Transfer RNA-derived fragments in aging Caenorhabditis elegans originate from abundant homologous gene copies [PDF]
Scientific Reports, 2021 Small RNAs that originate from transfer RNA (tRNA) species, tRNA-derived fragments (tRFs), play diverse biological functions but little is known for their association with aging.
GiWon Shin +5 more
doaj +5 more sources
Transfer RNA-Derived Fragments and isomiRs Are Novel Components of Chronic TBI-Induced Neuropathology [PDF]
Biomedicines, 2022 Neuroinflammation is a secondary injury mechanism that evolves in the brain for months after traumatic brain injury (TBI). We hypothesized that an altered small non-coding RNA (sncRNA) signature plays a key role in modulating post-TBI secondary injury ...
Noora Puhakka +3 more
doaj +3 more sources
Synaptic vesicles contain small ribonucleic acids (sRNAs) including transfer RNA fragments (trfRNA) and microRNAs (miRNA) [PDF]
Sci Rep, 2015 Synaptic vesicles (SVs) are neuronal presynaptic organelles that load and release neurotransmitter at chemical synapses. In addition to classic neurotransmitters, we have found that synaptic vesicles isolated from the electric organ of Torpedo ...
Huinan Li +4 more
semanticscholar +4 more sources
Mechanisms of Transfer RNA Fragments Functionality Within and Between Cells and Organisms [PDF]
CellsTransfer RNA-derived fragments (tRFs) have become a significant category of small non-coding RNAs that likely play vital roles in various cellular functions.
Sathyanarayanan Vaidhyanathan +5 more
doaj +4 more sources
Emerging roles of transfer RNA fragments in the CNS [PDF]
BrainTransfer RNA-derived small RNAs (tsRNAs), previously considered inactive tRNA degradation products, have now been shown to be functional small non-coding RNAs.
Katarzyna Winek, H. Soreq
semanticscholar +4 more sources
Cerebrospinal fluid and blood profiles of transfer RNA fragments show age, sex and Parkinson’s disease-related changes [PDF]
bioRxiv, 2022 Transfer RNA fragments (tRFs) have recently been shown to be an important family of small regulatory RNAs with diverse functions. Recent reports have revealed modified tRF blood levels in a number of nervous system conditions including epilepsy, ischemic
Iddo Paldor +5 more
semanticscholar +4 more sources
Transfer RNA and ribosomal RNA fragments - emerging players in plant-microbe interactions. [PDF]
New Phytologist, 2023 According to current textbooks, the principal task of transfer and ribosomal RNAs (tRNAs and rRNAs, respectively) is synthesizing proteins. During the last decade, additional cellular roles for precisely processed tRNA and rRNAs fragments have become ...
R. Panstruga, Pietro D. Spanu
semanticscholar +2 more sources
Characteristics of Transfer RNA-Derived Fragments Expressed during Human Renal Cell Development: The Role of Dicer in tRF Biogenesis [PDF]
International Journal of Molecular Sciences, 2022 tRNA-derived fragments participate in the regulation of many processes, such as gene silencing, splicing and translation in many organisms, ranging from bacteria to humans.
Marek Kazimierczyk +7 more
semanticscholar +2 more sources
Small Non-coding Transfer RNA-Derived RNA Fragments (tRFs): Their Biogenesis, Function and Implication in Human Diseases [PDF]
Genomics & Informatics, 2015 tRNA-derived RNA fragments (tRFs) are an emerging class of non-coding RNAs (ncRNAs). A growing number of reports have shown that tRFs are not random degradation products but are functional ncRNAs made of specific tRNA cleavage. They play regulatory roles
Yu Fu +3 more
doaj +2 more sources
Horizontal transfer between loose compartments stabilizes replication of fragmented ribozymes.
PLoS Computational Biology, 2019 The emergence of replicases that can replicate themselves is a central issue in the origin of life. Recent experiments suggest that such replicases can be realized if an RNA polymerase ribozyme is divided into fragments short enough to be replicable by ...
Atsushi Kamimura +3 more
doaj +3 more sources