Results 21 to 30 of about 289,359 (292)
Homeostatic enhancement of sensory transduction [PDF]
Proceedings of the National Academy of Sciences, 2017 Significance How do biological systems ensure robustness of function despite developmental and environmental variation? Although the operation of some systems appears to require precise control over parameter values, we describe how the function of the ear might instead be made robust to parameter perturbation.
Andrew R, Milewski +3 more
openaire +2 more sources
Identification of a small molecule for enhancing lentiviral transduction of T cells
Molecular Therapy: Methods & Clinical Development, 2023 Genetic modification of cells using viral vectors has shown huge therapeutic benefit in multiple diseases. However, inefficient transduction contributes to the high cost of these therapies.
Paulina Malach +10 more
doaj +1 more source
Advanced Science, 2023 Lentiviral vectors (LV) have become the dominant tool for stable gene transfer into lymphocytes including chimeric antigen receptor (CAR) gene delivery to T cells, a major breakthrough in cancer therapy.
Filippos T Charitidis +10 more
doaj +1 more source
Approaches to enhancing the retroviral transduction of human synoviocytes [PDF]
Arthritis Research & Therapy, 2001 This report concerns a clinical trial for rheumatoid arthritis (RA), approved by the US National Institutes of Health and the Food and Drug Administration. An amphotropic retrovirus (MFG-IRAP) was used ex vivo to transfer a cDNA encoding human interleukin-1 receptor antagonist (IL-1Ra) to synovium.
M A, Del Vecchio +4 more
openaire +2 more sources
Viruses, 2022 Due to their ability to trigger strong immune responses, adenoviruses (HAdVs) in general and the serotype5 (HAdV-5) in particular are amongst the most popular viral vectors in research and clinical application.
Astrid Strack +7 more
doaj +1 more source
Scientific Reports, 2022 Transduction of endothelial cells (EC) with a vector that expresses apolipoprotein A-I (APOAI) reduces atherosclerosis in arteries of fat-fed rabbits. However, the effects on atherosclerosis are partial and might be enhanced if APOAI expression could be ...
Meena Sethuraman +6 more
doaj +1 more source
Enhancement of adenoviral transduction with polycationic liposomes in vivo [PDF]
Cancer Gene Therapy, 2000 Although the high transfection efficiency with adenovirus in vitro is well documented, it is still not clear whether adenoviral vectors are effective in vivo in solid tumor models. In our preliminary experiment, transduction of tumor tissue was limited to just around the injection site after intratumoral injection of the adenoviral vector.
S G, Lee +8 more
openaire +2 more sources
A Very Strong Enhancer Is Located Upstream of an Immediate Early Gene of Human Cytomegalovirus [PDF]
, 1985 A strong transcription enhancer was identified in the genomic DNA (235 kb) of human cytomegalovirus (HCMV), a ubiquitous and severe pathogen of the herpesvirus group.
Boshart, Michael +5 more
core +1 more source
Multiple sequence-specific transcription factors modulate cytomegalovirus enhancer activity in vitro [PDF]
, 1988 The possibility of DNA-binding proteins interacting in vitro with the polymerase II transcriptional machinery was explored by using a competition assay with individual target sequences for enhancer-binding factors.
Lubon, H +5 more
core +1 more source
bianlab-hub/Chen_Sci_Adv_2022: enhancer
, 2022 Aberrations in tissue-specific enhancers underlie many developmental defects. Disrupting a noncoding region distal from the human SOX9 gene causes the Pierre Robin sequence (PRS) characterized by the undersized lower jaw.
bianlab-hub
core +1 more source