Results 231 to 240 of about 733,470 (308)

Circadian Clock Regulates Epidermal Endocrine System in Homeostatic Skin Pigmentation. [PDF]

Exp Dermatol
Zhu A, Yang L, Lai S, Yang F, Tsuruta D, Katayama I.   +5 more
europepmc   +1 more source

HNRNPU K181 Lactylation Drives Cervical Cancer Growth by Upregulating PHGDH and Reprogramming Serine Metabolism

Advanced Science, EarlyView.
Lactate in cervical cancer induces HNRNPU K181 lactylation, opposed by NAA50‐mediated acetylation and suppressed by Pazopanib. This lactylation enhances HNRNPU binding to PHGDH pre‐mRNA exon 1, maintaining exon 1‐containing transcripts and mRNA stability, thereby activating serine metabolism.
Chang Zhang, Qingfei Meng, Hui Jiao, Huixin Liu, Xiangchao Wang, Honglan Zhou, Yishu Wang   +6 more
wiley   +1 more source

Compact Cas12f enables genome editing in avian cells. [PDF]

Poult Sci
Han Y, Woo SJ, Choi HJ, Han JY.
europepmc   +1 more source

Molecular Glue cc‐885 Inhibits VHL‐Deficient Clear Cell Renal Cell Carcinoma via ETS1 Degradation

Advanced Science, EarlyView.
VHL‐deficient kidney cancer lacks effective treatments. This study reveals that the molecular glue degrader cc‐885 hijacks the cellular recycling system to selectively destroy the oncogenic protein ETS1, effectively killing VHL‐mutant tumors. Combining CC‐885 with the approved drug belzutifan achieves powerful synergy, offering a promising new ...
Taowei Yang, Qihao Li, Kun Ye, Kezhi Liu, Mi Zhou, Minyu Chen, Lican Liao, Kangbo Huang, Zhu Wang, Qiong Deng, Jieyan Wang, Meiyu Jin, Xu Chen, Hui Liang, Jiaxing Zhang, Junhang Luo   +15 more
wiley   +1 more source

Erratum: [Corrigendum] TERT promoter regulating melittin expression induces apoptosis and G₀/G₁ cell cycle arrest in esophageal carcinoma cells. [PDF]

Oncol Lett
Zhou C, Ma J, Lu Y, Zhao W, Xu B, Lin J, Ma Y, Tian Y, Zhang Q, Wang W, Yan W, Jiao P.   +11 more
europepmc   +1 more source

TSPYL5 Promotes Triple‐Negative Breast Cancer Metastasis by Antagonizing USP10‐Mediated PTEN Stabilization to Unleash a ZEB1‐Dependent EMT Program

Advanced Science, EarlyView.
The hyperactivation of PI3K/AKT signaling in PTEN wild‐type triple‐negative breast cancer represents a clinical paradox. We delineate a novel post‐translational regulatory axis wherein the oncogene TSPYL5 competitively antagonizes the deubiquitinase USP10.
Jiaying Shi, Ming Yi, Shengyu Xie, Zhaokun Wang, Xinyue Zhang, Yangwei Zhang, Rui Tang, Yuan Yang, Yunqiang Liu   +8 more
wiley   +1 more source

Meta-Learning as a Promising Strategy for Lipid Nanoparticle Optimization and Ionizable Lipid Discovery. [PDF]

Nano Lett
Sieber-Schäfer F, Hagedorn L, Reger L, Möbius K, Winkeljann B, Merkel OM.   +5 more
europepmc   +1 more source

Qualification of a quantitative stability indicating potency assay for mRNA-LNP vaccine candidates. [PDF]

Gates Open Res
Bzami A, Estrada M, Schofield T, White JA.   +3 more
europepmc   +1 more source

Base editing and nanoparticle transfection of airway cell types essential for treatment of cystic fibrosis. [PDF]

JCI Insight
Kavanagh EW, Joynt AT, Pion AR, Eastman AC, Parr AI, Starego KL, Jain M, Shannon SR, Yoo EJ, Newby GA, Tzeng SY, Sharma N, Green JJ, Cutting GR.   +13 more
europepmc   +1 more source

Duck plague virus US2 promotes p62-mediated autophagic degradation of RIG-I to suppress antiviral signaling. [PDF]

Poult Sci
Hao Y, Xiong M, Wang M, Cheng A.
europepmc   +1 more source