Results 51 to 60 of about 932,327 (388)

Clusterin, a haploinsufficient tumor suppressor gene in neuroblastomas [PDF]

, 2009
This article is available open access through the publisher’s website. Copyright @ 2009 The Authors.Background - Clusterin expression in various types of human cancers may be higher or lower than in normal tissue, and clusterin may promote or inhibit ...
Alessandro E. Caccamo, Andrei Thomas-Tikhonenko, Arturo Sala, Behrens, Bian, Brenner, Brignole, Brodeur, Caccamo, Caporali, Cervellera, Chi, Chung, Daisy Corvetta, Devauchelle, Dews, Farina, Giorgia Santilli, Goldman, Grund, Hackett, Hadaschik, He, Hellebrekers, Izabela Piotrowska, John, John Anderson, Julien, Klokov, Knoepfler, Leskov, Lonergan, Lourda, McLaughlin, Meister, Michael D. Hogarty, Michael Dews, Miyake, Miyake, Nakamura, Naugler, Neil J. Sebire, Nizard, Norris, Nourredine Himoudi, Nuutinen, Olesya Chayka, O’Donnell, O’Sullivan, Radisky, Redondo, Rhodes, Sambrook, Santilli, Saverio Bettuzzi, Scaltriti, Schmitz, Schulte, Shannan, Sian Gibson, Steinberg, Takase, Thomas-Tikhonenko, Trougakos, Urban, Ushmorov, Wanzel, Weiss, Winer, Wittke, Wolff, Xie, Zellweger, Zhang, Zhou   +74 more
core   +2 more sources

A DNA transfection system for generation of influenza A virus from eight plasmids.

Proceedings of the National Academy of Sciences of the United States of America, 2000
We have developed an eight-plasmid DNA transfection system for the rescue of infectious influenza A virus from cloned cDNA. In this plasmid-based expression system, viral cDNA is inserted between the RNA polymerase I (pol I) promoter and terminator ...
E. Hoffmann, G. Neumann, Y. Kawaoka, G. Hobom, R. Webster   +4 more
semanticscholar   +1 more source

Understanding In Vivo Fate of Nucleic Acid and Gene Medicines for the Rational Design of Drugs

Pharmaceutics, 2021
Nucleic acid and genetic medicines are increasingly being developed, owing to their potential to treat a variety of intractable diseases. A comprehensive understanding of the in vivo fate of these agents is vital for the rational design, discovery, and ...
Shintaro Fumoto, Tsuyoshi Yamamoto, Kazuya Okami, Yuina Maemura, Chisato Terada, Asako Yamayoshi, Koyo Nishida   +6 more
doaj   +1 more source

Haunted Bodies: Cell Switching, Getting Lost and Adaptive Geographies [PDF]

Avant, 2017
This article proposes the ideas of stochastic resonance and noise as devices with which to think of the body or self as plural and porous. Boundaries and surfaces are proposed as indefinite; cell switching and narratives of the self are discussed in ...
Jane Grant, Joanne “Bob” Whalley
doaj   +1 more source

Tetraethylenepentamine-Coated β Cyclodextrin Nanoparticles for Dual DNA and siRNA Delivery

Pharmaceutics, 2022
Nucleic acid reagents, including plasmid-encoded genes and small interfering RNA (siRNA), are promising tools for validating gene function and for the development of therapeutic agents.
Chi-Hsien Liu, Pei-Yin Shih, Cheng-Han Lin, Yi-Jun Chen, Wei-Chi Wu, Chun-Chao Wang   +5 more
doaj   +1 more source

Modeling genetic circuit behavior in transiently transfected mammalian cells [PDF]

, 2019
Binning cells by plasmid copy number is a common practice for analyzing transient transfection data. In many kinetic models of transfected cells, protein production rates are assumed to be proportional to plasmid copy number.
Belta, Calin, Isaacson, Samuel A., Wang, Junmin   +2 more
core   +2 more sources

Molecular Strings Significantly Improved the Gene Transfection Efficiency of Polycations.

Journal of the American Chemical Society, 2018
High transfection efficiency and low cytotoxicity are the two key factors to be considered in the design of gene carriers. Herein, a novel and versatile gene carrier (PLL-RT) was prepared by introducing "molecular string" RT (i.e., p-toluylsulfonyl ...
Huapan Fang, Zhaopei Guo, Lin Lin, Jie Chen, Pingjie Sun, Jiayan Wu, Caina Xu, Huayu Tian, Xuesi Chen   +8 more
semanticscholar   +1 more source

Gemini Cationic Lipid-Type Nanovectors Suitable for the Transfection of Therapeutic Plasmid DNA Encoding for Pro-Inflammatory Cytokine Interleukin-12

Pharmaceutics, 2021
Ample evidence exists on the role of interleukin-12 (IL-12) in the response against many pathogens, as well as on its remarkable antitumor properties. However, the unexpected toxicity and disappointing results in some clinical trials are prompting the ...
Natalia Sánchez-Arribas, María Martínez-Negro, Clara Aicart-Ramos, Conchita Tros de Ilarduya, Emilio Aicart, Andrés Guerrero-Martínez, Elena Junquera   +6 more
doaj   +1 more source

New amphiphilic amino acid derivatives for efficient DNA transfection in vitro [PDF]

, 2017
Nucleic acids-based therapies have recently developed as next-generationagents for treating and preventing viral infection, cancer, and genetic disorders,but their use is still limited due to its relatively poor delivery into targetedcells.
Antuña, Sebastián, Argarañá, María Fernanda, de Zan, María Mercedes, Giorello, Antonella, Muller, Diana, Peña, Lucía Carolina, Prieto, Claudio, Veaute, Carolina Melania Isabel   +7 more
core   +1 more source

The intracellular trafficking mechanism of Lipofectamine-based transfection reagents and its implication for gene delivery

Scientific Reports, 2016
Lipofectamine reagents are widely accepted as “gold-standard” for the safe delivery of exogenous DNA or RNA into cells. Despite this, a satisfactory mechanism-based explanation of their superior efficacy has remained mostly elusive thus far.
F. Cardarelli, L. Digiacomo, C. Marchini, A. Amici, Fabrizio Salomone, G. Fiume, Alessandro Rossetta, E. Gratton, D. Pozzi, G. Caracciolo   +9 more
semanticscholar   +1 more source