Results 21 to 30 of about 155,620 (276)

The abundance of a transfer RNA-derived RNA fragment small RNA subpopulation is enriched in cauda spermatozoa [PDF]

ExRNA, 2020
AbstractThe small RNA (sRNA) landscape of mammalian spermatozoa is considerably altered as these gametic cells migrate through the segment specific microenvironments of the epididymis. More specifically, the microRNA (miRNA) species of sRNA dominates the sRNA landscape of spermatozoa of the proximal caput segment of the epididymis.
Simone J. Stanger, Ilana R. Bernstein, Amanda L. Anderson, Kate Hutcheon, Matthew D. Dun, Andrew L. Eamens, Brett Nixon   +6 more
openalex   +2 more sources

Plant transfer RNA‐derived fragments: Biogenesis and functions [PDF]

Journal of Integrative Plant Biology, 2021
AbstractProcessing of mature transfer RNAs (tRNAs) produces complex populations of tRNA‐derived fragments (tRFs). Emerging evidence shows that tRFs have important functions in bacteria, animals, and plants. Here, we review recent advances in understanding plant tRFs, focusing on their biological and cellular functions, such as regulating stress ...
Xuan Ma, Chunyan Liu, Xiaofeng Cao
openaire   +2 more sources

Synaptic vesicles contain small ribonucleic acids (sRNAs) including transfer RNA fragments (trfRNA) and microRNAs (miRNA). [PDF]

Sci Rep, 2015
Li H, Wu C, Aramayo R, Sachs MS, Harlow ML.   +4 more
europepmc   +3 more sources

Transfer RNA-derived fragments target and regulate ribosome-associated aminoacyl-transfer RNA synthetases

Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2018
Ribosome-associated noncoding (ranc) RNAs are a novel class of short regulatory RNAs with functions and origins that have not been well studied. In this present study, we functionally characterized the molecular activity of Saccharomyces cerevisiae transfer RNA (tRNA)-derived fragments (tRFs) during protein biosynthesis.
Anna Mleczko, Piotr Celichowski, Kamilla Bąkowska‐Żywicka   +2 more
openalex   +3 more sources

Biogenesis and Function of Transfer RNA-Related Fragments (tRFs) [PDF]

Trends in Biochemical Sciences, 2016
Noncoding small RNAs arise from the various un-annotated and annotated regions of the genome. When they arise from annotated genes, the noncoding small RNAs are functionally different from the parent genes. This is a brief review of one class of noncoding small RNAs, tRNA-related fragments (tRFs), which are generated from tRNA. tRFs have been suggested
Pankaj Kumar, Canan Kuscu, Anindya Dutta
openalex   +4 more sources

The Development of Methods for the Production of New Molecular Vaccines and Appropriate RNA Fragments to Counteract Unwanted Genes: A Pilot Study

Vaccines, 2023
The potential of viruses as appropriate vectors for the development of new therapeutic strategies, as well as for the design of molecular (DNA, RNA, and/or protein) vaccines via substitution of nucleotide sequences, has been proven.
Iskra Sainova, Vera Kolyovska, Iliana Ilieva, Tzvetanka Markova, Dimitrina Dimitrova-Dikanarova, Radka Hadjiolova   +5 more
doaj   +1 more source

Heat injury-induced tRNA fragment tRF-Ile-AAT-1 inhibits proliferation and invasion of bladder urothelial cancer cells

Di-san junyi daxue xuebao, 2021
Objective To investigate the effect of tRNA fragment differentially expressed between high and low malignant bladder urothelial carcinoma (BUC) cells induced by heat injury on the proliferation and invasion of BUC cells.
JIANG Li, ZHANG Junyong, TAN Peng, GOU Yang, HU Zhiya, LIN Yanjun, JIANG Qing   +6 more
doaj   +1 more source

Transfer RNA-derived Small RNAs: Degradation Fragments or Novel Regulatory Molecules?* [PDF]

PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS, 2011
Xin Chen, En‐Duo Wang
openalex   +2 more sources

Transfer RNA-derived fragment tRF-28-P4R8YP9LOND5 as a novel serum biomarker for gastric cancer: diagnostic efficacy and clinicopathological correlations. [PDF]

Transl Cancer Res
Gu F, Yuan Y, Cong H, Chen X, Wang W, Zhang J, Wu LP, Xuan SH.   +7 more
europepmc   +2 more sources

Transfer RNA‐derived fragments: origins, processing, and functions [PDF]

WIREs RNA, 2011
AbstractDeep sequencing approaches have revealed multiple types of small RNAs with known and unknown functions. In this review we focus on a recently identified group of small RNAs that are derived from transfer RNAs (tRNAs), tRNA fragments (tRFs). We review the mechanism of their processing and their functions in mammalian cells, and highlight points ...
Andrew, Sobala, Gyorgy, Hutvagner
openaire   +2 more sources