tatDB: a database of Ago1-mediated targets of transfer RNA fragments. [PDF]
Nucleic Acids Res, 2023 Abstract tRNA-derived fragments (tRFs) are a class of emerging post-transcriptional regulators of gene expression likely binding to the transcripts of target genes. However, only a few tRFs targets have been experimentally validated, making it hard to extrapolate the functions or binding mechanisms of tRFs.
Guan L, Grigoriev A.
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Transfer RNA fragments replace microRNA regulators of the cholinergic poststroke immune blockade. [PDF]
Proc Natl Acad Sci U S A, 2020 Significance Ischemic stroke triggers peripheral immunosuppression, increasing the susceptibility to poststroke pneumonia that is linked with poor survival. The poststroke brain initiates intensive communication with the immune system, and acetylcholine contributes to these messages; but the responsible molecules ...
Winek K +14 more
europepmc +11 more sources
Characterization of Circulating Transfer RNA-Derived RNA Fragments in Cattle [PDF]
Frontiers in Genetics, 2015 The objective was to characterize naturally occurring circulating transfer RNA-derived RNA Fragments (tRFs) in cattle. Serum from eight clinically normal adult dairy cows was collected, and small non-coding RNAs were extracted immediately after ...
Eduardo eCasas +2 more
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Transfer RNA-Derived Fragments, the Underappreciated Regulatory Small RNAs in Microbial Pathogenesis [PDF]
Frontiers in Microbiology, 2021 In eukaryotic organisms, transfer RNA (tRNA)-derived fragments have diverse biological functions. Considering the conserved sequences of tRNAs, it is not surprising that endogenous tRNA fragments in bacteria also play important regulatory roles.
Zhongyou Li, Bruce A. Stanton
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tRFdb: a database for transfer RNA fragments. [PDF]
Nucleic Acids Res, 2015 We have created tRFdb, the first database of transfer RNA fragments (tRFs), available at http://genome.bioch.virginia.edu/trfdb/. With over 100 small RNA libraries analyzed, the database currently contains the sequences and read counts of the three classes of tRFs for eight species: R. sphaeroides, S. pombe, D. melanogaster, C.
Kumar P, Mudunuri SB, Anaya J, Dutta A.
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Mechanisms of Transfer RNA Fragments Functionality Within and Between Cells and Organisms [PDF]
CellsTransfer RNA-derived fragments (tRFs) have become a significant category of small non-coding RNAs that likely play vital roles in various cellular functions.
Sathyanarayanan Vaidhyanathan +5 more
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Transfer RNA-derived fragments in aging Caenorhabditis elegans originate from abundant homologous gene copies [PDF]
Scientific Reports, 2021 Small RNAs that originate from transfer RNA (tRNA) species, tRNA-derived fragments (tRFs), play diverse biological functions but little is known for their association with aging.
GiWon Shin +5 more
doaj +7 more sources
Editorial: The genome’s rising star: Transfer RNA-derived small fragments [PDF]
Frontiers in Molecular Biosciences, 2022 Wei Yan
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Emerging roles of transfer RNA fragments in the CNS. [PDF]
BrainAbstract Transfer RNA-derived small RNAs (tsRNAs), previously considered inactive tRNA degradation products, have now been shown to be functional small non-coding RNAs. They may play important roles within the CNS and in brain-body interactions, both during normal developmental stages as well as in diverse brain pathologies.
Winek K, Soreq H.
europepmc +6 more sources
Transfer RNA-Derived Fragments and isomiRs Are Novel Components of Chronic TBI-Induced Neuropathology [PDF]
Biomedicines, 2022 Neuroinflammation is a secondary injury mechanism that evolves in the brain for months after traumatic brain injury (TBI). We hypothesized that an altered small non-coding RNA (sncRNA) signature plays a key role in modulating post-TBI secondary injury ...
Noora Puhakka +3 more
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