression of Nodal, a TGFβ family member, determine the specification of embryonic and extra-embryonic cell identities.
Jérôme Collignon (34631), Francina Langa (49327), Jérôme Collignon, Ataaillah Benhaddou (588226), Ataaillah Benhaddou, Costis Papanayotou, Valérie Mezger (588227), Délara Sabéran-Djoneidi (588228), Collignon, Jérôme, Aitana Perea-Gomez, Délara Sabéran-Djoneidi, Aitana Perea-Gomez (34627), Anne Camus (246751), Perea-Gomez, Aitana, Jouneau, Alice, Camus, Anne, Langa, Francina, Benhaddou, Ataaillah, Francina Langa, Sascha Ott, Anne Camus, Sabéran-Djoneidi, Délara, Alice Jouneau, Papanayotou, Costis, Costis Papanayotou (83558), Sascha Ott (192042), Alice Jouneau (328085), Ott, Sascha, Mezger, Valérie, Valérie Mezger, Ott Sascha, Perea-Gomez Aitana, Collignon Jérôme, Langa Francina, Mezger Valérie, Sabéran-Djoneidi Délara, Benhaddou Ataaillah, Camus Anne, Papanayotou Costis, Jouneau Alice   +39 more
core   +1 more source

Translating the combination of gene therapy and tissue engineering for treating recessive dystrophic epidermolysis bullosa [PDF]

European Cells & Materials, 2018
The combination of gene therapy and tissue engineering is one of the most promising strategies for the treatment of recessive dystrophic epidermolysis bullosa (RDEB).
A Dakiw Piaceski, D Larouche, K Ghani, F Bisson, S Cortez Ghio, S Larochelle, VJ Moulin, M Caruso, L Germain   +8 more
doaj   +1 more source

Infectivity enhancement for adenoviral transduction of canine osteosarcoma cells [PDF]

Gene Therapy, 2005
The full realization of conditionally replicative adenoviruses (CRAds) for cancer therapy has been hampered by the limited knowledge of CRAd function in vivo and particularly in an immunocompetent host. To address this issue, we previously proposed a canine adenovirus type 2 (CAV2)-based CRAd for clinical evaluation in canine patients with osteosarcoma
L P, Le, A A, Rivera, J N, Glasgow, V V, Ternovoi, H, Wu, M, Wang, B F, Smith, G P, Siegal, D T, Curiel   +8 more
openaire   +2 more sources

Muscle fiber type-predominant promoter activity in lentiviral-mediated transgenic mouse. [PDF]

PLoS ONE, 2011
Variations in gene promoter/enhancer activity in different muscle fiber types after gene transduction was noticed previously, but poorly analyzed. The murine stem cell virus (MSCV) promoter drives strong, stable gene expression in hematopoietic stem ...
Tomohiro Suga, En Kimura, Yuka Morioka, Masahito Ikawa, Sheng Li, Katsuhisa Uchino, Yuji Uchida, Satoshi Yamashita, Yasushi Maeda, Jeffrey S Chamberlain, Makoto Uchino   +10 more
doaj   +1 more source

A lentiviral vector B cell gene therapy platform for the delivery of the anti-HIV-1 eCD4-Ig-knob-in-hole-reversed immunoadhesin

Molecular Therapy: Methods & Clinical Development, 2023
Barriers to effective gene therapy for many diseases include the number of modified target cells required to achieve therapeutic outcomes and host immune responses to expressed therapeutic proteins.
Eirini Vamva, Stosh Ozog, Daniel P. Leaman, Rene Yu-Hong Cheng, Nicholas J. Irons, Andee Ott, Claire Stoffers, Iram Khan, Geraldine K.E. Goebrecht, Matthew R. Gardner, Michael Farzan, David J. Rawlings, Michael B. Zwick, Richard G. James, Bruce E. Torbett   +14 more
doaj   +1 more source

Enhancing transduction of the liver by adeno-associated viral vectors [PDF]

Gene Therapy, 2008
A number of distinct factors acting at different stages of the adeno-associated virus vector (AAV)-mediated gene transfer process were found to influence murine hepatocyte transduction. Foremost among these was the viral capsid protein. Self-complementary (sc) AAV pseudotyped with capsid from serotype 8 or rh.10 mediated fourfold greater hepatocyte ...
Nathwani, A. C., Cochrane, M., McIntosh, J., Ng, C. Y. C., Zhou, J., Gray, J. T., Davidoff, A. M.   +6 more
openaire   +5 more sources

Optimization of lentiviral delivery of barcoded anti-CD20 chimeric antigen receptors into rhesus macaque and human natural killer cells

Molecular Therapy: Methods & Clinical Development
Natural killer (NK) cells are pivotal in immunosurveillance and hold great potential for immunotherapy due to their ability to target malignant cells. Their low risk of causing graft-versus-host disease (GvHD) post-allogenic transplantation underscores ...
Taha B. Hayal, Aman A. Mulla, David S.J. Allan, Brynn B. Duncan, Saanika Joshi, So Gun Hong, Rafet Basar, Katayoun Rezvani, Richard W. Childs, Chuanfeng Wu, Cynthia E. Dunbar   +10 more
doaj   +1 more source

Sex significantly influences transduction of murine liver by recombinant adeno-associated viral vectors through an androgen-dependent pathway. [PDF]

, 2003
A systematic evaluation of the influence of sex on transduction by recombinant adeno-associated viral vector (rAAV) indicated that transgene expression after liver-targeted delivery of vector particles was between 5- to 13-fold higher in male mice ...
Spence, Y, Ng, CYC, Nathwani, AC, Davidoff, AM, Zhou, J   +4 more
core  

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source