Mechanisms of Transfer RNA Fragments Functionality Within and Between Cells and Organisms [PDF]
CellsTransfer RNA-derived fragments (tRFs) have become a significant category of small non-coding RNAs that likely play vital roles in various cellular functions.
Sathyanarayanan Vaidhyanathan +5 more
doaj +5 more sources
Characterization of Circulating Transfer RNA-Derived RNA Fragments in Cattle [PDF]
Frontiers in Genetics, 2015 The objective was to characterize naturally occurring circulating transfer RNA-derived RNA Fragments (tRFs) in cattle. Serum from eight clinically normal adult dairy cows was collected, and small non-coding RNAs were extracted immediately after ...
Eduardo eCasas +2 more
doaj +4 more sources
Transfer RNA-Derived Fragments, the Underappreciated Regulatory Small RNAs in Microbial Pathogenesis [PDF]
Frontiers in Microbiology, 2021 In eukaryotic organisms, transfer RNA (tRNA)-derived fragments have diverse biological functions. Considering the conserved sequences of tRNAs, it is not surprising that endogenous tRNA fragments in bacteria also play important regulatory roles.
Zhongyou Li, Bruce A. Stanton
doaj +4 more sources
tatDB: a database of Ago1-mediated targets of transfer RNA fragments. [PDF]
Nucleic Acids Res, 2023 Abstract tRNA-derived fragments (tRFs) are a class of emerging post-transcriptional regulators of gene expression likely binding to the transcripts of target genes. However, only a few tRFs targets have been experimentally validated, making it hard to extrapolate the functions or binding mechanisms of tRFs.
Guan L, Grigoriev A.
europepmc +5 more sources
Transfer RNA fragments replace microRNA regulators of the cholinergic poststroke immune blockade. [PDF]
Proc Natl Acad Sci U S A, 2020 Significance Ischemic stroke triggers peripheral immunosuppression, increasing the susceptibility to poststroke pneumonia that is linked with poor survival. The poststroke brain initiates intensive communication with the immune system, and acetylcholine contributes to these messages; but the responsible molecules ...
Winek K +14 more
europepmc +11 more sources
Targeting Fusobacterium nucleatum through chemical modifications of host-derived transfer RNA fragments. [PDF]
ISME J, 2023 Abstract Host mucosal barriers possess an arsenal of defense molecules to maintain host-microbe homeostasis such as antimicrobial peptides and immunoglobulins. In addition to these well-established defense molecules, we recently reported small RNAs (sRNAs)-mediated interactions between human oral keratinocytes and Fusobacterium ...
Yang M +5 more
europepmc +5 more sources
Transfer RNA-derived fragments in aging Caenorhabditis elegans originate from abundant homologous gene copies [PDF]
Scientific Reports, 2021 Small RNAs that originate from transfer RNA (tRNA) species, tRNA-derived fragments (tRFs), play diverse biological functions but little is known for their association with aging.
GiWon Shin +5 more
doaj +6 more sources
Transfer RNA-Derived Fragments and isomiRs Are Novel Components of Chronic TBI-Induced Neuropathology [PDF]
Biomedicines, 2022 Neuroinflammation is a secondary injury mechanism that evolves in the brain for months after traumatic brain injury (TBI). We hypothesized that an altered small non-coding RNA (sncRNA) signature plays a key role in modulating post-TBI secondary injury ...
Noora Puhakka +3 more
doaj +5 more sources
Association of Transfer RNA Fragments in White Blood Cells With Antibody Response to Bovine Leukemia Virus in Holstein Cattle [PDF]
Frontiers in Genetics, 2018 Bovine leukemia virus (BLV) affects cattle health and productivity worldwide, causing abnormal immune function and immunosuppression. Transfer RNA fragments (tRFs) are known to be involved in inhibition of gene expression and have been associated with ...
Tasia M. Taxis +4 more
doaj +4 more sources
Association of Circulating Transfer RNA fragments with antibody response to Mycoplasma bovis in beef cattle [PDF]
BMC Veterinary Research, 2018 Background High throughput sequencing allows identification of small non-coding RNAs. Transfer RNA Fragments are a class of small non-coding RNAs, and have been identified as being involved in inhibition of gene expression.
Eduardo Casas +5 more
doaj +2 more sources