Results 11 to 20 of about 305,705 (319)
Association of Transfer RNA Fragments in White Blood Cells With Antibody Response to Bovine Leukemia Virus in Holstein Cattle [PDF]
Frontiers in Genetics, 2018 Bovine leukemia virus (BLV) affects cattle health and productivity worldwide, causing abnormal immune function and immunosuppression. Transfer RNA fragments (tRFs) are known to be involved in inhibition of gene expression and have been associated with ...
Tasia M. Taxis +4 more
doaj +4 more sources
Pre-symptomatic Parkinson's disease blood test quantifying repetitive sequence motifs in transfer RNA fragments. [PDF]
Nat AgingEarly, efficient Parkinson's disease (PD) tests may facilitate pre-symptomatic diagnosis and disease-modifying therapies. Here we report elevated levels of PD-specific transfer RNA fragments carrying a conserved sequence motif (RGTTCRA-tRFs) in the substantia nigra, cerebrospinal fluid and blood of patients with PD.
Madrer N +11 more
europepmc +5 more sources
Transfer RNA Fragments in the Kidney in Hypertension. [PDF]
Hypertension, 2021 Small noncoding RNAs (sncRNAs) are important regulators of gene expression. In contrast with well-studied microRNAs, transfer RNA-derived RNA fragments (tRFs) are a new class of sncRNAs that has not been studied in hypertension. This study aims to characterize renal tRFs and identify dysregulation and potential role of renal tRFs in ...
Pan X +8 more
europepmc +4 more sources
Transfer
New Phytologist, 2023 SummaryAccording to current textbooks, the principal task of transfer and ribosomal RNAs (tRNAs and rRNAs, respectively) is synthesizing proteins. During the last decade, additional cellular roles for precisely processed tRNA and rRNAs fragments have become evident in all kingdoms of life. These RNA fragments were originally overlooked in transcriptome
Ralph Panstruga, Pietro D. Spanu
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ASSOCIATION BETWEEN TRANSFER RNA-DERIVED FRAGMENTS AND VARICOCELE [PDF]
Fertility and Sterility, 2023 Öz bulunamadı.
Asli Metin Mahmutoglu +4 more
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tRFtarget: a database for transfer RNA-derived fragment targets [PDF]
Nucleic Acids Research, 2020 AbstractTransfer RNA-derived fragments (tRFs) are a new class of small non-coding RNAs and play important roles in biological and physiological processes. Prediction of tRF target genes and binding sites is crucial in understanding the biological functions of tRFs in the molecular mechanisms of human diseases.
Ningshan Li +3 more
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Transfer RNA‐derived fragments: origins, processing, and functions [PDF]
WIREs RNA, 2011 AbstractDeep sequencing approaches have revealed multiple types of small RNAs with known and unknown functions. In this review we focus on a recently identified group of small RNAs that are derived from transfer RNAs (tRNAs), tRNA fragments (tRFs). We review the mechanism of their processing and their functions in mammalian cells, and highlight points ...
Andrew, Sobala, Gyorgy, Hutvagner
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Targeting Fusobacterium nucleatum through chemical modifications of host-derived transfer RNA fragments. [PDF]
ISME J, 2023 Abstract Host mucosal barriers possess an arsenal of defense molecules to maintain host-microbe homeostasis such as antimicrobial peptides and immunoglobulins. In addition to these well-established defense molecules, we recently reported small RNAs (sRNAs)-mediated interactions between human oral keratinocytes and Fusobacterium ...
Yang M +5 more
europepmc +3 more sources
PtRFdb: a database for plant transfer RNA-derived fragments [PDF]
Database, 2018 Transfer RNA-derived fragments (tRFs) represent a novel class of small RNAs (sRNAs) generated through endonucleolytic cleavage of both mature and precursor transfer RNAs (tRNAs). These 14-28 nt length tRFs that have been extensively studied in animal kingdom are to be explored in plants. In this study, we introduce a database of plant tRFs named PtRFdb
Nikita Gupta +3 more
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Horizontal transfer between loose compartments stabilizes replication of fragmented ribozymes.
PLoS Computational Biology, 2019 The emergence of replicases that can replicate themselves is a central issue in the origin of life. Recent experiments suggest that such replicases can be realized if an RNA polymerase ribozyme is divided into fragments short enough to be replicable by ...
Atsushi Kamimura +3 more
doaj +3 more sources