Formulation and Characterization of Hesperidin-Loaded Transethosomal Gel for Dermal Delivery to Enhance Antibacterial Activity: Comprehension of In Vitro, Ex Vivo, and Dermatokinetic Analysis [PDF]
Gels, 2023 In this study, hesperidin was loaded into a transethosome and was developed employing the rotary evaporator method. The formulation was optimized using the Box–Behnken design (BBD).
Perwez Alam +2 more
exaly +4 more sources
Preparation and Characterization of Transethosome Formulation for the Enhanced Delivery of Sinapic Acid [PDF]
Pharmaceutics, 2023 Sinapic acid (SA) is a bioactive phenolic acid; its diverse properties are its anti-inflammatory, antioxidant, anticancer, and antibacterial activities. The bioactive compound SA is poorly soluble in water.
Yousef A Bin Jardan +2 more
exaly +4 more sources
Ethosomes and Transethosomes as Cutaneous Delivery Systems for Quercetin: A Preliminary Study on Melanoma Cells [PDF]
Pharmaceutics, 2022 The present study is aimed to design ethosomes and transethosomes for topical administration of quercetin. To overcome quercetin low bioavailability, scarce solubility and poor permeability that hamper its pharmaceutical use, the drug was loaded in ...
Francesca Ferrara +2 more
exaly +4 more sources
Formulation Development, Optimization by Box–Behnken Design, and In Vitro and Ex Vivo Characterization of Hexatriacontane-Loaded Transethosomal Gel for Antimicrobial Treatment for Skin Infections [PDF]
Gels, 2023 There are many different infections and factors that can lead to skin illnesses, but bacteria and fungi are the most frequent. The goal of this study was to develop a hexatriacontane-loaded transethosome (HTC-TES) for treating skin conditions caused by ...
Alhussain H. Aodah +10 more
doaj +2 more sources
Nanoparticulate System for the Transdermal Delivery of Catechin as an Antihypercholesterol: In Vitro and In Vivo Evaluations [PDF]
Pharmaceuticals, 2022 Gambir (Uncaria gambir, Roxb.) contains catechins that is often empirically used to treat various diseases. Catechins can reduce cholesterol levels by inhibiting coenzyme HMG-CoA reductase that plays a role in cholesterol metabolism.
Soraya Ratnawulan Mita +6 more
doaj +2 more sources
“Plurethosome” as Vesicular System for Cutaneous Administration of Mangiferin: Formulative Study and 3D Skin Tissue Evaluation [PDF]
Pharmaceutics, 2021 Human skin is dramatically exposed to toxic pollutants such as ozone. To counteract the skin disorders induced by the air pollution, natural antioxidants such as mangiferin could be employed.
Maddalena Sguizzato +10 more
doaj +2 more sources
Nanotransethosomes for enhanced transdermal delivery of mangiferin against rheumatoid arthritis: formulation, characterization, invivo pharmacokinetic and pharmacodynamic evaluation [PDF]
Drug Delivery, 2023 The present research study limns the preparation of MNF loaded transethosomes (MNF-TE) to improve MNF solubility, bioavailability and permeation through skin layers for transdermal delivery.
Syeda Nashvia Adin +5 more
doaj +2 more sources
Development and Optimization of Erythromycin Loaded Transethosomes Cinnamon Oil Based Emulgel for Antimicrobial Efficiency [PDF]
Gels, 2023 Erythromycin (EM) is a macrolide antibiotic that is frequently used to treat skin bacterial infections. It has a short half-life (1–1.5 h), instability in stomach pH, and a low oral bioavailability.
Marwa H. Abdallah +7 more
doaj +2 more sources
Enhancing transdermal delivery of retinyl acetate via transethosomes with emphasis on the impact of edge activators on penetration, safety, and efficacy [PDF]
Scientific ReportsTransethosomes are advanced lipid-based nanocarriers engineered to improve the transdermal delivery of therapeutic agents by combining phospholipids, ethanol, and edge activators (EAs), resulting in enhanced membrane fluidity, deformability, and skin ...
Nichaporn Wongsirojkul +7 more
doaj +2 more sources
Ethosomes and Transethosomes for Mangiferin Transdermal Delivery [PDF]
Antioxidants, 2021 Mangiferin is a natural glucosyl xanthone with antioxidant and anti-inflammatory activity, making it suitable for protection against cutaneous diseases.
Maddalena Sguizzato +10 more
doaj +2 more sources