Results 31 to 40 of about 300 (142)

Transferosomes as a Novel Therapeutic Delivery System: A Review

Journal of Pharmaceutical Research International, 2021
The poor penetration rate of the skin as a natural barrier makes transdermal drug delivery problematic. To increase transdermal dispersion of bioactives, electrophoresis, iontophoresis, chemical permeation enhancers, microneedles, sonophoresis, and vesicular systems such as liposomes, niosomes, elastic liposomes such as ethosomes, and transferosomes ...
Umamaheswari D., Safeetha Shamsudheen, Najiya Nasri K. V., Kumar M., Vimal Mathew, Risvana Iqubal   +5 more
openaire   +2 more sources

Microglial Activation Under Hypoxic Conditions in Early Alzheimer's Disease: Can Natural SIRT1 Activators Be Therapeutic Allies in the Inflammation–Energy Axis?

Phytotherapy Research, Volume 40, Issue 6, Page 3354-3368, June 2026.
ABSTRACT Alzheimer's disease (AD) is a progressive neurodegenerative condition characterized by a preclinical stage that typically lasts for decades. Early on during this time, microglia react to pathological changes and become protective and even transiently delay neurodegeneration.
Sara Merlo, Cristiana Lucia Rita Lipari, Aurora Patti, Maria Angela Sortino   +3 more
wiley   +1 more source

FORMULATION DEVELOPMENT AND EVALUATION OF TRANSFEROSOMAL GEL

Journal of Drug Delivery and Therapeutics, 2018
Transfersomes are particularly optimized, ultradeformable (ultraflexible) lipid supramolecular aggregates, which are able to penetrate the mammalian skin intact. Transfersome is a type of carrier system which is capable of transdermal delivery of low as well as high molecular weight drugs.
Vivek Jain, Prabhat Jain, Neha Thakur
openaire   +2 more sources

Liposomes and transferosomes in the delivery of papain for the treatment of keloids and hypertrophic scars

PLOS ONE, 2023
Hypertrophic scars and keloids are characterized by an excessive collagen deposition. The available treatment options are invasive and can result in recurrence of scar formation. Using liposomes and transferosomes for the topical delivery of papain, a proteolytic enzyme, can be effective treatment.
Rachana Sapkota, Daniel J. Munt, Anthony E. Kincaid, Alekha K. Dash   +3 more
openaire   +3 more sources

Loratadine bioavailability via buccal transferosomal gel: formulation, statistical optimization, in vitro/in vivo characterization, and pharmacokinetics in human volunteers

Drug Delivery, 2017
Loratadine (LTD) is an antihistaminic drug that suffers limited solubility, poor oral bioavailability (owing to extensive first-pass metabolism), and highly variable oral absorption.
Mohammed H. Elkomy, Shahira F. El Menshawe, Heba A. Abou-Taleb, Marwa H. Elkarmalawy   +3 more
doaj   +1 more source

Transferosomes: A Novel Approach To Drug Delivery

, 2023
The development of innovative medicine delivery methods is currently generating renewed interest. These innovative drug delivery technologies also include vesicular drug delivery systems. The permeability of the skin, or TDDS, is extremely impermeable to macromolecules and hydrophilic medicines but permeable to small molecules and lipophilic ...
openaire   +1 more source

Nanotechnology in Skin Cancer Therapy: Recent Progress in Targeted Delivery

The Kaohsiung Journal of Medical Sciences, Volume 42, Issue 1, January 2026.
ABSTRACT Skin cancer, encompassing melanoma and non‐melanoma types, remains a significant public health concern globally. Conventional therapies—such as surgery, radiotherapy, chemotherapy, and immunotherapy—are constrained by poor skin penetration, systemic toxicity, and high recurrence rates.
Huang‐Ping Yu, Ching‐Yun Hsu, Jia‐You Fang, Zih‐Chan Lin   +3 more
wiley   +1 more source

Design and Characterization of a Transethosome‐Based Gel for Cutaneous Administration of Genistein

Journal of Nanotechnology, Volume 2026, Issue 1, 2026.
In this study, lipid nanovesicular systems such as ethosome and transethosome dispersions were studied as potential vehicles for the cutaneous administration of genistein, an isoflavone with antioxidant and chemopreventive properties. The lipophilicity of genistein requires specialized delivery systems suitable for transdermal administration. Genistein
Federico Santamaria, Ilenia Gugel, Valentyn Dzyhovskyi, Paolo Moretti, Paolo Mariani, Alessia Pepe, Maria Grazia Ortore, Michal Rawski, Anna Baldisserotto, Stefano Manfredini, Alice Casoni, Mascia Benedusi, Giuseppe Valacchi, Elisabetta Esposito, Ameeduzzafar Zafar   +14 more
wiley   +1 more source

Synthesis and Investigation of Apoptosis and Anti‐Metastatic Effects of Niosomes Containing the Extract of Colchicum kotschyi in MCF‐7

Natural Sciences, Volume 5, Issue 4, October 2025.
This graphical abstract shows the synthesis and biological effects of niosomes loaded with Colchicum kotschyi extract on MCF‐7 breast cancer cells. The extract was encapsulated via the thin‐film hydration method to form stable, spherical niosomes. The formulation enhanced cytotoxicity, induced apoptosis, and suppressed metastasis by increasing Bax and ...
Mahsa Kavousi, Maryam Kazemi Hatami
wiley   +1 more source

Deformable Pathways: Exploring Transferosome Architecture and Functionality in Modern Drug Delivery Systems

Journal of Bio-X Research
Transferosomes are ultradeformable nanocarrier vesicles designed to enhance transdermal drug delivery. Their unique elasticity enables them to traverse the stratum corneum by adapting to microscopic pores, facilitating the transport of both low- and high-
Shivlila Swami, Sameer Shafi, Pranita Waghmare, Ankita Gadhave, Madhuri Damane, Shoaeb Mohammad Syed   +5 more
doaj   +1 more source