Results 241 to 250 of about 968,391 (388)

Strategies to Improve the Lipophilicity of Hydrophilic Macromolecular Drugs

Advanced Healthcare Materials, EarlyView.
Hydrophilic macromolecular drugs can be successfully lipidized by covalent attachment of lipids, by hydrophobic ion pairing with negatively or positively charged surfactants, and by dry or wet reverse micelle formation. Lipophilicity enhancement of hydrophilic macromolecules has several benefits including stability and bioavailability improvement ...
Sera Lindner, Stefan Keim, Soheil Haddadzadegan, Odile Fernandez Romero, Katrin Zöller, Gabriel Stern, Ilaria Cesi, Krum Kafedjiiski, Andreas Bernkop‐Schnürch   +8 more
wiley   +1 more source

Spleen selective enhancement of transfection activities of plasmid DNA driven by octaarginine and an ionizable lipid and its implications for cancer immunization

, 2019
Seigo Kimura, Ikramy A. Khalil, Yaser Hosny Ali Elewa, Hideyoshi Harashima   +3 more
openalex   +2 more sources

Gene transfection with human hepatocyte growth factor complementary DNA plasmids attenuates cardiac remodeling after acute myocardial infarction in goat hearts implanted with ventricular assist devices [PDF]

, 2005
Yukitoshi Shirakawa, Yoshiki Sawa, Yoshiaki Takewa, Eisuke Tatsumi, Yasufumi Kaneda, Yoshiyuki Taenaka, Hikaru Matsuda   +6 more
openalex   +1 more source

Photosensitizing Lipid Nanoparticles for Ferroptosis‐Enhanced Photodynamic Cancer Therapy via GPX4 Silencing

Advanced Healthcare Materials, EarlyView.
Photosensitizing lipid nanoparticles (PLNPs) are engineered by incorporating cholesterol–PEG–pheophorbide a into MC3‐based LNPs and encapsulating GPX4‐targeting siRNA. Upon light activation, PLNPs generate reactive oxygen species (ROS) while silencing GPX4 to induce ferroptosis.
Ga‐Hyun Bae, Seungyong Shin, Joo Dong Park, Eun‐Young Koh, Seunghyo Ko, Jieun Han, Chun Gown Park, Dong‐Hyun Kim, Kun Na, Wooram Park   +9 more
wiley   +1 more source

Establishing Reagent Testing Platforms for Functional Analyses in Sunflower. [PDF]

Plants (Basel)
Nasti RA, Kenderski CS, Chanchani A, Sharma A, Blackman BK.   +4 more
europepmc   +1 more source

Evaluating the Antiviral Efficacy of Encapsulated PKC Inhibitor BIM‐I against influenza A Virus Infection

Advanced Healthcare Materials, EarlyView.
This study explores nanoparticle delivery of the protein kinase C inhibitor bisindolylmaleimide‐I (BIM‐I) to combat influenza A virus infections. Encapsulation in biodegradable PLGA nanoparticles improved safety while maintaining the compound's strong antiviral activity.
Laura Klement, Jana Ismail, Josefine Schroeder, Amod Godbole, Johanna Schreiber, Christine Weber, Zoltan Cseresnyes, Marc T. Figge, Bettina Löffler, Ulrich S. Schubert, Stephanie Schubert, Christina Ehrhardt, Carsten Hoffmann   +12 more
wiley   +1 more source

High-level and high-throughput recombinant protein production by transient transfection of suspension-growing human 293-EBNA1 cells.

Nucleic Acids Research, 2002
Y. Durocher, S. Perret, A. Kamen
semanticscholar   +1 more source

Dual‐Functional Polyphosphoesters for Gene Delivery: Synergistic Effects of Guanidinium and Hydrophobic Side Chains in Degradable Polymers

Advanced Healthcare Materials, EarlyView.
This study presents guanidinium‐ and indole‐functionalized polyphosphoesters as degradable, non‐viral gene delivery vectors. Through precise tuning of charge density and hydrophobicity, these polymers form stable polyplexes with low toxicity. Remarkably, minor structural changes yield up to 200‐fold differences in transfection efficiency, highlighting ...
Markus Kötzsche, Andreas Dzierza, Jan Egger, Timo Rheinberger, Christin Weilandt, Frederik R. Wurm, Ivo Nischang, Dagmar Fischer, Kalina Peneva   +8 more
wiley   +1 more source

DNA-Loaded Nanoparticles Reprogram the Tumor Immune Microenvironment to Treat Brain Tumors. [PDF]

Small Sci
Yang J, Raj D, Slika H, Shahani A, Cheng L, Jain M, Idnani E, Luly KM, Ruchika F, Kraft C, Eberhart C, Brem H, Tyler B, Green JJ, Tzeng SY.   +14 more
europepmc   +1 more source

Transfection of neurotrophin‑3 into neural stem cells using ultrasound with microbubbles to treat denervated muscle atrophy

, 2017
Lin Gong, Changqing Jiang, Li Liu, Shengxiang Wan, Wen Tan, Sushuang Ma, Xiaojian Jia, Meiwei Wang, Azhen Hu, Yu Shi, Yu Zhang, Yuanyuan Shen, Feng Wang, Yun Chen   +13 more
openalex   +2 more sources