Results 21 to 30 of about 404,236 (314)

Differential Expression Profiles and Function Prediction of Transfer RNA-Derived Fragments in High-Grade Serous Ovarian Cancer [PDF]

BioMed Research International, 2021
Background The present study is aimed at providing systematic insight into the composition and expression of transfer RNA (tRNA) derivative transcription in high-grade serous ovarian cancer (HGSOC).
Buze Chen, Sicong Liu, Haihong Wang, Guilin Li, Xiaoyuan Lu, Hao Xu   +5 more
semanticscholar   +2 more sources

Clinical diagnostic values of transfer RNA-derived fragment tRF-19-3L7L73JD and its effects on the growth of gastric cancer cells [PDF]

Journal of Cancer, 2021
Background and aim: Medicine has made great progress, but gastric cancer is still one of the most common malignant tumors worldwide. tRNA-derived fragments (tRFs), a type of small non-coding RNA, have been found to play important roles in cancers. Due to
Yijing Shen, Yaoyao Xie, Xiuchong Yu, Shuangshuang Zhang, Qiu-Ting Wen, Guoliang Ye, Junming Guo   +6 more
semanticscholar   +2 more sources

Transfer RNA‐derived fragment 5′tRF‐Gly promotes the development of hepatocellular carcinoma by direct targeting of carcinoembryonic antigen‐related cell adhesion molecule 1

Cancer Science, 2022
Transfer RNA‐derived fragments are a group of small noncoding single‐stranded RNA that play essential roles in multiple diseases. However, their biological functions in carcinogenesis are not well understood.
Dekai Liu, Chengdong Wu, Jingjie Wang, Lufei Zhang, Zhongquan Sun, Shi-wei Chen, Yuan Ding, Weilin Wang   +7 more
semanticscholar   +2 more sources

Editorial: The genome’s rising star: Transfer RNA-derived small fragments [PDF]

Frontiers in Molecular Biosciences, 2022
Wei Yan
doaj   +2 more sources

PtRFdb: a database for plant transfer RNA-derived fragments [PDF]

Database J. Biol. Databases Curation, 2018
Transfer RNA-derived fragments (tRFs) represent a novel class of small RNAs (sRNAs) generated through endonucleolytic cleavage of both mature and precursor transfer RNAs (tRNAs).
N. Gupta, Ajeet Singh, Shafaque Zahra, Shailesh Kumar   +3 more
semanticscholar   +2 more sources

Expression analysis of transfer RNA-derived fragments in the blood of patients with moyamoya disease: A preliminary study

Molecular Medicine Reports, 2019
Moyamoya disease (MMD) is a rare chronic cerebrovascular disease mainly found in individuals of East Asian ethnicity, and its pathogenesis is largely unknown. Transfer RNA-derived fragments (tRFs) are novel biological entities involved in many biological
Chengjun Wang, Meng Zhao, Jia Wang, Dong Zhang, Shuo Wang, Ji-zong Zhao   +5 more
semanticscholar   +3 more sources

Serum transfer RNA‐derived fragment tRF‐31‐79MP9P9NH57SD acts as a novel diagnostic biomarker for non‐small cell lung cancer

Journal of clinical laboratory analysis (Print), 2022
tRNA‐derived fragments (tRFs) have been found to have a crucial function in the pathophysiology of cancers. However, the function of tRFs in non‐small cell lung cancer (NSCLC) is yet unknown.
Jipeng Li, C. Cao, Laifu Fang, Wanjun Yu
semanticscholar   +2 more sources

The Development of Methods for the Production of New Molecular Vaccines and Appropriate RNA Fragments to Counteract Unwanted Genes: A Pilot Study

Vaccines, 2023
The potential of viruses as appropriate vectors for the development of new therapeutic strategies, as well as for the design of molecular (DNA, RNA, and/or protein) vaccines via substitution of nucleotide sequences, has been proven.
Iskra Sainova, Vera Kolyovska, Iliana Ilieva, Tzvetanka Markova, Dimitrina Dimitrova-Dikanarova, Radka Hadjiolova   +5 more
doaj   +1 more source

Heat injury-induced tRNA fragment tRF-Ile-AAT-1 inhibits proliferation and invasion of bladder urothelial cancer cells

Di-san junyi daxue xuebao, 2021
Objective To investigate the effect of tRNA fragment differentially expressed between high and low malignant bladder urothelial carcinoma (BUC) cells induced by heat injury on the proliferation and invasion of BUC cells.
JIANG Li, ZHANG Junyong, TAN Peng, GOU Yang, HU Zhiya, LIN Yanjun, JIANG Qing   +6 more
doaj   +1 more source

Secretion of Mutant DNA and mRNA by the Exosomes of Breast Cancer Cells

Molecules, 2021
Exosomes are the small vesicles that are secreted by different types of normal and tumour cells and can incorporate and transfer their cargo to the recipient cells. The main goal of the present work was to study the tumour exosomes’ ability to accumulate
Olga E. Andreeva, Yuri Y. Shchegolev, Alexander M. Scherbakov, Ekaterina I. Mikhaevich, Danila V. Sorokin, Margarita V. Gudkova, Irina V. Bure, Ekaterina B. Kuznetsova, Dmitry S. Mikhaylenko, Marina V. Nemtsova, Dmitry V. Bagrov, Mikhail A. Krasil’nikov   +11 more
doaj   +1 more source