The future of vesicular drug delivery: transferosomes in therapeutic advancement—applications, innovations and challenges [PDF]
BioMedical Engineering OnLineTransferosomes represent a novel vesicular drug delivery system developed to overcome the limitations of traditional transdermal systems. These ultra-deformable lipid bilayers facilitate barrier disruption via diffusion across the stratum corneum and ...
Chandrashekar Thalluri +2 more
exaly +3 more sources
Linoleic Acid-Based Transferosomes for Topical Ocular Delivery of Cyclosporine A [PDF]
Pharmaceutics, 2022 Delivering high-molecular-weight hydrophobic peptides, such as cyclosporine A, across the corneal epithelium remains a challenge that is complicated by other physio-anatomical ocular structures that limit the ocular bioavailability of such peptides ...
Lisa C Du Toit +2 more
exaly +4 more sources
Liposomes and transferosomes in the delivery of papain for the treatment of keloids and hypertrophic scars. [PDF]
PLoS ONE, 2023 Hypertrophic scars and keloids are characterized by an excessive collagen deposition. The available treatment options are invasive and can result in recurrence of scar formation.
Rachana Sapkota +3 more
doaj +2 more sources
Design, Characterization, and Wound-Healing Evaluation of Sodium Humate Transferosome-Loaded Alginate/HPMC Dermal Patches [PDF]
PharmaceuticsBackground/Objectives: For successful wound management, dressings must be maintained in a moist environment to optimally enhance the microenvironment of the wound and efficiently deliver bioactive agents.
Plamen Katsarov +9 more
doaj +2 more sources
Formulation, Optimization, and Evaluation of Transferosomes Co-Loaded with Methotrexate and Sorafenib for Anti-Arthritic Activity [PDF]
PharmaceuticsPurpose: This study was designed to develop a nanoparticle-based methotrexate (MTX) and sorafenib (SRF)-loaded transferosome (MTX-SRF-TFS) for effective management of arthritis through the transdermal route.
Muhammad Adnan +5 more
doaj +2 more sources
Curcumin Transferosome-Loaded Thermosensitive Intranasal in situ Gel as Prospective Antiviral Therapy for SARS-Cov-2 [PDF]
International Journal of Nanomedicine, 2023 Nermin E Eleraky,1 Mahmoud El-Badry,1 Mahmoud M Omar,2,3 Wesam M El-Koussi,4 Noha G Mohamed,5 Mohamed A Abdel-Lateef,6 Abeer S Hassan7 1Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt; 2Department of Pharmaceutics and ...
Eleraky NE +6 more
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Berberine HCl and diacerein loaded dual delivery transferosomes: Formulation and optimization using Box-Behnken design [PDF]
ADMET and DMPKIntroduction: Berberine is a poorly water-soluble alkaloid compound showing significant anti-inflammatory characteristics. It reduces the levels of pro-inflammatory and inflammatory cytokines, including tumour necrosis factor (TNF-????, IFN-????) and ...
Siddharth Singh, Rajendra Awasthi
doaj +2 more sources
Gouty Arthritis Treatment: Advancements in Topical Lipid-Based Nanocarrier Delivery Systems [PDF]
Advanced Pharmaceutical BulletinThe formation of urate crystals in the joints causes severe, erratic flare-ups of joint pain, swelling, and erythema in gout, one kind of inflammatory arthritis.
Shubham Kumar +4 more
doaj +2 more sources
Ultradeformable Vesicles for Wound Healing: Ethosomes, Transferosomes, and Transethosomes in Topical Drug Delivery [PDF]
PharmaceuticsWound healing is a dynamic and multifaceted biological process involving hemostasis, inflammation, proliferation, and tissue remodeling. Topical therapy is widely preferred for wound management due to its localized action and reduced systemic adverse ...
Shery Jacob +2 more
doaj +2 more sources
Nanomaterials, 2022 Transferosomes are one of the vesicular carriers that have received extensive research and attention recently because of their capacity to get beyond the barriers posed by the stratum corneum to penetration. The intent of the current study is to optimize
Hani Umme, Wan Hee Cheng, S Ramkanth
exaly +3 more sources