Association of Transfer RNA Fragments in White Blood Cells With Antibody Response to Bovine Leukemia Virus in Holstein Cattle [PDF]
Frontiers in Genetics, 2018 Bovine leukemia virus (BLV) affects cattle health and productivity worldwide, causing abnormal immune function and immunosuppression. Transfer RNA fragments (tRFs) are known to be involved in inhibition of gene expression and have been associated with ...
Tasia M. Taxis +4 more
doaj +5 more sources
Transfer RNA fragments replace microRNA regulators of the cholinergic poststroke immune blockade [PDF]
Proc Natl Acad Sci U S A, 2020 Significance Ischemic stroke triggers peripheral immunosuppression, increasing the susceptibility to poststroke pneumonia that is linked with poor survival.
Katarzyna Winek +14 more
semanticscholar +7 more sources
tatDB: a database of Ago1-mediated targets of transfer RNA fragments [PDF]
Nucleic Acids Res, 2022 tRNA-derived fragments (tRFs) are a class of emerging post-transcriptional regulators of gene expression likely binding to the transcripts of target genes. However, only a few tRFs targets have been experimentally validated, making it hard to extrapolate
Lingyu Guan, A. Grigoriev
semanticscholar +4 more sources
Targeting Fusobacterium nucleatum through chemical modifications of host-derived transfer RNA fragments [PDF]
ISME J, 2022 Host mucosal barriers possess an arsenal of defense molecules to maintain host-microbe homeostasis such as antimicrobial peptides and immunoglobulins.
Mengdi Yang +5 more
semanticscholar +4 more sources
Transfer RNA Fragments in the Kidney in Hypertension [PDF]
Hypertension, 2021 Supplemental Digital Content is available in the text. Small noncoding RNAs (sncRNAs) are important regulators of gene expression. In contrast with well-studied microRNAs, transfer RNA-derived RNA fragments (tRFs) are a new class of sncRNAs that has not ...
Xiaoqing Pan +8 more
semanticscholar +4 more sources
Characterization of Circulating Transfer RNA-Derived RNA Fragments in Cattle [PDF]
Frontiers in Genetics, 2015 The objective was to characterize naturally occurring circulating transfer RNA-derived RNA Fragments (tRFs) in cattle. Serum from eight clinically normal adult dairy cows was collected, and small non-coding RNAs were extracted immediately after ...
Eduardo eCasas +2 more
doaj +3 more sources
Transfer RNA-Derived Fragments, the Underappreciated Regulatory Small RNAs in Microbial Pathogenesis [PDF]
Frontiers in Microbiology, 2021 In eukaryotic organisms, transfer RNA (tRNA)-derived fragments have diverse biological functions. Considering the conserved sequences of tRNAs, it is not surprising that endogenous tRNA fragments in bacteria also play important regulatory roles.
Zhongyou Li, Bruce A. Stanton
doaj +3 more sources
Pre-symptomatic Parkinson’s disease blood test quantifying repetitive sequence motifs in transfer RNA fragments [PDF]
Nat AgingEarly, efficient Parkinson’s disease (PD) tests may facilitate pre-symptomatic diagnosis and disease-modifying therapies. Here we report elevated levels of PD-specific transfer RNA fragments carrying a conserved sequence motif (RGTTCRA-tRFs) in the ...
Nimrod Madrer +11 more
semanticscholar +4 more sources
Association of Circulating Transfer RNA fragments with antibody response to Mycoplasma bovis in beef cattle [PDF]
BMC Veterinary Research, 2018 Background High throughput sequencing allows identification of small non-coding RNAs. Transfer RNA Fragments are a class of small non-coding RNAs, and have been identified as being involved in inhibition of gene expression.
Eduardo Casas +5 more
doaj +3 more sources
tRFdb: a database for transfer RNA fragments [PDF]
Nucleic Acids Res, 2014 We have created tRFdb, the first database of transfer RNA fragments (tRFs), available at http://genome.bioch.virginia.edu/trfdb/. With over 100 small RNA libraries analyzed, the database currently contains the sequences and read counts of the three ...
Pankaj Kumar +3 more
semanticscholar +4 more sources