Results 51 to 60 of about 1,010,345 (279)

Nucleosomes affect local transformation efficiency [PDF]

, 2012
Genetic transformation is a natural process during which foreign DNA enters a cell and integrates into the genome. Apart from its relevance for horizontal gene transfer in nature, transformation is also the cornerstone of today's recombinant gene ...
Aslankoohi, Elham, Marchal, Kathleen, Sanchez-Rodriguez, Aminael, Sun, Hong, van der Zande, Elisa, Verstrepen, Kevin J, Voordeckers, Karin   +6 more
core   +2 more sources

RAD50 missense variants differentially affect the DNA damage response and mitotic progression

FEBS Letters, EarlyView.
RAD50 incorporates into the MRN complex and initiates the DNA damage response. Furthermore, RAD50 promotes mitotic progression. RAD50 missense variants capable of forming an MRN complex supported the DNA damage response and mitotic features to different extents in complementation experiments, indicating these functions are separable and might impact ...
Hanna Redeker, Swantje Kebel, Lea Völkening, Anna Vatselia, Louisa Weinhold, Girmay Asgedom, Axel Schambach, Detlev Schindler, Thilo Dörk, Kristine Bousset   +9 more
wiley   +1 more source

Highly efficient Agrobacterium rhizogenes-mediated hairy root transformation in citrus seeds and its application in gene functional analysis

Frontiers in Plant Science, 2023
Highly efficient genetic transformation technology is beneficial for plant gene functional research and molecular improvement breeding. However, the most commonly used Agrobacterium tumefaciens-mediated genetic transformation technology is time-consuming
Min Wang, Yang-Yang Qin, Nan-Nan Wei, Huan-Ying Xue, Wen-Shan Dai   +4 more
doaj   +1 more source

Landau Gauge Fixing supported by Genetic Algorithm [PDF]

, 1999
A class of algorithms for the Landau gauge fixing is proposed, which makes the steepest ascent (SA) method be more efficient by concepts of genetic algorithm.
Azusa Yamaguchi, Cucchieri, de Forcrand, Gribov, Hetrick, Hideo Nakajima, Mandula, Markham, Maskawa, Maskawa, Singer, Zwanziger, Zwanziger   +12 more
core   +2 more sources

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase in malaria parasites and enhances atovaquone efficacy

FEBS Letters, EarlyView.
Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer, Matheus Felipe Santos, Maurício Mazzine Filho, Gabriela Oliveira Castro, Agustín Hernández, Manoel Aparecido Peres, Alejandro Miguel Katzin, Marcell Crispim   +7 more
wiley   +1 more source

Recent Progress in the Regeneration and Genetic Transformation System of Cucumber

Applied Sciences, 2022
Cucumber (Cucumis sativus L.), belonging to the gourd family (Cucurbitaceae), is one of the major vegetable crops in China. Conventional genetic breeding methods are ineffective for improving the tolerance of cucumber to various environmental stresses ...
Jihong Tan, Lili Lin, Haiyan Luo, Shengjun Zhou, Yuqiang Zhu, Xin Wang, Li Miao, Huasen Wang, Peng Zhang   +8 more
doaj   +1 more source

Inhibition of oxidative metabolism leads to p53 genetic inactivation and transformation in neural stem cells [PDF]

, 2015
The final published version can be found here: http://dx.doi.org/10.1073/pnas ...
Anna Karlsson, Choksi, Deli A, Jayeta Saxena, Joanne Betts, Kiebish, Kim, L. Miguel Martins, Melania Capasso, Nick V. Henriquez, Paolo Salomoni, Pierluigi Nicotera, Sara Galavotti, Schwartzbaum, Sebastian Brandner, Stefano Bartesaghi, Valentina Minieri, Vincenzo De Laurenzi, Vincenzo Graziano   +18 more
core   +1 more source

Linked dimers of the AAA+ ATPase Msp1 reveal energetic demands and mechanistic plasticity for substrate extraction from lipid bilayers

FEBS Letters, EarlyView.
Cells must clear mislocalized or faulty proteins from membranes to survive. The AAA+ ATPase Msp1 performs this task, but dissecting how its six subunits work together is challenging. We engineered linked dimers with varied numbers of functional subunits to reveal how Msp1 subunits cooperate and use energy to extract proteins from the lipid bilayer ...
Deepika Gaur, Brian Acquaviva, Baylee A. Smith, Nathan Walker, Isabella Walter, Matthew L. Wohlever   +5 more
wiley   +1 more source

Leaf rust resistance in wheat and interpretation of the antifungal activity of silver and copper nanoparticles

Scientific Reports
Wheat production is jeopardized by Puccinia triticina, the pathogen responsible for wheat leaf rust. This study assessed the impact of silver (Ag) and copper (Cu) nanoparticles (NPs) on the control of wheat leaf rust disease and the underlying mechanisms
Atwa A. Atwa, Shreen S. Ahmed, Gehan H. Abd El-Aziz, Mohamed A. Abou-Zeid, Reda I. Omara, Nourhan A. Atwa, Ashraf H. Fahmy   +6 more
doaj   +1 more source