Results 51 to 60 of about 4,980,950 (333)
Approaches to genetic tool development for rapid domestication of non-model microorganisms
Biotechnology for Biofuels, 2021 Non-model microorganisms often possess complex phenotypes that could be important for the future of biofuel and chemical production. They have received significant interest the last several years, but advancement is still slow due to the lack of a robust
Lauren A. Riley, A. Guss
semanticscholar +1 more source
Recent Progress in the Regeneration and Genetic Transformation System of Cucumber
Applied Sciences, 2022 Cucumber (Cucumis sativus L.), belonging to the gourd family (Cucurbitaceae), is one of the major vegetable crops in China. Conventional genetic breeding methods are ineffective for improving the tolerance of cucumber to various environmental stresses ...
Jihong Tan +8 more
doaj +1 more source
FEBS Letters, EarlyView.In vivo IL‐10 produced by tissue‐resident tolDC is involved in maintaining/inducing tolerance. Depending on the agent used for ex vivo tolDC generation, cells acquire common features but prime T cells towards anergy, FOXP3+ Tregs, or Tr1 cells according to the levels of IL‐10 produced. Ex vivo‐induced tolDC were administered to patients to re‐establish/
Konstantina Morali +3 more
wiley +1 more source
FoxO1 signaling in B cell malignancies and its therapeutic targeting
FEBS Letters, EarlyView.FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac +3 more
wiley +1 more source
Proceedings of the National Academy of Sciences of the United States of America, 2015 Significance The paper describes an assay for cellular transformation that involves growth in low attachment (GILA). This assay is comparable to the gold-standard soft-agar assay, but it is much easier to perform and is suitable for high-throughput drug ...
Asaf Rotem +6 more
semanticscholar +1 more source
Average fold-change of genetic pathways in biological transitions [PDF]
arXiv, 2023 A biological transition from a state N to a state T is characterized by a rearrangement of the gene expression profile in the system, quantitatively measured through the differential expression of genes. In contrast, changes in genetic pathways are usually evaluated by means of hypothesis testing schemes. We introduce a quantitative measure in order to
arxiv
FEBS Letters, EarlyView.Metabolic dysfunction‐associated steatotic liver disease (MASLD) affects nearly one‐third of the global population and poses a significant risk of progression to cirrhosis or liver cancer. Here, we discuss the roles of hepatic dendritic cell subtypes in MASLD, highlighting their distinct contributions to disease initiation and progression, and their ...
Camilla Klaimi +3 more
wiley +1 more source
Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia
FEBS Letters, EarlyView.This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley +1 more source
The Beaker Phenomenon and the Genomic Transformation of Northwest Europe
Nature, 2018 From around 2750 to 2500 bc, Bell Beaker pottery became widespread across western and central Europe, before it disappeared between 2200 and 1800 bc. The forces that propelled its expansion are a matter of long-standing debate, and there is support for ...
Iňigo Olalde +143 more
semanticscholar +1 more source
Scientific ReportsWheat production is jeopardized by Puccinia triticina, the pathogen responsible for wheat leaf rust. This study assessed the impact of silver (Ag) and copper (Cu) nanoparticles (NPs) on the control of wheat leaf rust disease and the underlying mechanisms
Atwa A. Atwa +6 more
doaj +1 more source