In Vivo Evaluation of Miconazole-Nitrate-Loaded Transethosomal Gel Using a Rat Model Infected with Candida albicans [PDF]
PharmaceuticalsMiconazole nitrate (MCNR), an antifungal drug, is used to treat superficial infections. The objective of the current study was to assess the antifungal effectiveness of MCNR-loaded transethosomal gel (MNTG) against Candida albicans in an in vivo rat ...
Zara Asghar +6 more
doaj +4 more sources
Transethosomal gels as carriers for the transdermal delivery of colchicine: statistical optimization, characterization, and ex vivo evaluation [PDF]
Drug Design, Development and Therapy, 2018 Ibrahim M Abdulbaqi, Yusrida Darwis, Reem Abou Assi, Nurzalina Abdul Karim Khan School of Pharmaceutical Sciences, Universiti Sains Malaysia, Minden, Penang, Malaysia Introduction: Colchicine is used for the treatment of gout, pseudo-gout, familial ...
Abdulbaqi IM +3 more
doaj +6 more sources
Transethosomal gel for enhancing transdermal delivery of natural therapeutics [PDF]
NanomedicineTransethosomes, a fusion of transferosomes and ethosomes, combine the advantageous attributes of both vesicular systems to enhance deformability and skin permeation. While skin delivery is effective for drug transport, overcoming the skin barrier remains a significant challenge, particularly for plant-based products with poor permeability ...
Soki Daeme Malang, Alakh N Sahu
exaly +4 more sources
Rutin-Loaded Transethosomal Gel for Topical Application: A Comprehensive Analysis of Skin Permeation and Antimicrobial Efficacy [PDF]
ACS OmegaThis study conducts a systematic investigation of the creation and optimization of a rutin-loaded transethosome intended for topical use. The formulation's characteristics were thoroughly assessed for vesicle size (160.45 ± 1.98 nm), polydispersity index (0.235 ± 0.067), and zeta potential (-22.89 mV), with an entrapment efficiency and drug loading of ...
Mohammed F. Aldawsari +2 more
doaj +4 more sources
Formulation Development, Optimization by Box–Behnken Design, and In Vitro and Ex Vivo Characterization of Hexatriacontane-Loaded Transethosomal Gel for Antimicrobial Treatment for Skin Infections [PDF]
Gels, 2023 There are many different infections and factors that can lead to skin illnesses, but bacteria and fungi are the most frequent. The goal of this study was to develop a hexatriacontane-loaded transethosome (HTC-TES) for treating skin conditions caused by ...
Alhussain H. Aodah +10 more
doaj +2 more sources
Numerical Optimization of Prednisolone–Tacrolimus Loaded Ultraflexible Transethosomes for Transdermal Delivery Enhancement; Box–Behnken Design, Evaluation, Optimization, and Pharmacokinetic Study [PDF]
Gels, 2023 The aim of the present study is to formulate highly permeable carriers (i.e., transethosomes) for enhancing the delivery of prednisolone combined with tacrolimus for both topical and systemic pathological conditions. A Box–Behnken experimental design was
Munerah M. Alfadhel +3 more
doaj +2 more sources
BIFONAZOLE LOADED TRANSETHOSOMAL GEL: FORMULATION AND OPTIMIZATION BY BOX BEHNKEN DESIGN [PDF]
Bulletin of Pharmaceutical Sciences. Assiut University, 2023 This study was intended to develop and optimize the transethosomal gel of Bifonazole for the treatment of fungal infections. For the optimization purpose, Box-Behnken Design was used, and the concentration of soya lecithin, ethanol and sodium cholate ...
Kshema ., Sandhya Vasanth, Sneh Priya
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Transdermal Delivery of Telmisartan: Formulation, in vitro, ex vivo, Iontophoretic Permeation Enhancement and Comparative Pharmacokinetic Study in Rats [PDF]
Drug Design, Development and Therapy, 2021 Mahmoud Teaima,1 Rehab Abdelmonem,2 Yomna A Adel,3 Mohamed A El-Nabarawi,1 Tayseer M El-Nawawy3 1Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University, Cairo, Egypt; 2Department of Industrial Pharmacy, College of ...
Teaima M +4 more
doaj +2 more sources
Eugenol: An Insight Into the Anticancer Perspective and Pharmacological Aspects. [PDF]
Food Sci NutrEugenol (Eug), a volatile phenolic bioactive compound with formula of C10H12O2 have been reported with anticancer, antidiabetic, cardio‐ and pulmonary protective role. Moreover, it has the ability to improve gut health and prevent neurodegenerative disorders. According to WHO, the safe dose of Eug is 2.5 mg/kg for consumption.
Noman AM +13 more
europepmc +2 more sources
DESIGN AND CHARACTERIZATION OF A FILM-FORMING GEL CONTAINING DOMPERIDONE-LOADED TRANSETHOSOMES FOR TRANSDERMAL DELIVERY [PDF]
Bulletin of Pharmaceutical Sciences. Assiut University, 2023 This research aimed at formulating transethosomal film-forming gel (TG) of domperidone- an antiemetic and anti-sickness drug. The prepared transethosomes (TE) were optimized and the vesicle size, PDI and %EE of the optimized TE was 15.1nm, 0.387 and 73 ...
Samantha Sequira, Sneh Priya
doaj +2 more sources